Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

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! # Ola via Alexandros G.Sfakianakis on Inoreader

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Τρίτη 13 Νοεμβρίου 2018

Early invasive Squamous Cell Carcinoma recurrence rates: a study examining surgical margins, tumor surface diameter, invasion depth and grade of differentiation in 1,296 cases over 9 years

Background

Invasive squamous cell carcinoma (SCC) is typically treated by surgical excision.

Method

Consecutive SCC excisions were reviewed prospectively in a single Australian center from 2009‐2017. Cases were examined for recurrence by histopathologic margins, microscopic tumor surface diameter, invasion depth, grade of differentiation and anatomic site.

Results

Over 9 years 1,296 cases were collected. By grade of differentiation maximum average microscopic surface diameters ranged from 8.0 to 9.6mm and maximum average depths from 1.3 to 2.5mm. Minimum average histopathologic margins for well, moderate and poorly differentiated SCC respectively were 1.4, 1.1 and 1.3mm. Recurrence occurred in 1.7 % of well (n=18/1084), 1.8 % moderate (n=3/165) and 6.4% in poorly differentiated (n=3/47) SCC. No recurrence occurred beyond a histopathologic margin of 3.5 mm for well and 2.5 mm for moderately differentiated SCC. Highest recurrence for well differentiated SCC by anatomic site were the lip (7.0%) then ear (4.6%).

Conclusion

We found a recurrence rate of 1.0% for histopathologic margins of 1.5 mm with early well differentiated SCC. The grade of differentiation and anatomic site had a larger influence on recurrence rates compared to the histopathologic margins. Poorly differentiated SCC and ear or lip sites require wider surgical margins.

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