Objectives: Postmortem examination of temporal bones of Meniere's disease patients consistently show dilated endolymphatic spaces of the inner ear, for which the term endolymphatic hydrops has been coined. During the past decade, magnetic resonance imaging techniques for the inner ear appeared, advancing the diagnosis of Meniere's disease. They require, however, a field-strength of at least 3 T, are costly and not universally available. Alternative, noninvasive, cost-effective tests with high sensitivity and specifity for endolymphatic hydrops are desirable. In this study, we test the suitability of distortion product otoacoustic emissions (DPOAEs) for endolymphatic hydrops detection. Previous measurements of the commonly recorded cubic DPOAEs mainly register cochlear hearing loss and are not specific for Meniere's disease. Simultaneous recordings of cubic and quadratic DPOAEs might be more suitable to detect endolymphatic hydrops, because both DPOAE orders react differently to changes of the cochlear operating point as they might occur in Meniere's disease patients. Design: Cubic and quadratic DPOAEs were recorded in normal-hearing participants (N = 45) and in the affected and unaffected ears of patients with a diagnosis of definite Meniere's disease (N = 32). First, to assess the integrity of DPOAE-generating mechanisms, cubic DPOAE-grams were obtained with primary tone frequencies f2 between 1 and 8 kHz with primary tone levels l1 = 60 dB SPL and l2 = 50 dB SPL, and a fixed primary tone frequency ratio of 1.22. Then, cubic and quadratic DPOAEs were simultaneously recorded with primary tone levels l1 = l2 = 65 dB SPL and at primary tone frequencies f2 = 4 and 5 kHz, where f1 was successively varied such that the ratio f2/f1 ranged between 1.1 and 1.6 in 0.04 steps while quadratic and cubic DPOAE levels were extracted from the same recording. Results: Cubic DPOAEs were significantly reduced in the affected ears of Meniere's disease patients, and slightly reduced in the unaffected ears of Meniere's disease patients, relative to the ears of normal-hearing participants. In contrast, no significant changes could be seen in quadratic DPOAEs across the ears of normal-hearing participants and Meniere's disease patients. Conclusions: We could identify a relatively good preservation of quadratic DPOAE levels in relation to a reduction of cubic DPOAE levels as a potential noninvasive diagnostic approach in the early stage of suspected Meniere's disease. Future studies validating the differential diagnostic power of this parameter in control groups with nonhydropic forms of hearing loss are warranted. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
http://ift.tt/2uENTfw
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
-
▼
Ιουλίου
(7890)
-
▼
Ιουλ 03
(224)
- Metastatic sarcomatoid renal cell carcinoma manife...
- Ribosomal Chamber Music: Toward an Understanding o...
- Experimental Simulation of Clinical Borderline Sit...
- Investigation of Electrical Stimulation Levels Ove...
- A Comparison of Distortion Product Otoacoustic Emi...
- Regulation of the Immune System by Laminins
- Mucosal Bioengineering: Gut in a Dish
- Investigating pH based evaluation of fetal heart r...
- Development and application of a perioral force me...
- Treatment for the endocrine resistant breast cance...
- A regulatory role of androgen in ovarian steroidog...
- Innate function of house dust mite allergens: robu...
- Innate function of house dust mite allergens: robu...
- Innate function of house dust mite allergens: robu...
- Chemokine isoforms and processing in inflammation ...
- Assessment of obstructive sleep apnoea treatment s...
- Is oestrogen associated with mandibular condylar r...
- Impact of highly active antiretroviral therapy on ...
- Vitamin E Isoform γ-Tocotrienol Protects Against E...
- Inhibition of platelet-derived growth factor recep...
- Quantitative Analysis of Hepatic Microcirculation ...
- Alterations in nociception and morphine antinocice...
- Transabdominal Ultrasound Colonography for Detecti...
- Obese Heart Failure With Preserved Ejection Fracti...
- Long Noncoding RNA MANTIS Facilitates Endothelial ...
- Decoupling the effects of stiffness and fiber dens...
- Circulation Editors and Editorial Board.
- Grounding Cardio-Oncology in Basic and Clinical Sc...
- Evidence Supporting the Existence of a Distinct Ob...
- Physiology of Angina and Its Alleviation With Nitr...
- Nitroglycerine and Angina: Evolving Clinical Coron...
- Association Between Fetal Congenital Heart Defects...
- Preeclampsia and Fetal Congenital Heart Defects: S...
- Effect of Long-Term Metformin and Lifestyle in the...
- Long Noncoding RNAs and Angiogenesis: Regulatory I...
- Idiopathic Ventricular Fibrillation in a 29-Year-O...
- Melanocortin 1 Receptor Signaling Regulates Choles...
