Publication date: Available online 31 July 2017
Source:Vaccine
Author(s): G.A. Poland, I.G. Ovsyannikova, R.B. Kennedy
At the current time, the field of vaccinology remains empirical in many respects. Vaccine development, vaccine immunogenicity, and vaccine efficacy have, for the most part, historically been driven by an empiric "isolate-inactivate-inject" paradigm. In turn, a population-level public health paradigm of "the same dose for everyone for every disease" model has been the normative thinking in regard to prevention of vaccine-preventable infectious diseases. In addition, up until recently, no vaccines had been designed specifically to overcome the immunosenescence of aging, consistent with a post-WWII mentality of developing vaccines and vaccine programs for children. It is now recognized that the current lack of knowledge concerning how immune responses to vaccines are generated is a critical barrier to understanding poor vaccine responses in the elderly and in immunoimmaturity, discovery of new correlates of vaccine immunogenicity (vaccine response biomarkers), and a directed approach to new vaccine development.The new fields of vaccinomics and adversomics provide models that permit global profiling of the innate, humoral, and cellular immune responses integrated at a systems biology level. This has advanced the science beyond that of reductionist scientific approaches by revealing novel interactions between and within the immune system and other biological systems (beyond transcriptional level), which are critical to developing "downstream" adaptive humoral and cellular responses to infectious pathogens and vaccines. Others have applied systems level approaches to the study of antibody responses (a.k.a. "systems serology"), [1] high-dimensional cell subset immunophenotyping through CyTOF, [2,3] and vaccine induced metabolic changes [4]. In turn, this knowledge is being utilized to better understand the following: identifying who is at risk for which infections; the level of risk that exists regarding poor immunogenicity and/or serious adverse events; and the type or dose of vaccine needed to fully protect an individual. In toto, such approaches allow for a personalized approach to the practice of vaccinology, analogous to the substantial inroads that individualized medicine is playing in other fields of human health and medicine. Herein we briefly review the field of vaccinomics, adversomics, and personalized vaccinology.
http://ift.tt/2vf032O
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- SCIAMACHY observed changes in the column mixing ra...
- Multi year aerosol characterization in the tropica...
- Urban air pollution and health risks of parent and...
- Neural Evidence for Non-conscious Working Memory
- Transcription Factors Sp8 and Sp9 Coordinately Reg...
- Efficacy of a novel swallowing exercise program fo...
- Symptom burden and patient characteristics: Associ...
- Efficacy of a novel swallowing exercise program fo...
- Symptom burden and patient characteristics: Associ...
- The Mediator Complex: At the Nexus of RNA Polymera...
- College student with actigraphy performed during f...
- Sleep Phenotypes in Infants and Toddlers with Neur...
- Reduced P300 amplitude during a visuospatial atten...
- Correlation Between the Epworth Sleepiness Scale a...
- Relapse insomnia increases greater risk of anxiety...
- A preliminary examination of gut microbiota, sleep...
- A comparison of the tongue-in-groove and columella...
- CONTENTS 1
- CONTENTS 2
- Cytological and histological changes in the urothe...
- Thyroid Transcription Factor-1 promotes lymph node...
- Exploration of the pathways and interaction networ...
- Evaluation of expression of genes CADM1, TWIST1 an...
- Optical Loupes: A Useful Tool for the Oncall Otorh...
- Optical Loupes: A Useful Tool for the Oncall Otorh...
- Botulinum Toxin Injections Into the Lateral Cricoa...
- Optical Loupes: A Useful Tool for the Oncall Otorh...
- Optical Loupes: A Useful Tool for the Oncall Otorh...
- The impact of onabotulinumtoxinA on severe headach...
- Evaluation of the budding and depth of invasion (B...
- Desensitization to a whole egg by rush oral immuno...
- Cordyceps Sinensis: Anti-fibrotic and inflammatory...
- Biology and management of Avena fatua and Avena lu...
- Is myometrial inflammation a cause or a consequenc...
- Anti-inflammatory effects of exercise training in ...
- Lead-free (Ba,Ca)(Ti,Zr)O3 ceramics within the pol...
- Manufacturing of FeCoCrNiCux medium-entropy alloy ...
- Enhanced strength and ductility of bulk CoCrFeMnNi...
- Duplex stainless steel fabricated by selective las...
- Analyses of a Mutant Foxp3 Allele Reveal BATF as a...
- An antigen-specific semi-therapeutic treatment wit...
- Non-proinflammatory and responsive nanoplatforms f...
- Advance Directives, Hospitalization, and Survival ...
- A Phase II Study with Lead‐In Safety Cohort of 5‐F...
- Comparative efficacy of pharmacological and non-ph...
- Daphnoretin modulates differentiation and maturati...
- Inside front cover
- Naturally occurring immunomodulators with antitumo...
- Characterization and evaluation of nanoencapsulate...
- Reevaluating the Sensory Account of Visual Working...
- Retropharyngeal abscess as a result of hyaluronic ...
- Histopathology of tympanic membranes from patients...
- Tmj total reconstruction with stock and custom mad...
- Vitiligo: Mechanistic Insights Lead to Novel Treat...
- Expansion of cytotoxic CD56bright NK cells during ...
- Expansion of cytotoxic CD56bright NK cells during ...
- Vitiligo: Mechanistic Insights Lead to Novel Treat...
- Retropharyngeal abscess as a result of hyaluronic ...
- Retropharyngeal abscess as a result of hyaluronic ...
- Increasing positive attitudes toward individuals w...
- Increased malignancy incidence in IgE deficient pa...
- Hypogammaglobulinemia E in 216 adults with IgG sub...
- Zika virus infection as a trigger of atopic dermat...
- Increased malignancy incidence in IgE deficient pa...
- Bronchial thermoplasty induces immunomodulation wi...
- Zika virus infection as a trigger of atopic dermat...
- Guidelines for Drinking-Water Quality: Fourth Edit...
- Interventions to Prevent Age-Related Cognitive Dec...
- The black rock series supported SCR catalyst for N...
- PRP Popular for Alopecia Despite Lack of Robust Ev...
- Determinants of Implementation of Isolation Precau...
- Reflector-guided breast tumor localization versus ...
- Screening performance for callosal agenesis in pre...
- Vaginal tumor–vesical fistula detected by dynamic ...
- Pt-decorated zinc oxide nanorod arrays with graphi...
- Perpendicular magnetic anisotropy in ZnMnS ultra-t...
- Anticancer Agents; +345 new citations
- Arthroconidia in Lung Tissue: An Unusual Histopath...
- Bilateral pheochromocytoma with ganglioneuroma com...
- Impedance cardiography in healthy children and chi...
- Executive Functions Impact the Relation Between Re...
- Noise Equally Degrades Central Auditory Processing...
- Carbon dots based photoelectrochemical sensors for...
- Development and application of a novel fluorescent...
- Integrating fluorescent molecularly imprinted poly...
- Mkit: A cell migration assay based on microfluidic...
- The Role of Simulation in Microsurgical Training
- Neurogenic Orofacial Weakness and Speech in Adults...
- In vitro genotoxicity of asbestos substitutes indu...
- Chemical properties of dissolved organic matter de...
- Expression of intelectin-1 in bronchial epithelial...
- Expression of intelectin-1 in bronchial epithelial...
- Bilateral pheochromocytoma with ganglioneuroma com...
- Dendritic cell recruitment and activation in autoi...
- Holding Onto Youth
- Burning Fat and Building Bone by FSH Blockade
- What’s So Special about FGF19—Unique Effects Repor...
- Once Blind, Now We See GLP-1 Molecular Action
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