Our case of a patient with untreated lymphoplasmacytic lymphoma/Waldenstrom’s macroglobulinemia with extramedullary pleural effusion is the first documented case of pleural fluid MYD88 L265P mutation status in...
Mon Jul 13, 2020 03:00
Abstract Brazil represents the new epicenter of novel coronavirus disease 2019 (COVID‐19), surpassing the mark of more than one million cases and 50,000 deaths. Despite these terrible numbers, experts estimate that the real size of the epidemic may be up to seven times higher (Hallal et al ., 2020). Also, Brazilian people with mild symptoms rarely get tested. While the country and world engage in the fight against the pandemic of COVID‐19, it remains vital for our health care system to continue...
Sun Jul 12, 2020 17:58
Abstract Objective There were rarely investigations on the effects and molecular mechanisms of oral squamous cell carcinoma (OSCC) cells when treated with isorhamnetin. This article assesses the anticancer effect of isorhamnetin. Methods and Materials OSCC cells were treated with or without isorhamnetin. Cell proliferation, cell cycle arrest, cell migration, cell death and the related signaling pathways were evaluated. Results The results revealed that cell proliferation was inhibited...
Sun Jul 12, 2020 17:34
Sun Jul 12, 2020 11:44
Publication date: Available online 12 July 2020Source: Journal of Neuroscience MethodsAuthor(s): Adriana K. Cushnie, Hala G. El-Nahal, Martin O. Bohlen, Paul J. May, Michele A. Basso, Piercesare Grimaldi, Maya Zhe Wang, Ezequiel Marron Fernandez de Velasco, Marc A. Sommer, Sarah R. Heilbronner
Mon Jul 13, 2020 13:20
Publication date: Available online 12 July 2020Source: Journal of Neuroscience MethodsAuthor(s): Timothy J. Fawcett, Chad S. Cooper, Ryan J. Longenecker, Joseph P. Walton
Mon Jul 13, 2020 13:20
Abstract This technical report describes a workflow to fabricate an implant overdenture via digital duplication of an interim complete removable dental prosthesis and additive manufacturing (3D printing). An edentulous patient was provided with an interim maxillary denture after implant placement. After 4 months of healing, the existing interim denture was scanned, duplicated via 3D printing, and used to make the final impression, record the maxillomandibular interocclusal relationship, and transfer...
Sun Jul 12, 2020 21:33
ABSTRACT Purpose To compare the cytotoxicity of six commercially available denture adhesives on human gingival cells: Poligrip Flavour Free Fixative Cream, Fixodent Pro Duo Protection, Novafix cream, FittyDent, Polident Total Action and Fixodent Pro Plus Duo Protection. Material and Methods Eluates of denture adhesives were brought into contact with human gingival cells and compared to untreated cells (w/o any dental adhesive elute). Cell toxicity was assessed by measuring cell viability...
Sun Jul 12, 2020 21:24
Objectives Guidelines recommend to initiate anticoagulation within 4‐14 days after cardioembolic stroke. Data supporting this did not account for key factors potentially affecting the decision to initiate anticoagulation such as infarct size, hemorrhagic transformation, or high risk features on echocardiography. Methods We pooled data from stroke registries of 8 comprehensive stroke centers across the United States. We included consecutive patients admitted with ischemic stroke and atrial...
Sun Jul 12, 2020 20:19
Abstract Background A lower exposure to the natural environment has been hypothesized to adversely affect the human microbiome and its immunomodulatory capacity. However,the underlying effects of this hypothesis are stillnot understood. We aimed to evaluate the effect of early‐life exposure to greenness and species richness on the development of allergic diseases and asthma in children. Methods A longitudinal study was conducted comprising 1050 children from a population‐based birth cohort...
Sun Jul 12, 2020 11:33
Sat Jul 11, 2020 11:17
Key points Limb‐girdle muscular dystrophy R1 (LGMD R1) is caused by mutations in the CAPN3 gene and is characterized by progressive muscle loss, impaired mitochondrial function and reductions in the slow oxidative gene expression program. Myostatin is a negative regulator of muscle growth, and its inhibition improves the phenotype in several muscle wasting disorders. In these studies, we tested the effect of genetic and pharmacological inhibition of myostatin signalling on the disease phenotype...
