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Today, 23 Ιουνίου 2016, 5 hours ago
OtoRhinoLaryngology & Medicine,New Articles,June 23rd,2016
Journal of the American Academy of Child & Adolescent Psychiatry Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of the American Academy of Child & Adolescent Psychiatry *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downlo… περισσότερα » Journal of the American College of Cardiology Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of the American College of Cardiology Current Issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded … περισσότερα » Journal of Trauma and Acute Care Surgery Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of Trauma and Acute Care Surgery - Current Issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to … περισσότερα » Journal of Wound, Ostomy & Continence Nursing Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of Wound, Ostomy & Continence Nursing. Volume 43(3) May/June 2016 *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatical… περισσότερα » PLOS Pathogens Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* PLOS Pathogens: New Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be vi… περισσότερα » The Journal of Cell Biology Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* [image: Feed image] The Journal of Cell Biology current issue Untangling Topo IIs function at mitotic centromeres Δευτέρα, 20 Ιουνίου 2016, 4:00:36 μμ | Short, B.[image: Go to full article] Sister chromatids get tangled up during DNA replication and … περισσότερα » Topic-specific mini collections : Immunology (prepared for the 2016 AAI meeting) (HTML) (PDF) Cancer (prepared for the 2016 AACR meeting) 24th Annual Henry Kunkel Society Meeting Neuroscience (PDF) (HTML) Innate Immunity (PDF) Cancer (PDF) T Cells (PDF) Dendritic Cells and Macrophages (PDF) B Cell Immunity/HIV (PDF) Stem Cells and Cancer (PDF) Immunity and Cancer (PDF) Neurodegeneration (PDF) Viral Immunity Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *The Journal of Experimental Medicine* now prints topic-specific mini collections to showcase a handful of our recent publications. Click the links below to download a PDF version of our latest special issues. *Immunology (prepared for the 2016 AAI meeting) (HTML)* *(PDF)* *Cancer (prepared for the 2016 AACR meeting) * *24th Annual Henry Kunkel Society Meeting * *Neuroscience (PDF)* *(HTML)* *Innate Immunity (PDF)* *Cancer (PDF)* *T Cells (PDF)* *Dendritic Cells and Macrophages (PDF)* *B Cell Immunity/HIV (PDF)* *Stem Cells and Cancer (PDF)* *Immunity and Cancer (PDF)* *Neurodegenerat… περισσότερα » The Journal of Experimental Medicine Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be viewed in Inter… περισσότερα » Anti-Cancer Agents in Medicinal Chemistry Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Issue of Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Upda… περισσότερα » Climatic Change Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Climatic Change *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can… περισσότερα » Journal for General Philosophy of Science Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Journal for General Philosophy of Science *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded… περισσότερα » Mitigation and Adaptation Strategies for Global Change Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Mitigation and Adaptation Strategies for Global Change *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatical… περισσότερα » Medicine & Science in Sports & Exercise Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Medicine & Science in Sports & Exercise - Featured Articles - Featured Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is auto… περισσότερα » Nature Medicine Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Nature Medicine - Issue - nature.com science feeds *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your c… περισσότερα » NEJM Journal Watch: Physician's First Watch Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* NEJM Journal Watch: Physician's First Watch RSS Feed *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your… περισσότερα » New England Journal of Medicine Interviews Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* New England Journal of Medicine Interviews *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer … περισσότερα » Otology & Neurotology - Current Issue Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Otology & Neurotology - Current Issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and … περισσότερα » Pediatric Allergy, Immunology, and Pulmonology Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Pediatric Allergy, Immunology, and Pulmonology - Table of Contents *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically down… περισσότερα » Clinics in Plastic Surgery Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Clinics in Plastic Surgery *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to you… περισσότερα » British Journal of Cancer Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* British Journal of Cancer - AOP - nature.com science feeds *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded t… περισσότερα » Cancer News Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Cancer News – ScienceDaily *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be vie… περισσότερα » Case Reports in Oncology Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* CRO : Last 10 articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be viewed i… περισσότερα » Hellenic Anticancer Research Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Anticancer Research current issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can … περισσότερα » Paralleled comparison of vectors for the generation of CAR-T cells. Alexandros G. SfakianakisστοΘεραπείαΠριν από 22 δευτερόλεπτα T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches, several gene-transfer methods were used to deliver CARs or other genes into T-lymphocytes, equipping CAR-modified T cells with a property of recognizing and attacking antigen-expressing tumor cells in a major histocompatibility complex-independent manner. Here, we summarize the … περισσότερα » Minerals, Vol. 6, Pages 58: Mineralogical and Geochemical Characteristics of the Early Permian Upper No. 3 Coal from Southwestern Shandong, China Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The Upper No. 3 coal of the Early Permian age is a major workable seam in the southwestern Shandong coalfield, which is located in the eastern part of North China. From Early Jurassic to Neogene, the coalfield was subjected to intensive tectonic processes, leading to a significant rearrangement in depth of coal seams. In this paper, three Upper No. 3 coals occurring at −228, −670 and −938 m in the Luxi, Liangbaosi, and Tangkou mines, respectively, were collected to investigate their mineralogical and geochemical characteristics, with emphasis on modes of occurrence and origin of e… περισσότερα » Religions, Vol. 7, Pages 81: "Show Us Your God": Marilla Baker Ingalls and the Power of Religious Objects in Nineteenth-Century Burma Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This essay examines the unusual evangelical work of Marilla Baker Ingalls, an American Baptist missionary to Burma from 1851–1902. By the time of her death in Burma at the age of 75, Ingalls was known as one of the most successful Baptist evangelists among Burmese Buddhists. To understand the extraordinary dynamic of Ingalls' expanding Christian community, this essay focuses on two prominent objects at the Baptist mission: A life-sized dog statue that Ingalls kept chained at the edge of her property and a massive banyan tree covered with biblical illustrations and revered by locals… περισσότερα » Information, Vol. 7, Pages 36: Standard Compliant Hazard and Threat Analysis for the Automotive Domain Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The automotive industry has successfully collaborated to release the ISO 26262 standard for developing safe software for cars. The standard describes in detail how to conduct hazard analysis and risk assessments to determine the necessary safety measures for each feature. However, the standard does not concern threat analysis for malicious attackers or how to select appropriate security countermeasures. We propose the application of ISO 27001 for this purpose and show how it can be applied together with ISO 26262. We show how ISO 26262 documentation can be re-used and enhanced to … περισσότερα » Energies, Vol. 9, Pages 481: A Review of CO2-Enhanced Oil Recovery with a Simulated Sensitivity Analysis Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This paper reports on a comprehensive study of the CO2-EOR (Enhanced oil recovery) process, a detailed literature review and a numerical modelling study. According to past studies, CO2 injection can recover additional oil from reservoirs by reservoir pressure increment, oil swelling, the reduction of oil viscosity and density and the vaporization of oil hydrocarbons. Therefore, CO2-EOR can be used to enhance the two major oil recovery mechanisms in the field: miscible and immiscible oil recovery, which can be further increased by increasing the amount of CO2 injected, applying inn… περισσότερα » Religions, Vol. 7, Pages 80: Speculating the Subject of Money: Georg Simmel on Human Value Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This article initiates an inquiry into the sources and frameworks of value used to denote human subjects in modernity. In particular, I consider the conflation of monetary, legal, and theological registers employed to demarcate human worth. Drawing on Simmel's speculative genealogy of