Personalizing Breast Cancer Irradiation Using Biology: From Bench to the Accelerator.

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Personalizing Breast Cancer Irradiation Using Biology: From Bench to the Accelerator.

Front Oncol. 2018;8:83

Authors: Azria D, Brengues M, Gourgou S, Bourgier C

Abstract
While adjuvant treatments of early breast cancers (BCs) had significantly improved patients' overall survival, some of them will still develop locoregional relapses and/or severe late radio-induced toxicities. Here, we propose to review how to personalize locoregional treatment by identifying patients at high and low risk of locoregional relapse, patients at risk of late radio-induced side effects. We will, therefore, discuss how to enhance BC radiosensitivity. Finally, we will address how personalized radiotherapy could be implemented in prospective clinical trials.

PMID: 29675397 [PubMed]

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