Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

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Δευτέρα 13 Ιουλίου 2020


Primary melanotic tumors of the nervous system: a consecutive case series.
Related Articles Primary melanotic tumors of the nervous system: a consecutive case series. Eur J Neurol. 2020 Jul 12;: Authors: Grosshans HK, Huttner AJ, Piepmeier JM, Kaulen LD, Fulbright RK, Baehring JM, Karschnia P Abstract BACKGROUND: Primary melanotic tumors of the nervous system (PMTNS) are thought to be an exceedingly rare group of tumors not captured by tumor registries. We aimed to determine relative incidence, clinical presentation,...
Rare Cancers
Mon Jul 13, 2020 14:38
Primary Merkel Cell Carcinoma: A Retrospective Analysis of 31 Cases in Poland.
Related Articles Primary Merkel Cell Carcinoma: A Retrospective Analysis of 31 Cases in Poland. Dermatol Ther (Heidelb). 2020 Jul 11;: Authors: Ciążyńska M, Szczepaniak K, Pabianek M, Nejc D, Reich A, Ułańska M, Owczarek W, Skibińska M, Narbutt J, Lesiak A Abstract INTRODUCTION: Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine cancer that typically arises in sun-exposed areas of the skin, especially in the elderly....
Rare Cancers
Mon Jul 13, 2020 14:38
Basal ganglia calcification in hypoparathyroidism and pseudohypoparathyroidism: local and systemic metabolic mechanisms
Abstract Background Hypoparathyroidism and pseudohypoparathyroidism are rare disorders of mineral metabolism which may be associated with soft tissue calcification in the basal ganglia in the brain, and occasionally the skin and other tissues. The basal ganglia are the most common sites of calcification in the central nervous system in these disorders, and were first associated with this manifestation in a report from the Mayo Clinic in...
Journal of Endocrinological Investigation
Mon Jul 13, 2020 03:00
Addressing male sexual and reproductive health in the wake of COVID-19 outbreak
Abstract Purpose The COVID-19 pandemic, caused by the SARS-CoV-2, represents an unprecedented challenge for healthcare. COVID-19 features a state of hyperinflammation resulting in a “cytokine storm”, which leads to severe complications, such as the development of micro-thrombosis and disseminated intravascular coagulation (DIC). Despite isolation measures, the number of affected patients is growing daily: as of June 12th, over 7.5 million...
Journal of Endocrinological Investigation
Mon Jul 13, 2020 03:00
Does oral dryness influence pressure pain sensitivity in the oral mucosa of removable denture wearers?
Abstract Objective This study aimed to determine if oral dryness is associated with oral pain sensitivity in removable denture wearers. Materials and methods The pressure pain threshold (PPT) in the mucosa at the midline between the central incisors in the maxilla and mandible was evaluated in 333 removable denture wearers (mean age 71.2 years,...
Clinical Oral Investigations
Mon Jul 13, 2020 13:31
Is it safe to drive after oral surgery?
Abstract Objectives Driving ability largely depends on the total brake response time (TBRT) corresponding to the time a subject needs to react to a stimulus and apply a well-defined force on the brake pedal. As yet, the English literature completely lacks clinical studies evaluating the TBRT following oral surgery. Materials and methods In this...
Clinical Oral Investigations
Mon Jul 13, 2020 13:31
Association between periodontitis and glycosylated haemoglobin before diabetes onset: a cross-sectional study
Abstract Objectives The aim of the present cross-sectional study was to investigate the association between serum glycosylated haemoglobin (HbA1c) levels and periodontal status in patients with periodontitis (CP) and periodontally healthy controls. Furthermore, the objectives were to determine if the periodontitis influenced the serum HbA1c levels. Materials and methods...
Clinical Oral Investigations
Mon Jul 13, 2020 13:31
Pretreatment body mass index as a prognostic predictor in patients with oral squamous cell carcinoma
Abstract Objectives To evaluate whether low body mass index (BMI) is a potential adverse prognostic factor in patients with oral squamous cell carcinoma (OSCC). Material and methods This cross-sectional study included 320 patients with OSCC who underwent therapeutic surgical treatment in Taiwan. The pretreatment BMI was measured as a common...
