Eupatilin inhibits adipogenesis through suppression of PPARγ activity in 3T3-L1 cells

Publication date: July 2018
Source:Biomedicine & Pharmacotherapy, Volume 103
Author(s): Jin Soo Kim, Seul Gi Lee, Kyoungjin Min, Taeg Kyu Kwon, Ha-Jeong Kim, Ju-Ock Nam
Eupatilin (5,7-dihydroxy-3′,4′,6-trimethoxyflavone) is a flavonoid compound from Artemisia species that possesses beneficial biological activities such as anti-cancer, anti-oxidation, and anti-inflammatory activities. However, an anti-adipogenic effect has not yet been reported. In this study, we found that eupatilin significantly inhibited the adipogenesis of 3T3-L1 adipocytes. Eupatilin decreased intracellular lipid accumulation and suppressed the expression level of key adipogenic regulators in 3T3-L1 adipocytes, including peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT-enhancer-binding protein alpha (C/EBPα), in a concentration-dependent manner. These results show that eupatilin significantly inhibits 3T3-L1 cell differentiation and suggest that it has potential as a novel anti-obesity therapy.

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