Publication date: October 2017
Source:Biomedicine & Pharmacotherapy, Volume 94
Author(s): Cheng Yang, Jie Gao, Banglin Wu, Nuo Yan, Hui Li, Yiqing Ren, Yufei Kan, Jiamin Liang, Yang Jiao, Yonghao Yu
We studied the effects of minocycline (an inhibitor of microglial activation) on the expression and activity of Notch-1 receptor, and explored the therapeutic efficacy of minocycline combined with Notch inhibitor DAPT in the treatment of diabetic neuropathic pain (DNP). Diabetic rat model was established by intraperitoneal injection (ip) of Streptozotocin (STZ). Expression and activity of Notch-1 and expression of macrophage/microglia marker Iba-1 were detected by WB. Diabetes induction significantly attenuated sciatic nerve conduction velocity, and dramatically augmented the expression and the activity of Notch-1 in the lumbar enlargement of the spinal cord. Minocycline treatment, however, accelerated the decreased conduction velocity of sciatic nerve and suppressed Notch-1expression and activity in diabetic rats. Similar to DAPT treatment, minocycline administration also prolonged thermal withdrawal latency (TWL) and increase mechanical withdrawal threshold (MWT) in diabetic rats in response to heat or mechanical stimulation via inhibition the expression and the activity of Notch-1 in spinal cord. Combination of DAPT and minocycline further inhibited Notch-1 receptor signaling and reduce neuropathic pain exhibited as improved TWL and MWT. Our study revealed a novel mechanism of Notch-1 receptor inhibition in spinal cord induced by minocycline administration, and suggested that the combination of minocycline and DAPT has the potential to treat DNP.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Τρίτη 1 Αυγούστου 2017
Minocycline attenuates the development of diabetic neuropathy by inhibiting spinal cord Notch signaling in rat
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- Multi year aerosol characterization in the tropica...
- Urban air pollution and health risks of parent and...
- Neural Evidence for Non-conscious Working Memory
- Transcription Factors Sp8 and Sp9 Coordinately Reg...
- Efficacy of a novel swallowing exercise program fo...
- Symptom burden and patient characteristics: Associ...
- Efficacy of a novel swallowing exercise program fo...
- Symptom burden and patient characteristics: Associ...
- The Mediator Complex: At the Nexus of RNA Polymera...
- College student with actigraphy performed during f...
- Sleep Phenotypes in Infants and Toddlers with Neur...
- Reduced P300 amplitude during a visuospatial atten...
- Correlation Between the Epworth Sleepiness Scale a...
- Relapse insomnia increases greater risk of anxiety...
- A preliminary examination of gut microbiota, sleep...
- A comparison of the tongue-in-groove and columella...
- CONTENTS 1
- CONTENTS 2
- Cytological and histological changes in the urothe...
- Thyroid Transcription Factor-1 promotes lymph node...
- Exploration of the pathways and interaction networ...
- Evaluation of expression of genes CADM1, TWIST1 an...
- Optical Loupes: A Useful Tool for the Oncall Otorh...
- Optical Loupes: A Useful Tool for the Oncall Otorh...
- Botulinum Toxin Injections Into the Lateral Cricoa...
- Optical Loupes: A Useful Tool for the Oncall Otorh...
- Optical Loupes: A Useful Tool for the Oncall Otorh...
- The impact of onabotulinumtoxinA on severe headach...
- Evaluation of the budding and depth of invasion (B...
- Desensitization to a whole egg by rush oral immuno...
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- Biology and management of Avena fatua and Avena lu...
- Is myometrial inflammation a cause or a consequenc...
- Anti-inflammatory effects of exercise training in ...
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- Zika virus infection as a trigger of atopic dermat...
- Increased malignancy incidence in IgE deficient pa...
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- Development and application of a novel fluorescent...
- Integrating fluorescent molecularly imprinted poly...
- Mkit: A cell migration assay based on microfluidic...
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- Dendritic cell recruitment and activation in autoi...
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- Burning Fat and Building Bone by FSH Blockade
- What’s So Special about FGF19—Unique Effects Repor...
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