Lynamicin D an Antimicrobial Natural Product Affects Splicing by Inducing the Expression of SR Protein Kinase 1

Publication date: Available online 19 January 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Ioanna Sigala, George Ganidis, Savvas Thysiadis, Alexandros L. Zografos, Thomas Giannakouros, Vasiliki Sarli, Eleni Nikolakaki
The first total synthesis of the antimicrobial natural product lynamicin D has been developed using a Suzuki coupling to construct the bisindole pyrrole skeleton. An evaluation of the biological activity of lynamicin D reveals that it has a minor effect on cell viability but it can modulate splicing of pre-mRNAs. We provide evidence that this effect is mainly due to the ability of lynamicin D to alter the levels of SRPK1, the key kinase involved in both constitutive and alternative splicing.

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