Pancreas and Not Gut Mediates the GLP-1-Induced Glucoincretin Effect

Publication date: 4 April 2017
Source:Cell Metabolism, Volume 25, Issue 4
Author(s): Joel F. Habener, Violeta Stanojevic
The gut is believed to be the source of GLP-1 that augments insulin secretion in response to oral nutrients. In this issue of Cell Metabolism, Chambers et al. (2017) shift the paradigm by finding that GLP-1 produced within the islets of the pancreas, and not the gut, is responsible for the incretin effect in mice.

Teaser

The gut is believed to be the source of GLP-1 that augments insulin secretion in response to oral nutrients. In this issue of Cell Metabolism, Chambers et al. (2017) shift the paradigm by finding that GLP-1 produced within the islets of the pancreas, and not the gut, is responsible for the incretin effect in mice.


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