the money equivalent of human values, I consider the spectrum of ascriptions from specifically quantified to infinite human value. I suggest that predications of infinite human value require and imply quantified—and specifically monetary-economic—human value. Cost and worth, economically and legally … περισσότερα » Sensors, Vol. 16, Pages 947: Electronic Noses for Well-Being: Breath Analysis and Energy Expenditure Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The wealth of information concealed in a single human breath has been of interest for many years, promising not only disease detection, but also the monitoring of our general well-being. Recent developments in the fields of nano-sensor arrays and MEMS have enabled once bulky artificial olfactory sensor systems, or so-called "electronic noses", to become smaller, lower power and portable devices. At the same time, wearable health monitoring devices are now available, although reliable breath sensing equipment is somewhat missing from the market of physical, rather than chemical sens… περισσότερα » IJGI, Vol. 5, Pages 102: Exploring the Influence of Neighborhood Characteristics on Burglary Risks: A Bayesian Random Effects Modeling Approach Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα A Bayesian random effects modeling approach was used to examine the influence of neighborhood characteristics on burglary risks in Jianghan District, Wuhan, China. This random effects model is essentially spatial; a spatially structured random effects term and an unstructured random effects term are added to the traditional non-spatial Poisson regression model. Based on social disorganization and routine activity theories, five covariates extracted from the available data at the neighborhood level were used in the modeling. Three regression models were fitted and compared by the d… περισσότερα » Sensors, Vol. 16, Pages 950: The β-Lactamase Assay: Harnessing a FRET Biosensor to Analyse Viral Fusion Mechanisms Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The β-lactamase (BlaM) assay was first revealed in 1998 and was demonstrated to be a robust Förster resonance energy transfer (FRET)-based reporter system that was compatible with a range of commonly-used cell lines. Today, the BlaM assay is available commercially as a kit and can be utilised readily and inexpensively for an array of experimental procedures that require a fluorescence-based readout. One frequent application of the BlaM assay is the measurement of viral fusion—the moment at which the genetic material harboured within virus particles is released into the cytosol fol… περισσότερα » Sensors, Vol. 16, Pages 945: An Efficient Implementation of Fixed Failure-Rate Ratio Test for GNSS Ambiguity Resolution Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Ambiguity Resolution (AR) plays a vital role in precise GNSS positioning. Correctly-fixed integer ambiguities can significantly improve the positioning solution, while incorrectly-fixed integer ambiguities can bring large positioning errors and, therefore, should be avoided. The ratio test is an extensively used test to validate the fixed integer ambiguities. To choose proper critical values of the ratio test, the Fixed Failure-rate Ratio Test (FFRT) has been proposed, which generates critical values according to user-defined tolerable failure rates. This contribution provides eas… περισσότερα » Humanities, Vol. 5, Pages 48: Zombies and Refugees: Variations on the "Post-human" and the "Non-human" in Robin Campillo's Les Revenants (2004) and Fabrice Gobert's Les Revenants (2012–2015) Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This article examines the use of the zombie (or the "returned," the literal translation of the French term "revenant") in Fabrice Gobert's French series Les Revenants (2012–2015) as a narrative trope that evokes the recent wave of migration from Syria into Europe. In parallel, this article addresses Robin Campillo's 2004 original feature Les Revenants as it served as an inspiration for Gobert's work in 2012. Campillo's work, like Gobert's, is rooted in the treatment of refugees in France. Following the forceful closing of the Sangatte refugee camp in Calais in 2002, the Moroccan-b… περισσότερα » Toxins, Vol. 8, Pages 193: Tempo and Mode of the Evolution of Venom and Poison in Tetrapods Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Toxic weaponry in the form of venom and poison has evolved in most groups of animals, including all four major lineages of tetrapods. Moreover, the evolution of such traits has been linked to several key aspects of the biology of toxic animals including life-history and diversification. Despite this, attempts to investigate the macroevolutionary patterns underlying such weaponry are lacking. In this study we analyse patterns of venom and poison evolution across reptiles, amphibians, mammals, and birds using a suite of phylogenetic comparative methods. We find that each major linea… περισσότερα » Low-Dose Carotid Computed Tomography Angiography Using Pure Iterative Reconstruction. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: The aim of this study was to assess if a low-dose carotid computed tomography angiography (CTA) performed with pure iterative reconstruction (IR) is comparable to a conventional dose CTA protocol. Methods: Twenty patients were included. Radiation dose was divided into a low-dose acquisition reconstructed with pure IR and a conventional dose acquisition reconstructed with 40% hybrid IR. Dose, image noise, contrast resolution, spatial resolution, and carotid artery stenosis were measured. Results: Mean effective dose was significantly lower for low-dose than conventional do… περισσότερα » Computed Tomography Imaging of a Hip Prosthesis Using Iterative Model-Based Reconstruction and Orthopaedic Metal Artefact Reduction: A Quantitative Analysis. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objectives: To quantify the combined use of iterative model-based reconstruction (IMR) and orthopaedic metal artefact reduction (O-MAR) in reducing metal artefacts and improving image quality in a total hip arthroplasty phantom. Methods: Scans acquired at several dose levels and kVps were reconstructed with filtered back-projection (FBP), iterative reconstruction (iDose4) and IMR, with and without O-MAR. Computed tomography (CT) numbers, noise levels, signal-to-noise-ratios and contrast-to-noise-ratios were analysed. Results: Iterative model-based reconstruction results in overall i… περισσότερα » Regional Lung Ventilation Analysis Using Temporally Resolved Magnetic Resonance Imaging. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: We propose a computer-aided method for regional ventilation analysis and observation of lung diseases in temporally resolved magnetic resonance imaging (4D MRI). Methods: A shape model-based segmentation and registration workflow was used to create an atlas-derived reference system in which regional tissue motion can be quantified and multimodal image data can be compared regionally. Model-based temporal registration of the lung surfaces in 4D MRI data was compared with the registration of 4D computed tomography (CT) images. A ventilation analysis was performed on 4D MR i… περισσότερα » Active Surveillance of Small Renal Masses: A Review on the Role of Imaging With a Focus on Growth Rate. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: This study aimed to systematically summarize the current literature in the field of active surveillance for small renal masses, with the primary focus being the role of imaging in the primary decision-making and subsequent follow-up. Materials: A systematic review of the electronic databases PubMed and Web of Knowledge was performed according to Preferred Reporting Items for Systematic Reviews and Meta-analysis statement guidelines. Variables were extracted from the data set and included the following: (1) patient demographics, (2) tumor characteristics, and (3) study des… περισσότερα » Renal Cell Carcinoma: Accuracy of Multidetector Computed Tomography in the Assessment of Renal Sinus Fat Invasion. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Purpose: The purpose of this study was to evaluate the accuracy of multidetector computed tomography (MDCT) in the preoperative assessment of renal sinus fat invasion (RSFI) in patients with renal cell carcinoma (RCC) and to assess imaging features that improve detection of RSFI on CT. Methods: This is a single-institution retrospective review of 53 consecutive patients with histologically proven RCC who underwent triple-phase preoperative contrast MDCT prior to partial or radical nephrectomy. Two experienced radiologists (R1 and R2), blinded to the final histology result, independe… περισσότερα » Cystic Cervicitis: A Case Report and Literature Review of Cystic Cervical Lesions. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα We present a case of a 30-year-old woman who, while undergoing infertility evaluation, was found to have a large cystic cervical mass, shown to be cystic cervicitis on cervical cone biopsy. Differential diagnosis for benign cystic cervical lesions includes Nabothian cysts, tunnel cluster, endocervical hyperplasia, and cervicitis, whereas cystic cervical malignancies include adenocarcinoma and adenoma malignum. While it is crucial to differentiate benign from malignant lesions, imaging characteristics often overlap and may not provide a specific diagnosis. In difficult cases, definit… περισσότερα » Contrast-Enhanced Dixon Fat-Water Separation Imaging of the Spine: Added Value of Fat, In-Phase and Opposed-Phase Imaging in Marrow Lesion Detection. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: Beyond fat suppression (FS), the efficacy of (fat-water separation or Dixon [FWD]) Dixon imaging in gadolinium-enhanced spine imaging has yet to be validated. This study evaluated enhanced opposed-phase (OP) and fat-only (FO) images along with water-only (WO; FS) images against traditional unenhanced techniques and rated the incremental value of in-phase imaging in patients with presumed neoplastic focal spine lesions. Methods: A retrospective cohort study of 36 subjects with focal spine lesions imaged with FWD was evaluated qualitatively and quantitatively. Results: Enha… περισσότερα » Comparison of Knowledge-based Iterative Model Reconstruction and Hybrid Reconstruction Techniques for Liver CT Evaluation of Hypervascular Hepatocellular Carcinoma. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: The purpose of this work was to evaluate the image quality, lesion conspicuity, and dose reduction provided by knowledge-based iterative model reconstruction (IMR) in computed tomography (CT) of the liver compared with hybrid iterative reconstruction (IR) and filtered back projection (FBP) in patients with hepatocellular carcinoma (HCC). Methods: Fifty-six patients with 61 HCCs who underwent multiphasic reduced-dose CT (RDCT; n = 33) or standard-dose CT (SDCT; n = 28) were retrospectively evaluated. Reconstructed images with FBP, hybrid IR (iDose4), IMR were evaluated for… περισσότερα » Periprosthetic Artifact Reduction Using Virtual Monochromatic Imaging Derived From Gemstone Dual-Energy Computed Tomography and Dedicated Software. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: The aim of this study was to explore the usefulness of combined virtual monochromatic imaging and metal artifact reduction software (MARS) for the evaluation of musculoskeletal periprosthetic tissue. Methods: Measurements were performed in periprosthetic and remote regions in 80 patients using a high-definition scanner. Polychromatic images with and without MARS and virtual monochromatic images were obtained. Results: Periprosthetic polychromatic imaging (PI) showed significant differences compared with remote areas among the 3 tissues explored (P from #Medicine via ola K… περισσότερα » Volumetric Single-Beat Coronary Computed Tomography Angiography: Relationship of Image Quality, Heart Rate, and Body Mass Index. Initial Patient Experience With a New Computed Tomography Scanner. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Background: Cardiac computed tomography (CT) image quality (IQ) is very important for accurate diagnosis. We propose to evaluate IQ expressed as Likert scale, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) from coronary CT angiography images acquired with a new volumetric single-beat CT scanner on consecutive patients and assess the IQ dependence on heart rate (HR) and body mass index (BMI). Methods: We retrospectively analyzed the data of the first 439 consecutive patients (mean age, 55.13 [SD, 12.1] years; 51.47% male), who underwent noninvasive coronary CT angiogr… περισσότερα » Cell Host & Microbe Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 31 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Cell Host & Microbe *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your compu… περισσότερα » Current Opinion in Immunology Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 31 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Current Opinion in Immunology *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to … περισσότερα » Cell Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Cell via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can … περισσότερα » Cell Reports Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Cell Reports *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and… περισσότερα » Cell Metabolism Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Cell Metabolism *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer … περισσότερα » Behavioral and Psychological Symptoms and Caregiver Burden in Mexican Alzheimer's Disease Patients sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
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OtoRhinoLaryngology & Medicine,New Articles,June 23rd,2016
Journal of the American Academy of Child & Adolescent Psychiatry Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of the American Academy of Child & Adolescent Psychiatry *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downlo… περισσότερα » Journal of the American College of Cardiology Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of the American College of Cardiology Current Issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded … περισσότερα » Journal of Trauma and Acute Care Surgery Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of Trauma and Acute Care Surgery - Current Issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to … περισσότερα » Journal of Wound, Ostomy & Continence Nursing Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of Wound, Ostomy & Continence Nursing. Volume 43(3) May/June 2016 *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatical… περισσότερα » PLOS Pathogens Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* PLOS Pathogens: New Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be vi… περισσότερα » The Journal of Cell Biology Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* [image: Feed image] The Journal of Cell Biology current issue Untangling Topo IIs function at mitotic centromeres Δευτέρα, 20 Ιουνίου 2016, 4:00:36 μμ | Short, B.[image: Go to full article] Sister chromatids get tangled up during DNA replication and … περισσότερα » Topic-specific mini collections : Immunology (prepared for the 2016 AAI meeting) (HTML) (PDF) Cancer (prepared for the 2016 AACR meeting) 24th Annual Henry Kunkel Society Meeting Neuroscience (PDF) (HTML) Innate Immunity (PDF) Cancer (PDF) T Cells (PDF) Dendritic Cells and Macrophages (PDF) B Cell Immunity/HIV (PDF) Stem Cells and Cancer (PDF) Immunity and Cancer (PDF) Neurodegeneration (PDF) Viral Immunity Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *The Journal of Experimental Medicine* now prints topic-specific mini collections to showcase a handful of our recent publications. Click the links below to download a PDF version of our latest special issues. *Immunology (prepared for the 2016 AAI meeting) (HTML)* *(PDF)* *Cancer (prepared for the 2016 AACR meeting) * *24th Annual Henry Kunkel Society Meeting * *Neuroscience (PDF)* *(HTML)* *Innate Immunity (PDF)* *Cancer (PDF)* *T Cells (PDF)* *Dendritic Cells and Macrophages (PDF)* *B Cell Immunity/HIV (PDF)* *Stem Cells and Cancer (PDF)* *Immunity and Cancer (PDF)* *Neurodegenerat… περισσότερα » The Journal of Experimental Medicine Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be viewed in Inter… περισσότερα » Anti-Cancer Agents in Medicinal Chemistry Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Issue of Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Upda… περισσότερα » Climatic Change Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Climatic Change *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can… περισσότερα » Journal for General Philosophy of Science Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Journal for General Philosophy of Science *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded… περισσότερα » Mitigation and Adaptation Strategies for Global Change Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results for Mitigation and Adaptation Strategies for Global Change *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatical… περισσότερα » Medicine & Science in Sports & Exercise Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Medicine & Science in Sports & Exercise - Featured Articles - Featured Articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is auto… περισσότερα » Nature Medicine Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Nature Medicine - Issue - nature.com science feeds *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your c… περισσότερα » NEJM Journal Watch: Physician's First Watch Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* NEJM Journal Watch: Physician's First Watch RSS Feed *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your… περισσότερα » New England Journal of Medicine Interviews Alexandros G. SfakianakisστοΙατρικά Άρθρα by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* New England Journal of Medicine Interviews *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer … περισσότερα » Otology & Neurotology - Current Issue Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Otology & Neurotology - Current Issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and … περισσότερα » Pediatric Allergy, Immunology, and Pulmonology Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Pediatric Allergy, Immunology, and Pulmonology - Table of Contents *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically down… περισσότερα » Clinics in Plastic Surgery Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Clinics in Plastic Surgery *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to you… περισσότερα » British Journal of Cancer Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* British Journal of Cancer - AOP - nature.com science feeds *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded t… περισσότερα » Cancer News Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Cancer News – ScienceDaily *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be vie… περισσότερα » Case Reports in Oncology Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* CRO : Last 10 articles *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be viewed i… περισσότερα » Hellenic Anticancer Research Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Anticancer Research