Clinical Oral Investigations
Mon Jul 13, 2020 13:31
Guanylate-binding protein 6 is a novel biomarker for tumorigenesis and prognosis in tongue squamous cell carcinoma
Abstract Objectives Guanylate-binding protein 6 (GBP6) is a member of the guanylate-binding protein family, and its role in cancer has not yet been reported. We aimed to investigate the clinical significance of GBP6 in oral squamous cell carcinoma (OSCC). Materials and methods Next-generation sequencing was applied for analyzing differential...
Clinical Oral Investigations
Mon Jul 13, 2020 13:31
Management of anticoagulated patients in dentoalveolar surgery: a clinical comparative study
Abstract Objectives This prospective, comparative, clinical study analyzed the postoperative bleeding risk of patients on anticoagulation therapy (AT) who were undergoing tooth extractions and osteotomies. Materials and methods Patients with the following ATs were included (test groups): (1.) platelet aggregation inhibitors (PAIs), (2.) vitamin...
Clinical Oral Investigations
Mon Jul 13, 2020 13:31
In vitro and in silico evaluations of resin-based dental restorative material toxicity
Abstract Objectives This study aims to evaluate the cytocompatibility of three provisional restoration materials and predict neurotoxic potential of their monomers. These materials are Tab 2000® (methyl methacrylate based), ProTemp 4™ (bis-acrylic based) and Structur 3® (urethane dimethacrylate based). Materials and methods Resin samples were...
Clinical Oral Investigations
Mon Jul 13, 2020 13:31
Assessment of condylar volume and ramus height in JIA patients with unilateral and bilateral TMJ involvement: retrospective case-control study
Abstract Objectives The objectives of the study are to analyze volumetric differences of condylar volumes in patients with unilateral and bilateral JIA and to compare results with control condylar volumes. Materials and methods Forty-six CBCT images were analyzed for all patients affected by JIA, 37 females and 9 males (mean age 10.8 ± 4.2)...
Clinical Oral Investigations
Mon Jul 13, 2020 13:31
Validity and reproducibility of the 3D VECTRA photogrammetric surface imaging system for the maxillofacial anthropometric measurement on cleft patients
Abstract Objectives To validate the accuracy and reproducibility of linear measurements of three-dimensional (3D) images and to compare the measurements with the direct anthropometry method on cleft lip and palate (CLP) patients. Materials and methods Nineteen linear facial measurements were derived from 16 standardized surface landmarks obtained...
Clinical Oral Investigations
Mon Jul 13, 2020 13:31
Use of platelet-rich fibrin for the treatment of gingival recessions: a systematic review and meta-analysis
Abstract Objectives The aim of this systematic review and meta-analysis was to compare the use of platelet-rich fibrin (PRF) with other commonly utilized treatment modalities for root coverage procedures. Materials and methods The eligibility criteria comprised randomized controlled trials (RCTs) comparing the performance of PRF with that of...
Clinical Oral Investigations
Mon Jul 13, 2020 13:31
Comparison of dentin bond durability of a universal adhesive and two etch-and-rinse adhesive systems
Abstract Objective This study aimed to compare dentin bond durability under different degradation conditions between two etch-and-rinse (ER) systems and a universal adhesive in ER mode. Method This study used a universal adhesive [Scotchbond Universal (SU)], a three-step ER adhesive [Scotchbond Multi-Purpose Plus (SM)], and a two-step ER adhesive...
Clinical Oral Investigations
Mon Jul 13, 2020 13:31
How many third molars remain unnoticed in a population survey without panoramic radiographs?
Abstract Objective The aim of the study was to compare the findings of clinical examination and panoramic radiograph regarding the occurrence of third molars in a population survey to find out how many third molars remain clinically unnoticed. Materials and methods A two-staged stratified cluster-sampling method was used to select 8028 participants...
Clinical Oral Investigations
Mon Jul 13, 2020 13:31
Consultant‐delivered care in telehealth and phone consultations during the COVID‐19 shutdown period
ANZ Journal of Surgery
Sun Jul 12, 2020 21:14
Does COVID-19 influence sexual behaviours?
Related Articles Does COVID-19 influence sexual behaviours? Dermatol Ther. 2020 Jul 11;:e14004 Authors: Gaspari V, Orioni G, Viviani F, Raone B, Lanzoni A, Bardazzi F PMID: 32654248 [PubMed - as supplied by publisher]
Head and Neck
Mon Jul 13, 2020 14:27
Completion lymph node dissection in patients with sentinel lymph node positive cutaneous head and neck melanoma.
