Σφακιανάκης Αλέξανδρος
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Τρίτη 8 Ιανουαρίου 2019

Biomarkers of inflammatory external root resorption as a result of traumatic dental injury to permanent teeth in children

Publication date: Available online 7 January 2019

Source: Archives of Oral Biology

Author(s): Iwona Gregorczyk-Maga, Marek Kaszuba, Marta Olszewska, Sabina Lichołai, Teresa Iwaniec, Dorota Kościelniak, Wirginia Krzyściak, Anna Jurczak

Abstract
OBJECTIVE

External inflammatory root resorption (EIRR) is a common complication of traumatic dental injury (TDI) that can be detected radiologically. During EIRR, various proteins are released into gingival sulcus fluid (GCF). The aim of the study was to monitor the levels of selected proteins in GCF in children (8-16 years of age) in order to assess their utility in the early diagnosis of EIRR.

DESIGN

Twenty five children who experienced TDI to permanent incisors with ended root development were enrolled. GCF was collected from injured and control teeth with paper strips within seven days after TDI and on three visits during six-month follow-up. Concentrations of IL-1α, IL-1β, IL-6, IL-8, TNFα, RANKL and MMP-9 in GCF were measured using enzyme-linked immunosorbent assays. EIRR was confirmed by radiological imaging techniques.

RESULTS

Of all analyzed proteins, only the levels of IL-1α, Il-1β and TNFα in GCF from the injured teeth with resorption were higher than in GCF from control teeth on the visit during which the EIRR was diagnosed. In univariate logistic regression model, the concentration of IL-1α in GCF was found as the strongest risk factor for the occurrence of EIRR.

CONCLUSIONS

The composition of GCF may be indicative of EIRR after TDI. The monitoring of selected biomarkers in GCF may help to detect EIRR at its early stage and might be useful in reducing radiological exposure in children after TDI. IL-1α can be considered as a potential marker of the EIRR in children after TDI to the permanent teeth.



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