current issue *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can … περισσότερα » Paralleled comparison of vectors for the generation of CAR-T cells. Alexandros G. SfakianakisστοΘεραπείαΠριν από 22 δευτερόλεπτα T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches, several gene-transfer methods were used to deliver CARs or other genes into T-lymphocytes, equipping CAR-modified T cells with a property of recognizing and attacking antigen-expressing tumor cells in a major histocompatibility complex-independent manner. Here, we summarize the … περισσότερα » Minerals, Vol. 6, Pages 58: Mineralogical and Geochemical Characteristics of the Early Permian Upper No. 3 Coal from Southwestern Shandong, China Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The Upper No. 3 coal of the Early Permian age is a major workable seam in the southwestern Shandong coalfield, which is located in the eastern part of North China. From Early Jurassic to Neogene, the coalfield was subjected to intensive tectonic processes, leading to a significant rearrangement in depth of coal seams. In this paper, three Upper No. 3 coals occurring at −228, −670 and −938 m in the Luxi, Liangbaosi, and Tangkou mines, respectively, were collected to investigate their mineralogical and geochemical characteristics, with emphasis on modes of occurrence and origin of e… περισσότερα » Religions, Vol. 7, Pages 81: "Show Us Your God": Marilla Baker Ingalls and the Power of Religious Objects in Nineteenth-Century Burma Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This essay examines the unusual evangelical work of Marilla Baker Ingalls, an American Baptist missionary to Burma from 1851–1902. By the time of her death in Burma at the age of 75, Ingalls was known as one of the most successful Baptist evangelists among Burmese Buddhists. To understand the extraordinary dynamic of Ingalls' expanding Christian community, this essay focuses on two prominent objects at the Baptist mission: A life-sized dog statue that Ingalls kept chained at the edge of her property and a massive banyan tree covered with biblical illustrations and revered by locals… περισσότερα » Information, Vol. 7, Pages 36: Standard Compliant Hazard and Threat Analysis for the Automotive Domain Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The automotive industry has successfully collaborated to release the ISO 26262 standard for developing safe software for cars. The standard describes in detail how to conduct hazard analysis and risk assessments to determine the necessary safety measures for each feature. However, the standard does not concern threat analysis for malicious attackers or how to select appropriate security countermeasures. We propose the application of ISO 27001 for this purpose and show how it can be applied together with ISO 26262. We show how ISO 26262 documentation can be re-used and enhanced to … περισσότερα » Energies, Vol. 9, Pages 481: A Review of CO2-Enhanced Oil Recovery with a Simulated Sensitivity Analysis Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This paper reports on a comprehensive study of the CO2-EOR (Enhanced oil recovery) process, a detailed literature review and a numerical modelling study. According to past studies, CO2 injection can recover additional oil from reservoirs by reservoir pressure increment, oil swelling, the reduction of oil viscosity and density and the vaporization of oil hydrocarbons. Therefore, CO2-EOR can be used to enhance the two major oil recovery mechanisms in the field: miscible and immiscible oil recovery, which can be further increased by increasing the amount of CO2 injected, applying inn… περισσότερα » Religions, Vol. 7, Pages 80: Speculating the Subject of Money: Georg Simmel on Human Value Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This article initiates an inquiry into the sources and frameworks of value used to denote human subjects in modernity. In particular, I consider the conflation of monetary, legal, and theological registers employed to demarcate human worth. Drawing on Simmel's speculative genealogy of the money equivalent of human values, I consider the spectrum of ascriptions from specifically quantified to infinite human value. I suggest that predications of infinite human value require and imply quantified—and specifically monetary-economic—human value. Cost and worth, economically and legally … περισσότερα » Sensors, Vol. 16, Pages 947: Electronic Noses for Well-Being: Breath Analysis and Energy Expenditure Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The wealth of information concealed in a single human breath has been of interest for many years, promising not only disease detection, but also the monitoring of our general well-being. Recent developments in the fields of nano-sensor arrays and MEMS have enabled once bulky artificial olfactory sensor systems, or so-called "electronic noses", to become smaller, lower power and portable devices. At the same time, wearable health monitoring devices are now available, although reliable breath sensing equipment is somewhat missing from the market of physical, rather than chemical sens… περισσότερα » IJGI, Vol. 5, Pages 102: Exploring the Influence of Neighborhood Characteristics on Burglary Risks: A Bayesian Random Effects Modeling Approach Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα A Bayesian random effects modeling approach was used to examine the influence of neighborhood characteristics on burglary risks in Jianghan District, Wuhan, China. This random effects model is essentially spatial; a spatially structured random effects term and an unstructured random effects term are added to the traditional non-spatial Poisson regression model. Based on social disorganization and routine activity theories, five covariates extracted from the available data at the neighborhood level were used in the modeling. Three regression models were fitted and compared by the d… περισσότερα » Sensors, Vol. 16, Pages 950: The β-Lactamase Assay: Harnessing a FRET Biosensor to Analyse Viral Fusion Mechanisms Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The β-lactamase (BlaM) assay was first revealed in 1998 and was demonstrated to be a robust Förster resonance energy transfer (FRET)-based reporter system that was compatible with a range of commonly-used cell lines. Today, the BlaM assay is available commercially as a kit and can be utilised readily and inexpensively for an array of experimental procedures that require a fluorescence-based readout. One frequent application of the BlaM assay is the measurement of viral fusion—the moment at which the genetic material harboured within virus particles is released into the cytosol fol… περισσότερα » Sensors, Vol. 16, Pages 945: An Efficient Implementation of Fixed Failure-Rate Ratio Test for GNSS Ambiguity Resolution Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Ambiguity Resolution (AR) plays a vital role in precise GNSS positioning. Correctly-fixed integer ambiguities can significantly improve the positioning solution, while incorrectly-fixed integer ambiguities can bring large positioning errors and, therefore, should be avoided. The ratio test is an extensively used test to validate the fixed integer ambiguities. To choose proper critical values of the ratio test, the Fixed Failure-rate Ratio Test (FFRT) has been proposed, which generates critical values according to user-defined tolerable failure rates. This contribution provides eas… περισσότερα » Humanities, Vol. 5, Pages 48: Zombies and Refugees: Variations on the "Post-human" and the "Non-human" in Robin Campillo's Les Revenants (2004) and Fabrice Gobert's Les Revenants (2012–2015) Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This article examines the use of the zombie (or the "returned," the literal translation of the French term "revenant") in Fabrice Gobert's French series Les Revenants (2012–2015) as a narrative trope that evokes the recent wave of migration from Syria into Europe. In parallel, this article addresses Robin Campillo's 2004 original feature Les Revenants as it served as an inspiration for Gobert's work in 2012. Campillo's work, like Gobert's, is rooted in the treatment of refugees in France. Following the forceful closing of the Sangatte refugee camp in Calais in 2002, the Moroccan-b… περισσότερα » Toxins, Vol. 8, Pages 193: Tempo and Mode of the Evolution of Venom and Poison in Tetrapods Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Toxic weaponry in the form of venom and poison has evolved in most groups of animals, including all four major lineages of tetrapods. Moreover, the evolution of such traits has been linked to several key aspects of the biology of toxic animals including life-history and diversification. Despite this, attempts to investigate the macroevolutionary patterns underlying such weaponry are lacking. In this study we analyse patterns of venom and poison evolution across reptiles, amphibians, mammals, and birds using a suite of phylogenetic comparative methods. We find that each major linea… περισσότερα » Low-Dose Carotid Computed Tomography Angiography Using Pure Iterative Reconstruction. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: The aim of this study was to assess if a low-dose carotid computed tomography angiography (CTA) performed with pure iterative reconstruction (IR) is comparable to a conventional dose CTA protocol. Methods: Twenty patients were included. Radiation dose was divided into a low-dose acquisition reconstructed with pure IR and a conventional dose acquisition reconstructed with 40% hybrid IR. Dose, image noise, contrast resolution, spatial resolution, and carotid artery stenosis were measured. Results: Mean effective dose was significantly lower for low-dose than conventional do… περισσότερα » Computed Tomography Imaging of a Hip Prosthesis Using Iterative Model-Based Reconstruction and Orthopaedic Metal Artefact Reduction: A Quantitative Analysis. