[Transient hypogammaglobulinemia of infancy].

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[Transient hypogammaglobulinemia of infancy].

Rev Med Suisse. 2017 Apr 05;13(557):739-742

Authors: Bellutti Enders F, Conti F, Candotti F, Angelini F

Abstract
Transient hypogammaglobulinemia of infancy is characterized as a reduction of one or more classes of immunoglobulins with a response to vaccines and normal subpopulations of lymphocytes B presenting in the first years of life. The diagnosis is made a posteriori, once the levels of immunoglobulins are normalized, in general between 2 and 4 years of age. Clinical presentation varies : the child may be either asymptomatic or present with recurrent infections, atopy and / or auto-immunity. There are no clinical or immunological features that distinguish this condition from a common variable immunodeficiency (CVID). Because of the risk of severe infections, it is necessary a follow up by a paediatric immunologist. Depending on the presentation and evolution, a prophylaxis with antibiotics or a substitution with immunoglobulins might be indicated.

PMID: 28722362 [PubMed - indexed for MEDLINE]

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