Effect of early brain infarction after subarachnoid haemorrhage - A systematic review and meta-analysis.

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Effect of early brain infarction after subarachnoid haemorrhage - A systematic review and meta-analysis.

World Neurosurg. 2018 Apr 13;:

Authors: Gonçalves B, Turon R, Mendes A, Melo N, Lacerda P, Brasil P, Bozza FA, Kurtz P, Righy C

Abstract
OBJECTIVE: Aneurysmal subarachnoid haemorrhage (aSAH) is an acute cerebrovascular event that leads to devastating consequences. Early brain infarction (EBI) develops very early, within the first 72 hours after bleeding, but may have a significant impact on long-term outcomes. The incidence and impact of EBI in the prognosis of aSAH remain uncertain. We performed a systematic review and meta-analysis to evaluate the incidence of EBI in patients with aSAH and determine the effect of EBI on mortality and functional outcomes.
METHODS: We performed a systematic review and meta-analysis. Inclusion criteria were: Studies that performed a brain imaging study up to 72 hours of haemorrhage; both computed tomography (CT) or magnetic resonance imaging (MRI); and included a description of the findings of the brain imaging study (whether an infarct was present or not).
RESULTS: Ten studies that met the criteria were included. The incidence of EBI was 17%. The risk ratio (RR) for 3-month mortality was 2.18 (95% CI 1.48 - 3.30). The overall RR for poor outcome was 2.26 (95% CI 1.75 - 2.93).
CONCLUSIONS: EBI plays an important role in the outcome of patients with aSAH. Its significant impact could represent a new therapeutic frontier for improving outcomes of these patients.

PMID: 29660554 [PubMed - as supplied by publisher]

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