A novel allergen-specific therapy with CD40-silenced B cells and dendritic cells

Publication date: Available online 23 August 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Motohiko Suzuki, Makoto Yokota, Yoshihisa Nakamura, Shinya Ozaki, Shingo Murakami

Summary

CD40-silenced B cells, induced by siRNA, inhibited allergic responses and symptoms antigen-specifically even after allergic rhinitis had been established. CD40-silenced B cells and CD40-silenced dendritic cells also have independent mechanisms with a synergic effect.

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