Fueling Ketone Metabolism Quenches Salt-Induced Hypertension

Publication date: Available online 19 January 2019

Source: Trends in Endocrinology & Metabolism

Author(s): David E. Place, Thirumala-Devi Kanneganti

Understanding the molecular mechanisms by which diet and exercise regulate disease has the potential to help identify new treatments. In their recent study, Chakraborty et al. (Cell Reports 2018;25:677–689) discovered that supplementation with a metabolic precursor produced β-hydroxybutyrate (BHB), counteracting the pathological effects of high-salt diet-induced hypertension, suggesting a new treatment modality.

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