Related Articles Completion lymph node dissection in patients with sentinel lymph node positive cutaneous head and neck melanoma. J Surg Oncol. 2020 Jul 11;: Authors: Huang K, Misra S, Lemini R, Chen Y, Speicher LL, Dawson NL, Tolaymat LM, Bagaria SP, Gabriel EM Abstract BACKGROUND: Relatively few cutaneous head and neck melanoma (CHNM) patients with were included in the multicenter selective lymphadenectomy trial II (MSLT-II). Our objective...
Head and Neck
Mon Jul 13, 2020 14:27
Comparison of CBCT-based dose calculation methods in head and neck cancer radiotherapy: from Hounsfield unit to density calibration curve to deep learning.
Related Articles Comparison of CBCT-based dose calculation methods in head and neck cancer radiotherapy: from Hounsfield unit to density calibration curve to deep learning. Med Phys. 2020 Jul 12;: Authors: Barateau A, De Crevoisier R, Largent A, Mylona E, Perichon N, Castelli J, Chajon E, Acosta O, Simon A, Nunes JC, Lafond C Abstract PURPOSE: Anatomical variations occur during head and neck (H&N) radiotherapy treatment. kV cone-beam...
Head and Neck
Mon Jul 13, 2020 14:27
Impact of insurance on hospital course and readmission after resection of benign meningioma.
Related Articles Impact of insurance on hospital course and readmission after resection of benign meningioma. J Neurooncol. 2020 Jul 11;: Authors: Hauser BM, Gupta S, Xu E, Wu K, Bernstock JD, Chua M, Khawaja AM, Smith TR, Dunn IF, Bergmark RW, Bi WL Abstract INTRODUCTION: Surgical outcomes and healthcare utilization have been shown to vary based on patient insurance status. We analyzed whether patients' insurance affects case urgency for...
Head and Neck
Mon Jul 13, 2020 14:27
The DizzyQuest: to have or not to have… a vertigo attack?
Related Articles The DizzyQuest: to have or not to have… a vertigo attack? J Neurol. 2020 Jul 11;: Authors: de Joode LEGH, Martin EC, Stultiens JJA, Leue C, Delespaul P, Peeters F, Erdkamp A, van de Weijer S, Blom H, Bruintjes T, Zwergal A, Grill E, Guinand N, Perez-Fornos A, van de Berg MR, Widdershoven J, Kingma H, van de Berg R Abstract BACKGROUND: The DizzyQuest, an app-based vestibular diary, provides the opportunity to capture the...
Head and Neck
Mon Jul 13, 2020 14:27
Dysphagia Care Across the Continuum: A Multidisciplinary Dysphagia Research Society Taskforce Report of Service-Delivery During the COVID-19 Global Pandemic.
Related Articles Dysphagia Care Across the Continuum: A Multidisciplinary Dysphagia Research Society Taskforce Report of Service-Delivery During the COVID-19 Global Pandemic. Dysphagia. 2020 Jul 11;: Authors: Miles A, Connor NP, Desai RV, Jadcherla S, Allen J, Brodsky M, Garand KL, Malandraki GA, McCulloch TM, Moss M, Murray J, Pulia M, Riquelme LF, Langmore SE Abstract At the time of writing this paper, there are over 11 million reported...
Head and Neck
Mon Jul 13, 2020 14:27
Facial nerve monitoring during parotid gland surgery: a systematic review and meta-analysis.
Related Articles Facial nerve monitoring during parotid gland surgery: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol. 2020 Jul 11;: Authors: Chiesa-Estomba CM, Larruscain-Sarasola E, Lechien JR, Mouawad F, Calvo-Henriquez C, Diom ES, Ramirez A, Ayad T Abstract INTRODUCTION: Facial nerve injury remains the most severe complication of parotid gland surgery. However, the use of intraoperative facial nerve monitoring (IFNM)...
Head and Neck
Mon Jul 13, 2020 14:27
Two different therapies for the middle turbinate during endoscopic sinus surgery for chronic rhinosinusitis.
Related Articles Two different therapies for the middle turbinate during endoscopic sinus surgery for chronic rhinosinusitis. Eur Arch Otorhinolaryngol. 2020 Jul 11;: Authors: Zhu M, Yan Y, Gong H, Wu Y, Tan G Abstract BACKGROUND: The population of patients with chronic rhinosinusitis (CRS) has greatly increased. When medical treatment fails, endoscopic sinus surgery (ESS) is considered. In the present study, the value of two different...
