Central Obesity, Faster Maturation, and ‘PCOS’ in Girls

Publication date: Available online 5 October 2018

Source: Trends in Endocrinology & Metabolism

Author(s): Francis de Zegher, Abel López-Bermejo, Lourdes Ibáñez

Polycystic ovary syndrome (PCOS) development commonly starts with a mismatch between pre- and postnatal weight gain, leading to hepatovisceral fat excess. To escape from such central obesity, girls may accelerate their growth and/or maturation. This homeostatic mechanism is lost upon reaching adult height, and PCOS may ensue. Prevention and/or treatment of PCOS should aim at reducing central fat excess.

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