Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

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Σάββατο 18 Αυγούστου 2018

The association between periodontitis and interleukin-6 genetic polymorphism -174 G/C: A meta-analysis

Publication date: Available online 18 August 2018

Source: Archives of Oral Biology

Author(s): Bo Zhao, Ronghua Li

Abstract
Background

To evaluate the association between periodontitis and interleukin-6 (IL6) -174 G/C polymorphism by data synthesis and subgroup analysis.

Methods

Eighteen case-control studies from 16 articles with 1,616 cases and 1,511 controls were included in this meta-analysis by searching the public databases including PubMed, Embase and Web of Science databases by Jun 2018. Data syntheses were performed using Stata 9.0.

Results

There were inverse associations of IL6 -174 G/C polymorphism with both general periodontitis and overall periodontitis. In CC vs. GG inheritance model, whose effect was the most profound, the genetic polymorphism reduced the risks of general and overall periodontitis by 60% (95% CI = 0.25-0.65, P <  0.01) and 31% (95% CI = 0.38-0.97, P =  0.04) respectively. In addition, the G/C variation was likely to be protective against moderate (allele C vs. allele G: OR = 0.61, 95% CI = 0.43-0.87, P =  0.01; CC + GC vs. GG: OR = 0.57, 95% CI = 0.37-0.89, P =  0.01) and severe periodontitis (allele C vs. allele G: OR = 0.58, 95% CI = 0.41-0.84, P <  0.01; CC vs. GG: OR = 0.33, 95% CI = 0.13-0.82, P =  0.02) exclusively in Brazilian people. No reliable evidence was found regarding chronic periodontitis.

Conclusion

This meta-analysis suggests that IL6 -174 G/C polymorphism may be negatively associated with risk of periodontitis.



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