Pathogenetic Role of Endothelial Dysfunction in Idiopathic Vestibulopathy.

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Pathogenetic Role of Endothelial Dysfunction in Idiopathic Vestibulopathy.

Bull Exp Biol Med. 2018 Apr 16;:

Authors: Udut EV, Shchetinin PP, Rudenko TV, Lucieer F, Kingma H, Shchetinina AP, Pleshkov MO, Demkin VP, Udut VV

Abstract
Comparative analysis of the groups of patients with idiopathic bilateral vestibular hypofunction and a group of vestibulopathy patients with vertebrobasilar insufficiency demonstrated identity of the basic and additional diagnostic parameters in these syndromes as well as similarity in clinical diagnostic and anamnesis data. In all cases, functional assessment of endothelium-dependent vasodilation and selected biochemical marker sICAM-1 revealed endothelial dysfunction. Drug correction of endothelial dysfunction positively affected the manifestations of major and minor features of the syndrome, which confirmed the contribution of endothelial functional disturbances to the pathogenesis of bilateral vestibular hypofunction.

PMID: 29658088 [PubMed - as supplied by publisher]

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