- Is Cardioprotection Dead?.
- Breaking Meeting News: ACC.17
- Letter by Cerit Regarding Article, "Recurrent Hosp...
- Response by Gibson and Fox to Letter Regarding Art...
- Letter by Koh Regarding Article, "Factorial Effect...
- Response by Watts et al to Letter Regarding Articl...
- Flow cytometry-based diagnosis of primary immunode...
- Differential effect of the overexpression of Rad2/...
- Editorial: REM sleep behavior disorder and obstruc...
- Back to sleep- or not: The impact of the supine po...
- Secondary encephalocele in infant following subdur...
- Absence of Relationship between Mitochondrial DNA ...
- Characterization of gliomas: from morphology to mo...
- Service evaluation of patients’ views on the Patie...
- Absence of Relationship between Mitochondrial DNA ...
- “Archers lip”: a lesion on the upper lip
- Medialization Laryngoplasty After Injection Augmen...
- “Prologues to a Bad Voice”: Effect of Vocal Hygien...
- Sarcoidosis Presenting as Bilateral Vocal Fold Imm...
- Does a face-bow lead to better occlusion in comple...
- Oxidative potential of PM2.5 during Atlanta rush h...
- Time-resolved analysis of particle emissions from ...
- Particulate matter from re-suspended mineral dust ...
- The association between Mycoplasma pneumoniae infe...
- Topographical projections from the nucleus basalis...
- Unusual metallic penile foreign body
- An unusual case of KBG syndrome with unique oral f...
- Laryngeal lipoma: a rare cause of acute intermitte...
- Case of pneumatosis intestinalis and hepatic porta...
- Access to essential paediatric eye surgery in the ...
- Pulmonary co-infection with Nocardia and Aspergill...
- A rare presentation of multiple dens invaginatus i...
- Thoracic vertebral osteomyelitis: an unusual compl...
- Endodontic retreatment of a mandibular first molar...
- Cold finger: urban frostbite in the UK
- Central nervous system infection with Acanthamoeba...
- Herbicide/Zn-Al-layered double hydroxide hybrid co...
- Biosynthesis of staphylococcal enterotoxin A by ge...
- Preparation of modified waterworks sludge particle...
- The Effect of Attention-Deficit/Hyperactivity Diso...
- Effects of a Conversation-Based Intervention on th...
- Cluster-Randomized Controlled Trial Evaluating the...
- Assessing the Importance of Lexical Tone Contour t...
- Case History Risk Factors for Specific Language Im...
- Ecologically Valid Assessment of Prospective Memor...
- Cytokine storms in infectious diseases
- Towards predicting the encoding capability of MR f...
- Oral submucous fibrosis—an increasing global healt...
- Effects of the GaAlAs diode laser (780 nm) on the ...
- Curcumin photodynamic effect in the treatment of t...
- Abnormal renal parenchyma accumulation of 123I MIB...
- Differentiation of low- and high-grade clear cell ...
- Utility of surveillance MRI in women with a person...
- Evaluation of white matter hypodensities on comput...
- Adjuvant radiochemotherapy in locally advanced gas...
- Indoleamine 2,3-dioxygenase and Iron are required ...
- Calcium hydroxide associated with a new vehicle: P...
- Efficacy of two mouthwashes with cetylpyridinium c...
- Reports of uncontrolled clinical trials for direct...
- Evaluation of deflection forces of orthodontic wir...
- The need for endodontic treatment and systemic cha...
- Immunohistochemical expression of TGF-β1 and MMP-9...
- Differential diagnosis and clinical management of ...
-
▼
Ιουλ 03
(224)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
-
▼
Ιουλίου
(7890)
-
▼
Ιουλ 03
(224)
- Metastatic sarcomatoid renal cell carcinoma manife...
- Ribosomal Chamber Music: Toward an Understanding o...
- Experimental Simulation of Clinical Borderline Sit...
- Investigation of Electrical Stimulation Levels Ove...
- A Comparison of Distortion Product Otoacoustic Emi...
- Regulation of the Immune System by Laminins
- Mucosal Bioengineering: Gut in a Dish
- Investigating pH based evaluation of fetal heart r...
- Development and application of a perioral force me...
- Treatment for the endocrine resistant breast cance...
- A regulatory role of androgen in ovarian steroidog...
- Innate function of house dust mite allergens: robu...
- Innate function of house dust mite allergens: robu...
- Innate function of house dust mite allergens: robu...
- Chemokine isoforms and processing in inflammation ...
- Assessment of obstructive sleep apnoea treatment s...
- Is oestrogen associated with mandibular condylar r...
- Impact of highly active antiretroviral therapy on ...
- Vitamin E Isoform γ-Tocotrienol Protects Against E...
