Publication date: Available online 18 October 2017
Source:Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Author(s): Junjie Zhou, Ruiyu Wang, Jing Zhang, Liyuan Zhu, Wei Liu, Shuaiyao Lu, Pan Chen, Hanlu Li, Bin Yin, Jiangang Yuan, Boqin Qiang, Pengcheng Shu, Xiaozhong Peng
T-UCRs, a class of long non-coding RNAs that are transcribed from ultra-conserved regions (UCRs), might play an important role in development and diseases. However, the amount of T-UCRs that are conservatively expressed in the developing nervous systems of mice, monkeys and humans is still unknown. In this study, we screened the RNA sequence signals of 481 identified UCRs in an E14.5 mouse brain from the ENCODE database and found 76 UCRs that may be transcribed into T-UCRs. To verify the expression of these potential T-UCRs, we used an RT-PCR experiment and identified that 60 T-UCRs can be expressed in the E14.5 mouse brain. Furthermore, we detected the expression conservation of 76 potential T-UCRs in two comparisons: postnatal day 0 brains of a mouse and a rhesus monkey and neural stem cell of mouse and human by RT-PCR experimentation. It was found that up to 65% of these T-UCRs were expressed in mouse, rhesus monkey and human nervous systems. Next, by testing the spatiotemporal expression pattern of these T-UCRs expressed in mouse, rhesus monkey and human nervous systems, we found that approximately 30% of the T-UCRs showed a relatively high and dynamical expression during mouse brain development. Finally, through biological process and molecular function gene ontology analysis of the host genes of intronic or exonic-antisense T-UCRs, it was discovered that most of the genes were involved in RNA splicing or RNA binding. These results suggest that T-UCRs are likely to participate in nervous system development through RNA processing.
http://ift.tt/2xQGL0F
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Πέμπτη 19 Οκτωβρίου 2017
Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system
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- High adherence to subcutaneous immunotherapy in a ...
- Hereditary angioneurotic edema … a disease has bee...
- Interleukin 31 and skin diseases: A systematic review
- Management of adverse reactions to biologic agents
- Evaluation of beclomethasone dipropionate (80 and ...
- Indicators of poorly controlled asthma and health-...
- Health-related quality of life in Danish children ...
- Health-related quality of life in relation to dise...
- Efficacy of recombinant human C1 esterase inhibito...
- Recombinant human C1 esterase inhibitor for acute ...
- The role of intravenous access during oral food ch...
- For the Patient
- Association of imbalance of effector T cells and r...
- High adherence to subcutaneous immunotherapy in a ...
- Hereditary angioneurotic edema … a disease has bee...
- Interleukin 31 and skin diseases: A systematic review
- Management of adverse reactions to biologic agents
- Evaluation of beclomethasone dipropionate (80 and ...
- Indicators of poorly controlled asthma and health-...
- Health-related quality of life in Danish children ...
- Health-related quality of life in relation to dise...
- Efficacy of recombinant human C1 esterase inhibito...
- Recombinant human C1 esterase inhibitor for acute ...
- The role of intravenous access during oral food ch...
- For the Patient
- Graphical Abstracts
- Meet Our Editorial Board Member
- Recent Advances on the Role of Neurogenesis in the...
- The Role of Innate Immune System Receptors in Epil...
- Natural Steroids and Androgen Antagonists used as ...
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- Granulocyte Colony-Stimulating Factor Attenuates B...
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- Advanced Structure-activity Relationships Applied ...
- Lithium Restores Age-related Olfactory Impairment ...
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- The Positive Synergism of CPT and MK-801 in Behavi...
- Differential Mechanisms Underlying Antidepressant ...
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- A case of autosplenectomy associated with T-cell c...
- Non-infectious aortitis in an immunosuppressed ren...
- Learning from errors: unnecessary intensive care u...
- A case of tuberculous gumma: there is more to it t...
- Giant meningioma in skull radiograph
- Community-acquired Pseudomonas aeruginosa meningitis
- Result of Health Illiteracy and Cultural Stigma: F...
- Anaesthesia and orphan disease: airway and anaesth...
- Rare presentation of an old bug
- Management challenges of late presentation Dacron ...
- Unusual cause of saddle nose
- Gentamicin-vancomycin-colistin local antibiotherap...
- Primary hepatic hemangioendothelioma in a patient ...
- Amyands hernia detected incidentally in two patients
- Re-correction osteotomy with osteophyte graft for ...
- Honeycomb and necklace signs in liver abscesses se...
- Vancomycin-associated drug reaction with eosinophi...
- Memory of World War II with loud atypical friction...
- The migrant crisis comes to Minnesota: a dermatolo...
- Nano-scale precipitation and phase growth in Mg-Gd...
- Oxidation–nitridation-induced recrystallization in...
- Evaluation of novel temperature-stable viscoelasti...
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- Automated MicroSPECT/MicroCT Image Analysis of the...
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- Role of Krüppel-Like Factor 4 in the Maintenance o...
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- Review of "Setting Performance Standards for Techn...
- 13-93B3 Bioactive Glass: a New Scaffold for Transp...
- Hemodynamic Changes in Paramedian Forehead Flap.
- The Etiology of Neuronal Development in Craniosyno...
- Hydatid Cyst of the Parotid Gland: A Rare Location.
- Outcomes of Titanium Mesh Cranioplasty in Pediatri...
- Virtual Reality Model of the Three-Dimensional Ana...
- Skull Base Neuroendoscopic Training Model Using a ...
- A Modification to the Nasal Septal Chain Suture Wh...
- Metopism: a Study of the Persistent Metopic Suture.
- Distribution of Elastic Fibers in the Lacrimal Sac...
- Spontaneous Rupture of Lacrimal Gland Pleomorphic ...
- Statin Use and Breast Cancer Prognosis in Black an...
- First Clinical Consensus and National Recommendati...
- Impact of cartilage graft size on success of tympa...
- Encoding of speech sounds at auditory brainstem le...
- Profile and prevalence of hearing complaints in th...
- Preoperative vestibular assessment protocol of coc...
- Treatment of large persistent tracheoesophageal pe...
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