Background. Many drugs used for cancer chemotherapy produce reactive oxygen species, thus leading to various complications including nephrotoxicity, cardiotoxicity, and ototoxicity. Objective. We have provided a haplogroup analysis of a cohort of cancer patients treated with chemotherapy and compared factors associated with associated hearing loss. Study Design and Methods. This observational cohort study includes a pure-tone audiometry of the patients who underwent chemotherapeutic treatment. Medical history, presence of risk factors for hearing loss, toxic habits, and association with haplogroups have been determined. Results. 40% of patients developed hearing loss after administration of cisplatin, which was bilateral and symmetrical and of high frequencies. The most frequent haplogroup was H with a slight overexpression of groups V and K and a low frequency of groups J and T. No association of the haplogroup types with the hearing loss has been found; however age was revealed as an important determining factor. Conclusions. Ototoxicity caused by cisplatin is manifested as bilateral, symmetrical, and predominantly high frequency hearing loss. Although we did not find a strong correlation of haplogroups with ototoxicity, our results revealed the existence of a risk group of elderly patients over 60, which are more susceptible to hearing loss induced by cisplatin, than young adults, regardless of preexisting hearing loss.
http://ift.tt/2sxeFtB
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Δευτέρα 3 Ιουλίου 2017
Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss
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- Metastatic sarcomatoid renal cell carcinoma manife...
- Ribosomal Chamber Music: Toward an Understanding o...
- Experimental Simulation of Clinical Borderline Sit...
- Investigation of Electrical Stimulation Levels Ove...
- A Comparison of Distortion Product Otoacoustic Emi...
- Regulation of the Immune System by Laminins
- Mucosal Bioengineering: Gut in a Dish
- Investigating pH based evaluation of fetal heart r...
- Development and application of a perioral force me...
- Treatment for the endocrine resistant breast cance...
- A regulatory role of androgen in ovarian steroidog...
- Innate function of house dust mite allergens: robu...
- Innate function of house dust mite allergens: robu...
- Innate function of house dust mite allergens: robu...
- Chemokine isoforms and processing in inflammation ...
- Assessment of obstructive sleep apnoea treatment s...
- Is oestrogen associated with mandibular condylar r...
- Impact of highly active antiretroviral therapy on ...
- Vitamin E Isoform γ-Tocotrienol Protects Against E...
- Inhibition of platelet-derived growth factor recep...
- Quantitative Analysis of Hepatic Microcirculation ...
- Alterations in nociception and morphine antinocice...
- Transabdominal Ultrasound Colonography for Detecti...
- Obese Heart Failure With Preserved Ejection Fracti...
- Long Noncoding RNA MANTIS Facilitates Endothelial ...
- Decoupling the effects of stiffness and fiber dens...
- Circulation Editors and Editorial Board.
- Grounding Cardio-Oncology in Basic and Clinical Sc...
- Evidence Supporting the Existence of a Distinct Ob...
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- Nitroglycerine and Angina: Evolving Clinical Coron...
- Association Between Fetal Congenital Heart Defects...
- Preeclampsia and Fetal Congenital Heart Defects: S...
- Effect of Long-Term Metformin and Lifestyle in the...
- Long Noncoding RNAs and Angiogenesis: Regulatory I...
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- Melanocortin 1 Receptor Signaling Regulates Choles...
- Is Cardioprotection Dead?.
- Breaking Meeting News: ACC.17
- Letter by Cerit Regarding Article, "Recurrent Hosp...
- Response by Gibson and Fox to Letter Regarding Art...
- Letter by Koh Regarding Article, "Factorial Effect...
- Response by Watts et al to Letter Regarding Articl...
- Flow cytometry-based diagnosis of primary immunode...
- Differential effect of the overexpression of Rad2/...
- Editorial: REM sleep behavior disorder and obstruc...
- Back to sleep- or not: The impact of the supine po...
- Secondary encephalocele in infant following subdur...
- Absence of Relationship between Mitochondrial DNA ...
- Characterization of gliomas: from morphology to mo...
- Service evaluation of patients’ views on the Patie...
- Absence of Relationship between Mitochondrial DNA ...
- “Archers lip”: a lesion on the upper lip
- Medialization Laryngoplasty After Injection Augmen...
- “Prologues to a Bad Voice”: Effect of Vocal Hygien...
- Sarcoidosis Presenting as Bilateral Vocal Fold Imm...
- Does a face-bow lead to better occlusion in comple...
- Oxidative potential of PM2.5 during Atlanta rush h...
- Time-resolved analysis of particle emissions from ...
- Particulate matter from re-suspended mineral dust ...
- The association between Mycoplasma pneumoniae infe...
- Topographical projections from the nucleus basalis...
- Unusual metallic penile foreign body
- An unusual case of KBG syndrome with unique oral f...
- Laryngeal lipoma: a rare cause of acute intermitte...
- Case of pneumatosis intestinalis and hepatic porta...
- Access to essential paediatric eye surgery in the ...
- Pulmonary co-infection with Nocardia and Aspergill...
- A rare presentation of multiple dens invaginatus i...
- Thoracic vertebral osteomyelitis: an unusual compl...
- Endodontic retreatment of a mandibular first molar...
- Cold finger: urban frostbite in the UK
- Central nervous system infection with Acanthamoeba...
- Herbicide/Zn-Al-layered double hydroxide hybrid co...
- Biosynthesis of staphylococcal enterotoxin A by ge...
- Preparation of modified waterworks sludge particle...
- The Effect of Attention-Deficit/Hyperactivity Diso...
- Effects of a Conversation-Based Intervention on th...
- Cluster-Randomized Controlled Trial Evaluating the...
- Assessing the Importance of Lexical Tone Contour t...
- Case History Risk Factors for Specific Language Im...
- Ecologically Valid Assessment of Prospective Memor...
- Cytokine storms in infectious diseases
- Towards predicting the encoding capability of MR f...
- Oral submucous fibrosis—an increasing global healt...
- Effects of the GaAlAs diode laser (780 nm) on the ...
- Curcumin photodynamic effect in the treatment of t...
- Abnormal renal parenchyma accumulation of 123I MIB...
- Differentiation of low- and high-grade clear cell ...
- Utility of surveillance MRI in women with a person...
- Evaluation of white matter hypodensities on comput...
- Adjuvant radiochemotherapy in locally advanced gas...
- Indoleamine 2,3-dioxygenase and Iron are required ...
- Calcium hydroxide associated with a new vehicle: P...
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