Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma.

Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma.

Oncotarget. 2016 Oct 25;:

Authors: Wang SS, Cen X, Liang XH, Tang YL

Abstract
Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, has been showed to be associated with the immunopathogenesis of many diseases. Recent study demonstrated that MIF promoted tumorigenesis and tumor progression and played a critical role in various kinds of human cancer including head and neck squamous cell carcinoma(HNSCC). Hence, in this paper we retrospected the relationship between MIF and angiogenesis, epithelial-mesenchymal transition (EMT), inflammation, immune response, hypoxia microenvironment, and discussed whether it is a promising biomarker for diagnosis and supervisor of HNSCC.

PMID: 27788497 [PubMed - as supplied by publisher]

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