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The inion response revisited: evidence for a possible cerebellar contribution to vestibular evoked potentials produced by air conducted sound stimulation.
J Neurophysiol. 2016 Dec 14;:jn.00545.2016
Authors: Todd NP, Govender S, Colebatch JG
Abstract
This study investigated the effect of eye gaze and head position on vestibular evoked potentials (VsEPs). Head position would be expected to affect myogenic sources and eye position is known to affect ocular myogenic responses (OVEMPs), whereas a neurogenic source should behave otherwise. 11 healthy subjects were recruited and VsEPs using 72 channel EEG were recorded at a fixed intensity above the vestibular threshold. Three eye gaze and three head positions were tested (-20°, 0° and+20° to the horizontal). Short latency potentials showed that in addition to the expected effect of gaze on infra-ocular (IO') leads, where up-gaze gives a maximum response, significant changes in amplitude were also observed in electrodes remote from the eyes, and in particular from contralateral parietal-occipital (PO) and neck (CB') leads. Short latency potentials of similar latency were observed (p10/n17 and n10/p17 respectively). The pattern of change with gaze in the PO leads was distinct from that observed for the IO' leads. For the PO leads the maximum response was obtained with neutral gaze, and this was also distinct from that observed for CB' electrodes, where a maximal response was observed with head flexion in the second wave, but not the first. Evidence of modulation of N42 and N1 potentials with both eye and head position was also observed. Head and eye position manipulation thus suggests that the inion response consists of an early neurogenic component as well as myogenic responses. The p10/n17 at PO in particular may be an indicator of vestibulo-cerebellar projections.
PMID: 27974448 [PubMed - as supplied by publisher]
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