Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
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Κρήτη 72100
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alsfakia@gmail.com

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Τρίτη 27 Νοεμβρίου 2018

Genetic and environmental influences on third molar root mineralization

Publication date: Available online 26 November 2018

Source: Archives of Oral Biology

Author(s): Giedrė Trakinienė, Irena Andriuškevičiūtė, Loreta Šalomskienė, Arūnas Vasiliauskas, Tomas Trakinis, Antanas Šidlauskas

Abstract
Objective

To assess the genetic and environmental influences on the variability of human third molar (M3) root mineralization stages via a twin study.

Design

The study sample consisted of 162 same-sex twins (66 dizygotic and 96 monozygotic, mean age: 17.9 years) with normal growth and development. Panoramic radiographs were evaluated to assess root mineralization stages of the upper and lower third molars, using the method of Demirijian et al. (1973). Zygosity was established using 15 specific DNA markers.

Results

Females developed their third molar roots earlier in life than males. Monozygotic twins (MZ) demonstrated higher intra-pair correlations for M3 root development stages than did DZ twins. An ACE model with additive genes, as well as common and specific environmental factors, provided the best explanation of variation in M3 root development. The mineralization of M3 roots showed highly additive genetic determination, varying from 60 to 63%, whereas a common environment contributed from 25 to 27%, and a specific environment only accounted 14% of the total variation, at most.

Conclusions

A considerable proportion of the total variability of the third molar root mineralization rate can be attributed to additive genetic effects, while common and specific environmental effects have a smaller, yet significant, impact.



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