Participation of cyclooxigenase-2 in lip carcinogenesis

Abstract

Inflammation is recognized as one of the earliest events of carcinogenesis. In the tumor microenvironment, cyclooxygenases (COX) act as mediators of the inflammatory pathomechanisms. COX-2 plays a role in the tumorigenic process through stimulation of cell proliferation, angiogenesis, inhibition of apoptosis, and modification of cell adhesion molecules.^1,2 Despite its well-explored function in ultraviolet (UV)-induced skin cancer, little is known about COX-2 influence on lip carcinogenesis.

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