Nail involvement in patients with moderate to severe alopecia areata treated with oral tofacitinib.

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Nail involvement in patients with moderate to severe alopecia areata treated with oral tofacitinib.

J Dermatolog Treat. 2018 Apr 16;:1-18

Authors: Lee JS, Huh CH, Kwon O, Yoon HS, Cho S, Park HS

Abstract
BACKGROUND: A few anecdotal case reports demonstrated that tofacitinib improved nail changes associated with AA.
OBJECTIVE: To investigate nail changes in patients with AA treated with tofacitinib and evaluate the relationship between nail and hair responses to tofacitinib.
METHODS: This is a retrospective study of 33 adult patients with moderate-to-severe AA treated with oral tofacitinib monotherapy for at least 4 months.
RESULTS: Fifteen patients had nail involvement and demonstrated more severe hair loss than those without nail involvement (p = 0.040). However, there was no significant difference in hair regrowth between two groups. Of 15 patients with nail involvement, 11 (73.3%) showed improvement regardless of type of nail change; the first improvement was observed at a median of 5 months (range, 1-11) after administration. Nail improvement was associated with neither initial severity of hair loss nor hair response to tofacitinib. Nail improvement tended to occur later than hair regrowth.
CONCLUSIONS: Oral tofacitinib monotherapy improves nail involvement associated with AA. Nail involvement is not a poor prognosis factor in hair regrowth with tofacitinib treatment and there is no evident relationship between nail and hair responses.

PMID: 29658800 [PubMed - as supplied by publisher]

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