‘Et Tu, Leptin?’

Publication date: Available online 18 February 2019

Source: Trends in Endocrinology & Metabolism

Author(s): Diego Perez-Tilve

Leptin promotes adequate caloric intake and glycemia in healthy lean individuals, harnessing the benefits of the ideal therapy against metabolic syndrome. Yet, new evidence demonstrates an unexpected causal role for leptin in obesity-associated hyperglycemia. Like the betrayal of Julius Caesar by Brutus, insulin did not see that coming from leptin.

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