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objectives: To quantify the combined use of iterative model-based reconstruction (IMR) and orthopaedic metal artefact reduction (O-MAR) in reducing metal artefacts and improving image quality in a total hip arthroplasty phantom. Methods: Scans acquired at several dose levels and kVps were reconstructed with filtered back-projection (FBP), iterative reconstruction (iDose4) and IMR, with and without O-MAR. Computed tomography (CT) numbers, noise levels, signal-to-noise-ratios and contrast-to-noise-ratios were analysed. Results: Iterative model-based reconstruction results in overall i… περισσότερα » Regional Lung Ventilation Analysis Using Temporally Resolved Magnetic Resonance Imaging. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: We propose a computer-aided method for regional ventilation analysis and observation of lung diseases in temporally resolved magnetic resonance imaging (4D MRI). Methods: A shape model-based segmentation and registration workflow was used to create an atlas-derived reference system in which regional tissue motion can be quantified and multimodal image data can be compared regionally. Model-based temporal registration of the lung surfaces in 4D MRI data was compared with the registration of 4D computed tomography (CT) images. A ventilation analysis was performed on 4D MR i… περισσότερα » Active Surveillance of Small Renal Masses: A Review on the Role of Imaging With a Focus on Growth Rate. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: This study aimed to systematically summarize the current literature in the field of active surveillance for small renal masses, with the primary focus being the role of imaging in the primary decision-making and subsequent follow-up. Materials: A systematic review of the electronic databases PubMed and Web of Knowledge was performed according to Preferred Reporting Items for Systematic Reviews and Meta-analysis statement guidelines. Variables were extracted from the data set and included the following: (1) patient demographics, (2) tumor characteristics, and (3) study des… περισσότερα » Renal Cell Carcinoma: Accuracy of Multidetector Computed Tomography in the Assessment of Renal Sinus Fat Invasion. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Purpose: The purpose of this study was to evaluate the accuracy of multidetector computed tomography (MDCT) in the preoperative assessment of renal sinus fat invasion (RSFI) in patients with renal cell carcinoma (RCC) and to assess imaging features that improve detection of RSFI on CT. Methods: This is a single-institution retrospective review of 53 consecutive patients with histologically proven RCC who underwent triple-phase preoperative contrast MDCT prior to partial or radical nephrectomy. Two experienced radiologists (R1 and R2), blinded to the final histology result, independe… περισσότερα » Cystic Cervicitis: A Case Report and Literature Review of Cystic Cervical Lesions. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα We present a case of a 30-year-old woman who, while undergoing infertility evaluation, was found to have a large cystic cervical mass, shown to be cystic cervicitis on cervical cone biopsy. Differential diagnosis for benign cystic cervical lesions includes Nabothian cysts, tunnel cluster, endocervical hyperplasia, and cervicitis, whereas cystic cervical malignancies include adenocarcinoma and adenoma malignum. While it is crucial to differentiate benign from malignant lesions, imaging characteristics often overlap and may not provide a specific diagnosis. In difficult cases, definit… περισσότερα » Contrast-Enhanced Dixon Fat-Water Separation Imaging of the Spine: Added Value of Fat, In-Phase and Opposed-Phase Imaging in Marrow Lesion Detection. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: Beyond fat suppression (FS), the efficacy of (fat-water separation or Dixon [FWD]) Dixon imaging in gadolinium-enhanced spine imaging has yet to be validated. This study evaluated enhanced opposed-phase (OP) and fat-only (FO) images along with water-only (WO; FS) images against traditional unenhanced techniques and rated the incremental value of in-phase imaging in patients with presumed neoplastic focal spine lesions. Methods: A retrospective cohort study of 36 subjects with focal spine lesions imaged with FWD was evaluated qualitatively and quantitatively. Results: Enha… περισσότερα » Comparison of Knowledge-based Iterative Model Reconstruction and Hybrid Reconstruction Techniques for Liver CT Evaluation of Hypervascular Hepatocellular Carcinoma. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: The purpose of this work was to evaluate the image quality, lesion conspicuity, and dose reduction provided by knowledge-based iterative model reconstruction (IMR) in computed tomography (CT) of the liver compared with hybrid iterative reconstruction (IR) and filtered back projection (FBP) in patients with hepatocellular carcinoma (HCC). Methods: Fifty-six patients with 61 HCCs who underwent multiphasic reduced-dose CT (RDCT; n = 33) or standard-dose CT (SDCT; n = 28) were retrospectively evaluated. Reconstructed images with FBP, hybrid IR (iDose4), IMR were evaluated for… περισσότερα » Periprosthetic Artifact Reduction Using Virtual Monochromatic Imaging Derived From Gemstone Dual-Energy Computed Tomography and Dedicated Software. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Objective: The aim of this study was to explore the usefulness of combined virtual monochromatic imaging and metal artifact reduction software (MARS) for the evaluation of musculoskeletal periprosthetic tissue. Methods: Measurements were performed in periprosthetic and remote regions in 80 patients using a high-definition scanner. Polychromatic images with and without MARS and virtual monochromatic images were obtained. Results: Periprosthetic polychromatic imaging (PI) showed significant differences compared with remote areas among the 3 tissues explored (P from #Medicine via ola K… περισσότερα » Volumetric Single-Beat Coronary Computed Tomography Angiography: Relationship of Image Quality, Heart Rate, and Body Mass Index. Initial Patient Experience With a New Computed Tomography Scanner. Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Background: Cardiac computed tomography (CT) image quality (IQ) is very important for accurate diagnosis. We propose to evaluate IQ expressed as Likert scale, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) from coronary CT angiography images acquired with a new volumetric single-beat CT scanner on consecutive patients and assess the IQ dependence on heart rate (HR) and body mass index (BMI). Methods: We retrospectively analyzed the data of the first 439 consecutive patients (mean age, 55.13 [SD, 12.1] years; 51.47% male), who underwent noninvasive coronary CT angiogr… περισσότερα » Cell Host & Microbe Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 31 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Cell Host & Microbe *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your compu… περισσότερα » Current Opinion in Immunology Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 31 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Current Opinion in Immunology *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to … περισσότερα » Cell Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Cell via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can … περισσότερα » Cell Reports Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Cell Reports *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and… περισσότερα » Cell Metabolism Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Cell Metabolism *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer … περισσότερα » Behavioral and Psychological Symptoms and Caregiver Burden in Mexican Alzheimer's Disease Patients sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
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Myelin Oligodendrocyte Glycoprotein induces incomplete tolerance of CD4+ T cells specific for both a myelin and a neuronal self antigen in mice
T-cell polyspecificity, predicting that individual T cells recognize a continuum of related ligands, implies that multiple antigens can tolerize T cells specific for a given self-antigen. We previously showed in C57BL/6 mice that part of the CD4+ T-cell repertoire specific for myelin oligodendrocyte glycoprotein (MOG) 35–55 also recognizes the neuronal antigen neurofilament medium (NF-M) 15–35. Such bi-specific CD4+ T cells are frequent and produce inflammatory cytokines after stimulation. Since T cells recognizing two self-antigens would be expected to be tolerized more efficiently, this finding prompted us to study how polyspecificity impacts tolerance. We found that similar to MOG, NF-M is expressed in the thymus by medullary thymic epithelial cells, a tolerogenic population. Nevertheless, the frequency, phenotype, and capacity to transfer experimental encephalomyelitis (EAE) of MOG35-55-reactive CD4+ T cells were increased in MOG-deficient but not in NF-M-deficient mice. We found that presentation of NF-M15-35 by I-Ab on dendritic cells is of short duration, suggesting unstable MHC class II binding. Consistently, introducing an MHC-anchoring residue into NF-M15-35 (NF-M15-35T20Y) increased its immunogenicity, activating a repertoire able to induce EAE. Our results show that in C57BL/6 mice bi-specific encephalitogenic T cells manage to escape tolerization due to inefficient exposure to two self-antigens.
