Publication date: July 2018
Source:Biomedicine & Pharmacotherapy, Volume 103
Author(s): Muhammad Abbas, Alessia Faggian, Dahiru Nasiru Sintali, Ghulam Jilany Khan, Shagufta Naeem, Meiqi Shi, Chen Dingding
Gastric cancer is the fourth most common worldwide cause of cancer-related death. Early gastric cancer has no associated symptoms, for this reason, patients come to the attention of the clinicians only in advanced stages. This paper aims to give a global view on the biomarkers for gastric cancer and the therapy in use. We discuss VEGF family, HER family, E-cadherin, PD-L1, and PD-L2, FGFR, mTOR. Finally, we considered emerging biomarkers as MET, microsatellite instability, and microRNA variations. Furthermore, we have analyzed in depth the chemotherapeutic and adjuvant therapies used in the clinic nowadays, comparing the overall and progression-free survival between them. Identifying and validating diagnostic, prognostic, predictive, and pharmacodynamic biomarkers will be mandatory to the huge impact on patients' outcomes and for improving the efficiency of the drug development process.
https://ift.tt/2jTsNGM
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Current and future biomarkers in gastric cancer
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- Global Health in Otolaryngology
- Otolaryngologic Clinics of North America
- Otolaryngology and the Global Burden of Disease
- Contents
- The Small World of Global Otolaryngology
- Copyright
- Regional Overview of Specific Populations, Workfor...
- Contributors
- Bed II Sequence Stratigraphic context of EF-HR and...
- Technological behaviour in the early Acheulean of ...
- Editorial Board
- Frank Brown (1943–2017)
- Patterns of lateral enamel growth in Homo naledi a...
- Mesopithecus pentelicus from the Turolian locality...
- Reevaluation of ‘endocostal ossifications’ on the ...
- The effect of ontogeny on estimates of KNM-WT 1500...
- A new tephrochronology for early diverse stone too...
- From the Oldowan to the Acheulean at Olduvai Gorge...
- Was the last common ancestor aping a chimp or just...
- Human-like hip joint loading in Australopithecus a...
- A biplanar X-ray approach for studying the 3D dyna...
- New hominin postcranial remains from locality OMO ...
- Large mammal diets and paleoecology across the Old...
- Reconstruction, endocranial form and taxonomic aff...
- Is there a Developed Oldowan A at Olduvai Gorge? A...
- The costs of living at the edge: Seasonal stress i...
- Mandibular ramus shape variation and ontogeny in H...
- Low or Undetectable Basal Thyroglobulin Levels Obv...
- An anti-NMDA receptor encephalitis mimicking an HI...
- Networked Individuals, Gendered Violence: A Litera...
- Editorial Board
- An anti-NMDA receptor encephalitis mimicking an HI...
- Total glossolaryngectomy cohort study (N = 25): Su...
- Aortic Stenosis: Then and Now.
- Natriuretic Peptide-Guided Heart Failure Therapy A...
- Impact of Bystander Automated External Defibrillat...
- Association Between Early Hyperoxia Exposure After...
- Oxygen After Cardiac Arrest: Enough Is Enough?.
- Accounting for Nonadherence.
- Complement Receptor C5aR1 Plays an Evolutionarily ...
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- Letter by Adabag et al Regarding Article, "Age and...
- Response by Elming et al to Letter Regarding Artic...
- Letter by Koshy et al Regarding Article, "Assessme...
- Response by Halcox and Wareham to Letter Regarding...
- Letter by Koh Regarding Article, "Day-to-Day Blood...
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- Effects of ceftriaxone-induced intestinal dysbacte...
- A systematic review on the frequency of BRCA promo...
- Micropatterned biodegradable polyesters clicked wi...
- Identifying and siding the stylohyoid bone for Nor...
- First evidence of elongated styloid process in two...
- VideoEndocrinology™ High-Impact Videos
- Issue Information
- VideoEndocrinology™ High-Impact Videos
- HippoCA3mpal Stem Cell Models Expose Dysfunctional...
- Patient-Derived iPSC-Hypothamic Neurons: The Ultim...
- Crinkle-Cut Brain Organoids
- The Lysosome, Elixir of Neural Stem Cell Youth
- Mentoring the Next Generation: Hongkui Deng
- Blood Development: Hematopoietic Stem Cell Depende...
- Efficient Generation of CA3 Neurons from Human Plu...
- Super-Obese Patient-Derived iPSC Hypothalamic Neur...
- Spred1 Safeguards Hematopoietic Homeostasis agains...
- PRC1 Fine-tunes Gene Repression and Activation to ...
- Retinoid-Sensitive Epigenetic Regulation of the Ho...
- The Dystrophin Glycoprotein Complex Regulates the ...
- Fasting Activates Fatty Acid Oxidation to Enhance ...
- Submucosal Gland Myoepithelial Cells Are Reserve S...
- Editorial Board
- Two cases of discrete adenoid pseudogland formatio...
- Disseminated Kaposi sarcoma with epithelioid morph...
- Oral juvenile xanthogranuloma in a child: Clinical...
- Bone fragility in Turner syndrome: Fracture preval...
- Building Blocks of Social Cognition: Mirror, Menta...
- The role of sentinel lymph node biopsy as a stagin...
- A ticking time bomb: A case of Lyme disease
- A rare case of chronic expanding haematoma in the ...
- Chemotherapy‐induced alopecia: A novel observation
- Noninvasive size reduction of lipoma with an insul...
- The role of sentinel lymph node biopsy as a stagin...
- Contact dermatitis to Dermabond Advance®
- A ticking time bomb: A case of Lyme disease
- Pancreatic panniculitis: A case series from a tert...
- A rare case of chronic expanding haematoma in the ...
- Chemotherapy‐induced alopecia: A novel observation
- Epinephrine, auto-injectors and anaphylaxis: chall...
- Angioedema: systemic activation process during pro...
- Aldolase: a new crustacea allergen
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