Head and Neck
Mon Jul 13, 2020 14:27
Systematic Review of Quality of Life Assessments after Cochlear Implantation in Older Adults.
Related Articles Systematic Review of Quality of Life Assessments after Cochlear Implantation in Older Adults. Audiol Neurootol. 2020 Jul 10;:1-15 Authors: Andries E, Gilles A, Topsakal V, Vanderveken OM, Van de Heyning P, Van Rompaey V, Mertens G Abstract Cochlear implants (CI) have increasingly been adopted in older adults with severe to profound sensorineural hearing loss as a result of the growing and aging world population. Consequently,...
Head and Neck
Mon Jul 13, 2020 14:27
Assessment of tumour depth in early tongue cancer: Accuracy of MRI and intraoral ultrasound.
Related Articles Assessment of tumour depth in early tongue cancer: Accuracy of MRI and intraoral ultrasound. Oral Oncol. 2020 Jul 09;110:104895 Authors: Noorlag R, Klein Nulent TJW, Delwel VEJ, Pameijer FA, Willems SM, de Bree R, van Es RJJ Abstract OBJECTIVES: Complete resection of tongue cancer is necessary to achieve local control. Unfortunately, deep resection margins are frequently inadequate. To improve deep margin control, accurate...
Head and Neck
Mon Jul 13, 2020 14:27
The landscape of new drugs in extranodal NK/T-cell lymphoma.
Related Articles The landscape of new drugs in extranodal NK/T-cell lymphoma. Cancer Treat Rev. 2020 Jul 02;89:102065 Authors: Wang L, Li LR, Zhang L, Wang JW Abstract To date, much progress has been made in early-stage extranodal NK/T-cell lymphoma (ENKTCL), and risk-adapted therapy with radiotherapy (RT) alone for the low-risk group and RT combined with asparaginase-based chemotherapy (CT) for the high-risk group yields favorable outcomes....
Head and Neck
Mon Jul 13, 2020 14:27
Recognizing odontogenic sinusitis: A national survey of otolaryngology chief residents.
Related Articles Recognizing odontogenic sinusitis: A national survey of otolaryngology chief residents. Am J Otolaryngol. 2020 Jul 04;41(6):102635 Authors: Shukairy MK, Burmeister C, Ko AB, Craig JR Abstract PURPOSE: Odontogenic sinusitis is underrepresented in sinusitis literature as well as in the otolaryngology teaching curriculum sponsored by the American Academy of Otolaryngology-Head and Neck Surgery. Otolaryngologists and residents...
Head and Neck
Mon Jul 13, 2020 14:27
Clinicoradiologic predictors of sclerotherapy response in low-flow vascular malformations.
Related Articles Clinicoradiologic predictors of sclerotherapy response in low-flow vascular malformations. J Vasc Surg Venous Lymphat Disord. 2020 Jul 08;: Authors: Bagga B, Goyal A, Das A, Bhalla AS, Kandasamy D, Singhal M, Kairo A Abstract OBJECTIVE: To evaluate the clinical effectiveness of sclerotherapy agents in low-flow-vascular malformations (LFVM) and identify clinical/imaging features to predict response. METHODS: A...
Head and Neck
Mon Jul 13, 2020 14:27
Factors Affecting Volume Change of Anterolateral Thigh Flap in Head and Neck Defect Reconstruction.
Related Articles Factors Affecting Volume Change of Anterolateral Thigh Flap in Head and Neck Defect Reconstruction. J Oral Maxillofac Surg. 2020 Jun 15;: Authors: Wang SJ, Zhang WB, Yu Y, Wang T, Yang HY, Peng X Abstract PURPOSE: The anterolateral thigh flap (ALTF) volume will decrease over time after surgery. We measured and identified the risk factors for postoperative volume changes in the ALTF. MATERIALS AND METHODS: We designed...
Head and Neck
Mon Jul 13, 2020 14:27
Automated Relative Fundamental Frequency Algorithms for Use With Neck-Surface Accelerometer Signals.
Related Articles Automated Relative Fundamental Frequency Algorithms for Use With Neck-Surface Accelerometer Signals. J Voice. 2020 Jul 08;: Authors: Groll MD, Vojtech JM, Hablani S, Mehta DD, Buckley DP, Noordzij JP, Stepp CE Abstract OBJECTIVE: Relative fundamental frequency (RFF) has been suggested as a potential acoustic measure of vocal effort. However, current clinical standards for RFF measures require time-consuming manual markings....
