Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape

Publication date: 18 April 2017
Source:Immunity, Volume 46, Issue 4
Author(s): William W. Agace, Kathy D. McCoy
The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life.

Teaser

Agace and McCoy discuss regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process, including evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life.


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