Effect of a single dose vitamin D3 on postprandial arterial stiffness and inflammation in vitamin D deficient women.

Related Articles

Effect of a single dose vitamin D3 on postprandial arterial stiffness and inflammation in vitamin D deficient women.

J Clin Endocrinol Metab. 2016 Dec 22;:jc20163394

Authors: de Vries MA, van der Meulen N, van de Geijn GM, Klop B, van der Zwan EM, Prinzen L, Birnie E, Westerman EM, de Herder WW, Castro Cabezas M

Abstract
CONTEXT: Cholecalciferol (vitamin D3) may improve vascular function and reduce inflammation, potentially providing an explanation for the proposed cardiovascular protection by vitamin D .
OBJECTIVE: We investigated whether cholecalciferol supplementation reduces postprandial arterial dysfunction and inflammation.
DESIGN: This was a randomized 1:1, double blind trial.
SETTING: The study was conducted in the Diabetes and Vascular Center of the Franciscus Gasthuis, Rotterdam, The Netherlands.
PATIENTS: Twenty-four healthy premenopausal, overweight or obese, vitamin D deficient women.
INTERVENTIONS: A single high (300 000 IU) or low dose (75 000 IU) cholecalciferol.
MAIN OUTCOME MEASURES: The effect of low and high dose cholecalciferol on postprandial leukocyte activation markers, pulse wave velocity (PWV) and augmentation index (AIx) during an oral fat loading test, expressed as area under the curve (AUC).
RESULTS: High and low dose supplementation increased vitamin D by 163±134%, p<0.001 and 66±59%, p<0.001, respectively. Monocyte CD11b-AUC slightly increased after low but not high dose (+6±2%, p=0.012 and +4±1%, p=0.339 respectively). There were no significant effects on postprandial PWV or AIx by high or low dose vitamin D. Fasting complement component 3 (C3) levels decreased by 5.9% (p=0.004) in the high dose, and by 4.0% (p=0.018) in the low dose group.
CONCLUSIONS: A single dose of vitamin D does not seem to reduce arterial stiffness and leukocyte activation in overweight, vitamin D deficient women. Fasting C3 may decrease by vitamin D. Possibly, higher vitamin D concentrations may be needed to decrease inflammation and improve vascular function in overweight or obese vitamin D deficient women.

PMID: 28005440 [PubMed - as supplied by publisher]

http://ift.tt/2hzGloc