Psychopathological consequences of maltreatment among children and adolescents: A systematic review of the GxE literature

Publication date: Available online 20 June 2018
Source:Research in Developmental Disabilities
Author(s): Dario Maglione, Marcella Caputi, Benedetta Moretti, Simona Scaini
BackgroundIn the last years, several studies focused on the role of Gene-Environment interactions (GxE) in influencing psychopathological outcomes among maltreated children and adolescents. These studies analysed the effect of different genetic variations.AimsThe aim of the present review is to provide an overview of studies investigating GxE effects among maltreated children and adolescents.Methods and ProceduresA systematic literature review was performed by using the following keywords: "Child maltreatment" and "GxE", "Child maltreatment" and "Psychopathology", "Gene-Environment interaction", "Gene-environment correlation", "GxE and psychopathology", "Childhood trauma" and "Psychiatric symptoms", "Early adverse life events", "Early life stress", "Antisocial behaviour", "Depression", "Internalizing symptoms", through the following electronic databases: PubMed, Scopus and PsycINFO, from 2006 to 2017, finding a total of 31 papers.Outcomes and ResultsThe present review confirm that maltreatment produces worse psychopathological outcomes (antisocial behaviour, depression, and other psychiatric traits) in subjects with a specific genetic vulnerability.Conclusions and ImplicationsComprehending the pathways from child maltreatment to psychopathology in their full complexity will be essential to build efficacious preventive and therapeutic protocols.



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