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Proteomic analysis of docetaxel resistance in human nasopharyngeal carcinoma cells using the two-dimensional gel electrophoresis method.
Docetaxel-based chemotherapy has been recommended for advanced nasopharyngeal carcinoma (NPC). However, treatment failure often occurs because of acquired drug resistance. In this study, a docetaxel-resistant NPC cell line CNE-2R was established with increasing doses of docetaxel for more than 6 months. Two-dimensional gel electrophoresis and ESI-Q-TOF-MS were used to compare the differential expression of docetaxel-resistance-associated proteins between human NPC CNE-2 cells and docetaxel-resistant CNE-2R cells. As a result, 24 differentially expressed proteins were identified, including 11 proteins with increased expression and 13 proteins with decreased expression. These proteins function in diverse biological processes such as metabolism, signal transduction, calcium ion binding, immune response, proteolysis, and so on. Among these, [alpha]-enolase (ENO1), significantly upregulated in CNE-2R, was selected for detailed analysis. Inhibition of ENO1 by shRNA restored CNE-2R cells' sensitivity to docetaxel. Moreover, overexpression of ENO1 could facilitate the development of acquired resistance of docetaxel in CNE-2 cells. Western blot and reverse-transcription PCR data of clinical samples confirmed that [alpha]-enolase was upregulated in docetaxel-resistant human NPC tissues. Finding such proteins might improve interpretation of the molecular mechanisms leading to the acquisition of docetaxel chemoresistance. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
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Paralleled comparison of vectors for the generation of CAR-T cells.
T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches, several gene-transfer methods were used to deliver CARs or other genes into T-lymphocytes, equipping CAR-modified T cells with a property of recognizing and attacking antigen-expressing tumor cells in a major histocompatibility complex-independent manner. Here, we summarize the gene-transfer vectors commonly used in the generation of CAR-T cell, including retrovirus vectors, lentivirus vectors, the transposon/transposase system, the plasmid-based system, and the messenger RNA electroporation system. The following aspects were compared in parallel: efficiency of gene transfer, the integration methods in the modified T cells, foreground of scale-up production, and application and development in clinical trials. These aspects should be taken into account to generate the optimal CAR-gene vector that may be suitable for future clinical application. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
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Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types
Background: Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear.
Methods: Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated clonal diversity of B-cell infiltrates through calculating B-cell receptor (BCR) repertoire sequence diversity. All statistical tests were two-sided.
Results: High expression of T-cell and B-cell signatures predicted improved overall survival across many tumor types including breast, lung, and melanoma (breast CD8_T_Cells hazard ratio [HR] = 0.36, 95% confidence interval [CI] = 0.16 to 0.81, P = .01; lung adenocarcinoma B_Cell_60gene HR = 0.71, 95% CI = 0.58 to 0.87, P = 7.80E-04; melanoma LCK HR = 0.86, 95% CI = 0.79 to 0.94, P = 6.75E-04). Macrophage signatures predicted worse survival in GBM, as did B-cell signatures in renal tumors (Glioblastoma Multiforme [GBM]: macrophages HR = 1.62, 95% CI = 1.17 to 2.26, P = .004; renal: B_Cell_60gene HR = 1.17, 95% CI = 1.04 to 1.32, P = .009). BCR diversity was associated with survival beyond gene segment expression in melanoma (HR = 2.67, 95% CI = 1.32 to 5.40, P = .02) and renal cell carcinoma (HR = 0.36, 95% CI = 0.15 to 0.87, P = .006).
Conclusions: These data support existing studies suggesting that in diverse tissue types, heterogeneous immune infiltrates are present and typically portend an improved prognosis. In some tumor types, BCR diversity was also associated with survival. Quantitative genomic signatures of immune cells warrant further testing as prognostic markers and potential biomarkers of response to cancer immunotherapy.
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Methods: Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated clonal diversity of B-cell infiltrates through calculating B-cell receptor (BCR) repertoire sequence diversity. All statistical tests were two-sided.
Results: High expression of T-cell and B-cell signatures predicted improved overall survival across many tumor types including breast, lung, and melanoma (breast CD8_T_Cells hazard ratio [HR] = 0.36, 95% confidence interval [CI] = 0.16 to 0.81, P = .01; lung adenocarcinoma B_Cell_60gene HR = 0.71, 95% CI = 0.58 to 0.87, P = 7.80E-04; melanoma LCK HR = 0.86, 95% CI = 0.79 to 0.94, P = 6.75E-04). Macrophage signatures predicted worse survival in GBM, as did B-cell signatures in renal tumors (Glioblastoma Multiforme [GBM]: macrophages HR = 1.62, 95% CI = 1.17 to 2.26, P = .004; renal: B_Cell_60gene HR = 1.17, 95% CI = 1.04 to 1.32, P = .009). BCR diversity was associated with survival beyond gene segment expression in melanoma (HR = 2.67, 95% CI = 1.32 to 5.40, P = .02) and renal cell carcinoma (HR = 0.36, 95% CI = 0.15 to 0.87, P = .006).
Conclusions: These data support existing studies suggesting that in diverse tissue types, heterogeneous immune infiltrates are present and typically portend an improved prognosis. In some tumor types, BCR diversity was also associated with survival. Quantitative genomic signatures of immune cells warrant further testing as prognostic markers and potential biomarkers of response to cancer immunotherapy.
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Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types
Background: Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear.
Methods: Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated clonal diversity of B-cell infiltrates through calculating B-cell receptor (BCR) repertoire sequence diversity. All statistical tests were two-sided.
Results: High expression of T-cell and B-cell signatures predicted improved overall survival across many tumor types including breast, lung, and melanoma (breast CD8_T_Cells hazard ratio [HR] = 0.36, 95% confidence interval [CI] = 0.16 to 0.81, P = .01; lung adenocarcinoma B_Cell_60gene HR = 0.71, 95% CI = 0.58 to 0.87, P = 7.80E-04; melanoma LCK HR = 0.86, 95% CI = 0.79 to 0.94, P = 6.75E-04). Macrophage signatures predicted worse survival in GBM, as did B-cell signatures in renal tumors (Glioblastoma Multiforme [GBM]: macrophages HR = 1.62, 95% CI = 1.17 to 2.26, P = .004; renal: B_Cell_60gene HR = 1.17, 95% CI = 1.04 to 1.32, P = .009). BCR diversity was associated with survival beyond gene segment expression in melanoma (HR = 2.67, 95% CI = 1.32 to 5.40, P = .02) and renal cell carcinoma (HR = 0.36, 95% CI = 0.15 to 0.87, P = .006).
Conclusions: These data support existing studies suggesting that in diverse tissue types, heterogeneous immune infiltrates are present and typically portend an improved prognosis. In some tumor types, BCR diversity was also associated with survival. Quantitative genomic signatures of immune cells warrant further testing as prognostic markers and potential biomarkers of response to cancer immunotherapy.
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Methods: Using mRNA sequencing data from The Cancer Genome Atlas (TCGA) from 11 tumor types representing 3485 tumors, we evaluated lymphocyte and macrophage gene expression by tissue type and by genomic subtypes defined within and across tumor tissue of origin (Cox proportional hazards, Pearson correlation). We investigated clonal diversity of B-cell infiltrates through calculating B-cell receptor (BCR) repertoire sequence diversity. All statistical tests were two-sided.