Head and Neck
Mon Jul 13, 2020 14:27
Long-term treatment of Japanese cedar pollinosis with Japanese cedar pollen SLIT drops and persistence of treatment effect: A post-marketing clinical trial.
Related Articles Long-term treatment of Japanese cedar pollinosis with Japanese cedar pollen SLIT drops and persistence of treatment effect: A post-marketing clinical trial. Allergol Int. 2020 Jul 08;: Authors: Nomura Y, Okubo K, Nakamura T, Sawaki S, Kitagou H, Idei N, Kaneko S, Kobayashi S, Tanaka Y, Okamoto Y Abstract BACKGROUND: There have been no reports of treatment effect persistence after long-term sublingual immunotherapy (SLIT)...
Head and Neck
Mon Jul 13, 2020 14:27
Epidemiologic relationship between periodontitis and type 2 diabetes mellitus.
Related Articles Epidemiologic relationship between periodontitis and type 2 diabetes mellitus. BMC Oral Health. 2020 Jul 11;20(1):204 Authors: Wu CZ, Yuan YH, Liu HH, Li SS, Zhang BW, Chen W, An ZJ, Chen SY, Wu YZ, Han B, Li CJ, Li LJ Abstract BACKGROUND: To systematically review the epidemiologic relationship between periodontitis and type 2 diabetes mellitus (T2DM). METHODS: Four electronic databases were searched up until...
Head and Neck
Mon Jul 13, 2020 14:27
Metformin and insulin treatment of gestational diabetes: effects on inflammatory markers and IGF-binding protein-1 - secondary analysis of a randomized controlled trial.
Related Articles Metformin and insulin treatment of gestational diabetes: effects on inflammatory markers and IGF-binding protein-1 - secondary analysis of a randomized controlled trial. BMC Pregnancy Childbirth. 2020 Jul 11;20(1):401 Authors: Huhtala MS, Tertti K, Juhila J, Sorsa T, Rönnemaa T Abstract BACKGROUND: Gestational diabetes mellitus (GDM) is characterized by disturbed glucose metabolism and activation of low-grade inflammation....
Head and Neck
Mon Jul 13, 2020 14:27
FDG-PET/CT Radiomics Models for The Early Prediction of Loco-regional Recurrence in Head and Neck Cancer.
Related Articles FDG-PET/CT Radiomics Models for The Early Prediction of Loco-regional Recurrence in Head and Neck Cancer. Curr Med Imaging. 2020 Jul 12;: Authors: Cong H, Peng W, Tian Z, Vallières M, Chuanpei X, Aijun Z, Benxin Z Abstract Purpose Both CT and PET radiomics is considered as a potential prognostic biomarker in head and neck cancer. This study investigate the value of fused pre-treatment functional imaging (18F-FDG PET/CT)...
Head and Neck
Mon Jul 13, 2020 14:27
Odontogenic tumors: an 11‐year international multicenter study
Abstract Odontogenic tumors (OTs) are a heterogeneous group of lesions originating from the remnants of the tooth‐forming apparatus (Nalabolu et al., 2016). The frequency rates of OTs vary from about 1% to 32% of all jawbone tumors (Adebayo et al., 2005; Sekerci et al., 2015).
Oral Diseases
Mon Jul 13, 2020 13:13
Function of gold nanoparticles in oral cancer beyond drug delivery: implications in cell apoptosis
Abstract Objectives Gold nanoparticles (AuNPs) are used to deliver drugs and therapeutic small molecule inhibitors to cancer cells. Evidence shows that AuNPs coated with nuclear localization sequence can cross the nuclear membrane and induce cellular apoptosis. To determine the therapeutic role of AuNPs, we compared two nanoconstructs conjugated to doxorubicin (DOX) through pH‐sensitive and pH‐resistant linkers. Materials and Methods We tested DOX‐nanoconjugates' cytotoxicity, cellular...
Oral Diseases
Mon Jul 13, 2020 12:51
Oral manifestations related to malaria: a systematic review
Abstract Objective To generalize the oral manifestations related to malaria and discuss their clinical significance for health professionals. Materials and methods The bibliographic databases of Public Medline, Embase, Web of Science and Scopus were employed to retrieve publications online from January 1781 to August 2019. Original research articles, clinical trials and case reports published in English were included. Results A small number of studies reported oral manifestations...
Oral Diseases
Mon Jul 13, 2020 12:40

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