TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions

Article

While yeast Rap1 regulates telomere length and protects telomeres from non-homologous end joining, its role in higher eukaryotes is controversial. Here the authors present evidence that in mammals, RAP1 cooperates with TRF2 to prevent homologous recombination-mediated repair of telomeres.

Nature Communications doi: 10.1038/ncomms10881

Authors: Rekha Rai, Yong Chen, Ming Lei, Sandy Chang

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