- Inhibition of platelet-derived growth factor recep...
- Quantitative Analysis of Hepatic Microcirculation ...
- Alterations in nociception and morphine antinocice...
- Transabdominal Ultrasound Colonography for Detecti...
- Obese Heart Failure With Preserved Ejection Fracti...
- Long Noncoding RNA MANTIS Facilitates Endothelial ...
- Decoupling the effects of stiffness and fiber dens...
- Circulation Editors and Editorial Board.
- Grounding Cardio-Oncology in Basic and Clinical Sc...
- Evidence Supporting the Existence of a Distinct Ob...
- Physiology of Angina and Its Alleviation With Nitr...
- Nitroglycerine and Angina: Evolving Clinical Coron...
- Association Between Fetal Congenital Heart Defects...
- Preeclampsia and Fetal Congenital Heart Defects: S...
- Effect of Long-Term Metformin and Lifestyle in the...
- Long Noncoding RNAs and Angiogenesis: Regulatory I...
- Idiopathic Ventricular Fibrillation in a 29-Year-O...
- Melanocortin 1 Receptor Signaling Regulates Choles...
- Is Cardioprotection Dead?.
- Breaking Meeting News: ACC.17
- Letter by Cerit Regarding Article, "Recurrent Hosp...
- Response by Gibson and Fox to Letter Regarding Art...
- Letter by Koh Regarding Article, "Factorial Effect...
- Response by Watts et al to Letter Regarding Articl...
- Flow cytometry-based diagnosis of primary immunode...
- Differential effect of the overexpression of Rad2/...
- Editorial: REM sleep behavior disorder and obstruc...
- Back to sleep- or not: The impact of the supine po...
- Secondary encephalocele in infant following subdur...
- Absence of Relationship between Mitochondrial DNA ...
- Characterization of gliomas: from morphology to mo...
- Service evaluation of patients’ views on the Patie...
- Absence of Relationship between Mitochondrial DNA ...
- “Archers lip”: a lesion on the upper lip
- Medialization Laryngoplasty After Injection Augmen...
- “Prologues to a Bad Voice”: Effect of Vocal Hygien...
- Sarcoidosis Presenting as Bilateral Vocal Fold Imm...
- Does a face-bow lead to better occlusion in comple...
- Oxidative potential of PM2.5 during Atlanta rush h...
- Time-resolved analysis of particle emissions from ...
- Particulate matter from re-suspended mineral dust ...
- The association between Mycoplasma pneumoniae infe...
- Topographical projections from the nucleus basalis...
- Unusual metallic penile foreign body
- An unusual case of KBG syndrome with unique oral f...
- Laryngeal lipoma: a rare cause of acute intermitte...
- Case of pneumatosis intestinalis and hepatic porta...
- Access to essential paediatric eye surgery in the ...
- Pulmonary co-infection with Nocardia and Aspergill...
- A rare presentation of multiple dens invaginatus i...
- Thoracic vertebral osteomyelitis: an unusual compl...
- Endodontic retreatment of a mandibular first molar...
- Cold finger: urban frostbite in the UK
- Central nervous system infection with Acanthamoeba...
- Herbicide/Zn-Al-layered double hydroxide hybrid co...
- Biosynthesis of staphylococcal enterotoxin A by ge...
- Preparation of modified waterworks sludge particle...
- The Effect of Attention-Deficit/Hyperactivity Diso...
- Effects of a Conversation-Based Intervention on th...
- Cluster-Randomized Controlled Trial Evaluating the...
- Assessing the Importance of Lexical Tone Contour t...
- Case History Risk Factors for Specific Language Im...
- Ecologically Valid Assessment of Prospective Memor...
- Cytokine storms in infectious diseases
- Towards predicting the encoding capability of MR f...
- Oral submucous fibrosis—an increasing global healt...
- Effects of the GaAlAs diode laser (780 nm) on the ...
- Curcumin photodynamic effect in the treatment of t...
- Abnormal renal parenchyma accumulation of 123I MIB...
- Differentiation of low- and high-grade clear cell ...
- Utility of surveillance MRI in women with a person...
- Evaluation of white matter hypodensities on comput...
- Adjuvant radiochemotherapy in locally advanced gas...
- Indoleamine 2,3-dioxygenase and Iron are required ...
- Calcium hydroxide associated with a new vehicle: P...
- Efficacy of two mouthwashes with cetylpyridinium c...
- Reports of uncontrolled clinical trials for direct...
- Evaluation of deflection forces of orthodontic wir...
- The need for endodontic treatment and systemic cha...
- Immunohistochemical expression of TGF-β1 and MMP-9...
- Differential diagnosis and clinical management of ...
-
▼
Ιουλ 03
(224)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου