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Παρασκευή 6 Ιουλίου 2018

Effect of Sleep Deprivation on Hearing Levels in Rats

Publication date: Available online 6 July 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Jae Hyun Jung, Miryeong Kim, Seung Jae Lee, Eunsang Lee, Se A. Lee, Jong Dae Lee, Ji Ho Choi, Bo Gyung Kim

Abstract
Objectives

To our knowledge, the influence of sleep deprivation on hearing levels has yet to be assessed in animals. Therefore, we evaluated whether auditory function was affected by sleep deprivation in rats.

Methods

Male Wistar rats (aged 9 weeks, weighing 300-400 g) were used for the study and were randomly assigned to a control (n=15) or sleep deprivation group (n=12). Hearing levels were evaluated at baseline and 9 days after sleep deprivation using auditory evoked brainstem responses (ABRs) and distortion product otoacoustic emission (DPOAE) measurements. Blood was collected for the measurement of interleukin-1β and corticosterone levels.

Results

The ABR thresholds (at 8, 16, and 32 kHz) at 9 days were significantly elevated in the sleep deprivation group compared to the control group (p<0.05, respectively). The sleep deprivation group showed a defect in the function of outer hair cells, as evidenced by decreased levels of distortion product otoacoustic emission. IL-1β was significantly increased in the sleep deprivation group. Sleep-deprived rats exhibited rupture of Reissner's membrane and morphological damage to stereocilia.

Conclusion

These results suggest that sleep deprivation induces damage to the cochlea and results in hearing loss in Wistar rats.



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