Results: High expression of T-cell and B-cell signatures predicted improved overall survival across many tumor types including breast, lung, and melanoma (breast CD8_T_Cells hazard ratio [HR] = 0.36, 95% confidence interval [CI] = 0.16 to 0.81, P = .01; lung adenocarcinoma B_Cell_60gene HR = 0.71, 95% CI = 0.58 to 0.87, P = 7.80E-04; melanoma LCK HR = 0.86, 95% CI = 0.79 to 0.94, P = 6.75E-04). Macrophage signatures predicted worse survival in GBM, as did B-cell signatures in renal tumors (Glioblastoma Multiforme [GBM]: macrophages HR = 1.62, 95% CI = 1.17 to 2.26, P = .004; renal: B_Cell_60gene HR = 1.17, 95% CI = 1.04 to 1.32, P = .009). BCR diversity was associated with survival beyond gene segment expression in melanoma (HR = 2.67, 95% CI = 1.32 to 5.40, P = .02) and renal cell carcinoma (HR = 0.36, 95% CI = 0.15 to 0.87, P = .006).
Conclusions: These data support existing studies suggesting that in diverse tissue types, heterogeneous immune infiltrates are present and typically portend an improved prognosis. In some tumor types, BCR diversity was also associated with survival. Quantitative genomic signatures of immune cells warrant further testing as prognostic markers and potential biomarkers of response to cancer immunotherapy.
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Orbital Recurrence of Ethmoid Sinus Malignant Meningioma: Case Study and Literature Review.
The authors describe a case of a recurrent World Health Organization grade III extradural, sinonasal meningioma that presented with epiphoria. Primary extradural meningiomas are rare, comprising only 1% to 2% of all meningiomas.1 These tumors are diagnosed and graded histologically according to the World Health Organization criteria.2 Grade III tumors are very malignant with high recurrence and death rates.3 This case highlights the rarity of sinonasal tract meningiomas involving the orbit. In addition, it shows the poor prognosis of such malignant disease and the need for a multidisciplinary approach. Collection and evaluation of protected patient health information for this report was in compliance with the Health Insurance Portability and Accountability Act and approved by the Institutional Review Board of Northwestern University Feinberg School of Medicine. Research adhered to the tenets of the Declaration of Helsinki. (C) 2016 by The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc., All rights reserved.
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Malar Reconstruction Using Y-V Advancement Flaps after Tissue Expansion in Treacher Collins Syndrome
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Color Atlas and Synopsis of Pediatric Dermatology, 3rd edn. Sandipan Dhar, ed. Delhi: Jaypee Brothers Medical Publishers, 2015. ISBN: 978-935-152632-2. Price £116.
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Sequential incremental doses of bisacodyl increase the diagnostic accuracy of colonic manometry
Abstract
Background
Colonic manometry is the standard diagnostic modality for evaluating colonic motility in children. Intraluminal bisacodyl is routinely used to trigger high-amplitude propagating contractions (HAPCs), a feature of normal colonic motility. Usually, only a single dose (0.2 mg/kg) is suggested. We retrospectively explored whether the use of an additional higher (0.4 mg/kg) dose of bisacodyl increases the yield of colonic manometry.
Methods
In 103 children (median age: 8.8 years, range 3.2–15.7 years) with a diagnosis of slow transit constipation, colonic motility was recorded for 1 h before and 1 h after each of two incremental doses of bisacodyl (low, L, dose: 0.2 mg/kg, max 10 mg; high, H, dose: 0.4 mg/kg, max 20 mg) and the characteristics of HAPCs analyzed.
Key Results
High-amplitude propagating contractions were seen in 85 children. H dose significantly increased the proportion of patients with fully propagated HAPCs (H dose: 57/103 [55%], L dose: 27/103 [26%], p < 0.001), paralleling the significant decrease in the proportion with partially propagated HAPCs (H dose: 29/103 [28%], L dose: 47/103 [46%], p < 0.01). Mean HAPC number significantly increased throughout the colon at H compared to L dose (7.2 ± 5.05 vs 5.6 ± 5.1, p < 0.05). Finally, the proportion of patients with normal pressure wave morphology of HAPCs significantly increased with higher dose (H dose: 55/85 [65%], L dose: 27/85 [32%], p < 0.001).
Conclusions & Interferences
An additional higher dose of bisacodyl during colonic manometry improves colonic neuromuscular function suggesting its use might improve interpretation and decision making in children with slow transit constipation.
We retrospectively explored whether the use of sequential incremental dose of bisacodyl given during the colonic manometry increases the yield of the test. An additional high dose of bisacodyl improves colonic neuromuscular function by increasing the proportion of patients with fully propagated high-amplitude propagating contractions (HAPCs) and their morphology. Our data suggest that the use of sequential incremental dose of bisacodyl during colonic manometry might significantly impact the management of children with refractory slow transit constipation.
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Orbital Recurrence of Ethmoid Sinus Malignant Meningioma: Case Study and Literature Review.
The authors describe a case of a recurrent World Health Organization grade III extradural, sinonasal meningioma that presented with epiphoria. Primary extradural meningiomas are rare, comprising only 1% to 2% of all meningiomas.1 These tumors are diagnosed and graded histologically according to the World Health Organization criteria.2 Grade III tumors are very malignant with high recurrence and death rates.3 This case highlights the rarity of sinonasal tract meningiomas involving the orbit. In addition, it shows the poor prognosis of such malignant disease and the need for a multidisciplinary approach. Collection and evaluation of protected patient health information for this report was in compliance with the Health Insurance Portability and Accountability Act and approved by the Institutional Review Board of Northwestern University Feinberg School of Medicine. Research adhered to the tenets of the Declaration of Helsinki. © 2016 by The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc., All rights reserved.
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Sequential incremental doses of bisacodyl increase the diagnostic accuracy of colonic manometry
Abstract
Background
Colonic manometry is the standard diagnostic modality for evaluating colonic motility in children. Intraluminal bisacodyl is routinely used to trigger high-amplitude propagating contractions (HAPCs), a feature of normal colonic motility. Usually, only a single dose (0.2 mg/kg) is suggested. We retrospectively explored whether the use of an additional higher (0.4 mg/kg) dose of bisacodyl increases the yield of colonic manometry.
Methods
In 103 children (median age: 8.8 years, range 3.2–15.7 years) with a diagnosis of slow transit constipation, colonic motility was recorded for 1 h before and 1 h after each of two incremental doses of bisacodyl (low, L, dose: 0.2 mg/kg, max 10 mg; high, H, dose: 0.4 mg/kg, max 20 mg) and the characteristics of HAPCs analyzed.
Key Results
High-amplitude propagating contractions were seen in 85 children. H dose significantly increased the proportion of patients with fully propagated HAPCs (H dose: 57/103 [55%], L dose: 27/103 [26%], p < 0.001), paralleling the significant decrease in the proportion with partially propagated HAPCs (H dose: 29/103 [28%], L dose: 47/103 [46%], p < 0.01). Mean HAPC number significantly increased throughout the colon at H compared to L dose (7.2 ± 5.05 vs 5.6 ± 5.1, p < 0.05). Finally, the proportion of patients with normal pressure wave morphology of HAPCs significantly increased with higher dose (H dose: 55/85 [65%], L dose: 27/85 [32%], p < 0.001).
Conclusions & Interferences
An additional higher dose of bisacodyl during colonic manometry improves colonic neuromuscular function suggesting its use might improve interpretation and decision making in children with slow transit constipation.
