Tired and Swollen: A Mono Mimic for Angioedema

Infectious mononucleosis (IM) secondary to Epstein-Barr virus (EBV) infection classically presents as a triad of cervical lymphadenopathy, fever and pharyngitis1 that is often accompanied by persistent fatigue. An uncommon presentation of early IM that has been reported rarely in the literature is periorbital edema. Here, we present a case of a 19 year-old female referred to allergy clinic for evaluation of angioedema. She was found to have periorbital swelling mistaken for angioedema and ultimately was diagnosed with IM despite lacking symptoms of the classic triad.

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