Cardiac safety of systemic therapy in breast cancer patients with high risk of atherosclerosis complications.

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Cardiac safety of systemic therapy in breast cancer patients with high risk of atherosclerosis complications.

Future Oncol. 2016 Oct 27;

Authors: Matyszewski A, Czarnecka AM, Stachowiak P, Nowakowska M, Kornacewicz-Jach Z, Kasprzak JD, Szczylik C

Abstract
AIM: This study was designed to verify the efficacy of breast cancer treatment and its cardiac toxicity in population with significant cardiac comorbidities.
MATERIALS & METHODS: Prospective observational study was conducted in 48 patients.
RESULTS: The increase and dependence of echocardiographic parameter early/late were observed on hemoglobin level in all patients, and white blood cells and cholesterol in patients with diabetic were reported. Patients undergo left ventricle diameter change on treatment.
CONCLUSION: Use of potentially cardiotoxic chemo regimens in breast cancer patients with cardiac comorbidities, with optimized cardiac therapy accordingly can save patients from development of early myocardial dysfunction induced by chemotherapy - limiting factor to minimize the risk is optimization of lipid level, red blood cell count and platelets count.

PMID: 27784174 [PubMed - as supplied by publisher]

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