We retrospectively explored whether the use of sequential incremental dose of bisacodyl given during the colonic manometry increases the yield of the test. An additional high dose of bisacodyl improves colonic neuromuscular function by increasing the proportion of patients with fully propagated high-amplitude propagating contractions (HAPCs) and their morphology. Our data suggest that the use of sequential incremental dose of bisacodyl during colonic manometry might significantly impact the management of children with refractory slow transit constipation.
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Low-Dose Carotid Computed Tomography Angiography Using Pure Iterative Reconstruction.
Low-Dose Carotid Computed Tomography Angiography Using Pure Iterative Reconstruction.: Objective: The aim of this study was to assess if a low-dose carotid computed tomography angiography (CTA) performed with pure iterative reconstruction (IR) is comparable to a conventional dose CTA protocol. Methods: Twenty patients were included. Radiation dose was divided into a low-dose acquisition reconstructed with pure IR and a conventional dose acquisition reconstructed with 40% hybrid IR. Dose, image noise, contrast resolution, spatial resolution, and carotid artery stenosis were measured. Results: Mean effective dose was significantly lower for low-dose than conventional dose studies (1.84 versus 3.71 mSv; P
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Computed Tomography Imaging of a Hip Prosthesis Using Iterative Model-Based Reconstruction and Orthopaedic Metal Artefact Reduction: A Quantitative Analysis.
Computed Tomography Imaging of a Hip Prosthesis Using Iterative Model-Based Reconstruction and Orthopaedic Metal Artefact Reduction: A Quantitative Analysis.: Objectives: To quantify the combined use of iterative model-based reconstruction (IMR) and orthopaedic metal artefact reduction (O-MAR) in reducing metal artefacts and improving image quality in a total hip arthroplasty phantom. Methods: Scans acquired at several dose levels and kVps were reconstructed with filtered back-projection (FBP), iterative reconstruction (iDose4) and IMR, with and without O-MAR. Computed tomography (CT) numbers, noise levels, signal-to-noise-ratios and contrast-to-noise-ratios were analysed. Results: Iterative model-based reconstruction results in overall improved image quality compared to iDose4 and FBP (P
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Regional Lung Ventilation Analysis Using Temporally Resolved Magnetic Resonance Imaging.
Regional Lung Ventilation Analysis Using Temporally Resolved Magnetic Resonance Imaging.: Objective: We propose a computer-aided method for regional ventilation analysis and observation of lung diseases in temporally resolved magnetic resonance imaging (4D MRI). Methods: A shape model-based segmentation and registration workflow was used to create an atlas-derived reference system in which regional tissue motion can be quantified and multimodal image data can be compared regionally. Model-based temporal registration of the lung surfaces in 4D MRI data was compared with the registration of 4D computed tomography (CT) images. A ventilation analysis was performed on 4D MR images of patients with lung fibrosis; 4D MR ventilation maps were compared with corresponding diagnostic 3D CT images of the patients and 4D CT maps of subjects without impaired lung function (serving as reference). Results: Comparison between the computed patient-specific 4D MR regional ventilation maps and diagnostic CT images shows good correlation in conspicuous regions. Comparison to 4D CT-derived ventilation maps supports the plausibility of the 4D MR maps. Dynamic MRI-based flow-volume loops and spirograms further visualize the free-breathing behavior. Conclusions: The proposed methods allow for 4D MR-based regional analysis of tissue dynamics and ventilation in spontaneous breathing and comparison of patient data. The proposed atlas-based reference coordinate system provides an automated manner of annotating and comparing multimodal lung image data. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
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Active Surveillance of Small Renal Masses: A Review on the Role of Imaging With a Focus on Growth Rate.
Active Surveillance of Small Renal Masses: A Review on the Role of Imaging With a Focus on Growth Rate.: Objective: This study aimed to systematically summarize the current literature in the field of active surveillance for small renal masses, with the primary focus being the role of imaging in the primary decision-making and subsequent follow-up. Materials: A systematic review of the electronic databases PubMed and Web of Knowledge was performed according to Preferred Reporting Items for Systematic Reviews and Meta-analysis statement guidelines. Variables were extracted from the data set and included the following: (1) patient demographics, (2) tumor characteristics, and (3) study design. Results: Twenty-one articles studying imaging in active surveillance of small renal masses were selected. Seventy-two percent (15/21) of studies were retrospective; 19% (4/21) were prospective; and 9% (2/21) studies were bidirectional. Mean age of patients was 69 years (range, 57-81 years). A total of 1386 patients were in the study; 59% of patients were men. Mean follow-up was 39 months (range, 18.8-91.5 months). Sixty-seven percent of masses discussed in this review were followed up using more than one imaging modality; 19% consistently used computed tomography for follow-up whereas the remaining 14% did not specify what imaging modality was used. Imaging studies were reviewed by the investigators centrally in 86% (18/21). In 14% of the studies, only imaging report was reviewed. Biopsy was performed in 24% of masses. Mean growth rate for all tumors was 0.27 cm/y (range, 0.06-0.7 cm/y). For studies where growth rate of benign and malignant masses were differentiated, mean growth rate for benign masses was 0.3 cm/y and mean growth rate for malignant masses was 0.35 cm/y. Conclusions: Growth rate is often used as a discriminant in following up a small renal mass in patients undergoing active surveillance. However, there is great variability in growth rate and it alone is not an adequate marker for determining whether the tumor is malignant. Because very few studies specified radiological characteristics of small renal masses, future studies can be done to better characterize masses. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
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Renal Cell Carcinoma: Accuracy of Multidetector Computed Tomography in the Assessment of Renal Sinus Fat Invasion.
Renal Cell Carcinoma: Accuracy of Multidetector Computed Tomography in the Assessment of Renal Sinus Fat Invasion.: Purpose: The purpose of this study was to evaluate the accuracy of multidetector computed tomography (MDCT) in the preoperative assessment of renal sinus fat invasion (RSFI) in patients with renal cell carcinoma (RCC) and to assess imaging features that improve detection of RSFI on CT. Methods: This is a single-institution retrospective review of 53 consecutive patients with histologically proven RCC who underwent triple-phase preoperative contrast MDCT prior to partial or radical nephrectomy. Two experienced radiologists (R1 and R2), blinded to the final histology result, independently reviewed the preoperative MDCT studies to assess for RSFI. Histopathology was used as the gold standard for the presence of RSFI. Results: Of 55 surgically resected RCCs that were evaluated with contrast-enhanced MDCT, 34.5% (19/55) of RCCs had RSFI on final histopathology. Multidetector CT demonstrated high sensitivity (R1, 100%; R2, 93.7%) for the detection of RSFI, but a low positive predictive value (R1, 40%; R2, 53%) and specificity (R1, 38.4%; R2, 66.6%). Interreader agreement for RSFI was moderate ([kappa] = 0.56). Renal tumors were significantly larger in cases with RSFI (6.3 +/- 3.219 cm) than tumors without RSFI (4.1 +/- 2.9 cm) (P = 0.0275). Renal sinus fat invasion was more commonly associated to an irregular tumor margin at the tumor renal sinus fat interface (P
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Cystic Cervicitis: A Case Report and Literature Review of Cystic Cervical Lesions.
Cystic Cervicitis: A Case Report and Literature Review of Cystic Cervical Lesions.: We present a case of a 30-year-old woman who, while undergoing infertility evaluation, was found to have a large cystic cervical mass, shown to be cystic cervicitis on cervical cone biopsy. Differential diagnosis for benign cystic cervical lesions includes Nabothian cysts, tunnel cluster, endocervical hyperplasia, and cervicitis, whereas cystic cervical malignancies include adenocarcinoma and adenoma malignum. While it is crucial to differentiate benign from malignant lesions, imaging characteristics often overlap and may not provide a specific diagnosis. In difficult cases, definitive diagnosis should be based on clinical presentation and cervical biopsy. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
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