Sun Jul 12, 2020 20:53
Abstract Background Extracellular fluid volume (ECF) is independently associated with chronic kidney disease (CKD) progression and mortality in patients with CKD, but the prognostic value of the trajectory of ECF over time beyond that of baseline value is unknown. Objectives To characterize ECF trajectory and evaluate its association with the risks of end‐stage kidney disease (ESKD) and mortality. Methods From the prospective tricentric NephroTest cohort, we included...
Sun Jul 12, 2020 22:34
The sacrum in carnivores has evolved in response to the locomotor requirements of the species analysed, but in locomotion, each family has followed alternative morphological solutions to address the same functional demands. Abstract The sacrum is a key piece of the vertebrate skeleton, since it connects the caudal region with the presacral region of the vertebral column and the hind limbs through the pelvis. Therefore, understanding its form and function is of great relevance in vertebrate...
Sun Jul 12, 2020 17:30
We observed that the styloid process of the distal ulna had a ridge on its dorsoradial aspect, corresponding to the chondral‐apophyseal entheses of the radioulnar ligaments. The directions of the radioulnar ligaments were sterically intersected, which may better satisfy both slipping stability and rotational mobility. Abstract The radioulnar ligaments are the major stabilizers of the distal radioulnar joint under dynamic loading; however, anatomical detail regarding their attachment on the...
Sun Jul 12, 2020 17:24
Presented herein is an unprecedented Ir/f‐amphox‐catalyzed asymmetric hydrogenation of racemic 2,3‐syn‐dihydroxy‐1,4‐diones via dynamic kinetic resolution to produce (1R,2R,3R,4R)‐tetraols. This protocol constitutes an efficient and straightforward approach to accessing sugar alcohols bearing four contiguous stereocenters. The strategy exhibits various advantages over existing methods, including excellent yields (up to 98%), exceptional stereoselectivities (up to 99:1 dr, 99.9% ee), operational simplicity...
Sun Jul 12, 2020 18:01
‘ Supramolecular eutectogels ’ are an emerging class of materials that have just developed very recently, which offer a new opportunity for generating functional supramolecular gel materials in biocompatible anhydrous or low‐water media. As the first example of supramolecular G4 eutectogels, complexes of natural guanosine and H 3 BO 3 exhibited excellent gelation capacity in choline chloride/alcohol deep eutectic solvents. The as‐prepared supramolecular eutectogels displayed unexpected solvent‐induced...
Sun Jul 12, 2020 17:00
Catalytic combustion is promising in removing trace amount of CH4 to address serious environmental concerns. Supported Pd based catalysts are most effective but often suffer from low stability in practice application due to the water vapor induced sintering. Herein, we developed a universal strategy to prepare irreducible‐oxide modified Pd/MgAl2O4 catalysts which show high activity and excellent stability aganist both hydrothemal aging at elevated temperatures and deactivation in long‐term reaction...
Sun Jul 12, 2020 17:00
Like other discotic molecules, self‐assembled supramolecular structures of perylene bisimides (PBIs) are commonly limited to columnar or lamellar structures due to their distinct π‐conjugated scaffolds and unique rectangular shape of perylene cores. The discovery of PBIs with supramolecular structures beyond layers and columns may expand the scope of PBI‐based materials. Herein, we report a series of unconventional spherical packing phases in PBIs including A15 phase, σ phase, dodecagonal quasicrystalline...
Sun Jul 12, 2020 16:58
While halogenation is of key importance in synthesis and radioimaging, the currently available repertoire is largely designed to introduce a single halogen per molecule. This report makes the selective introduction of several different halogens accessible. We showcase the privileged stability of non‐toxic aryl germanes under harsh fluorination conditions (that allow for selective fluorination in their presence), while displaying superior reactivity and functional group tolerance in electrophilic...
Sun Jul 12, 2020 16:58
New Findings What is the central question of this study? How dose spinal cord injury affects the prefrontal cortex function and expression of dopamine receptors? What is the main finding and its importance? Spinal cord injury impaired the cognitive function in this study, which is approved by decreased dopamine receptors expression in the prefrontal cortex. Abstract The effect of spinal cord injury (SCI) is widely studied on paraplegia and motor areas of the brain, but...
Sun Jul 12, 2020 18:28
Abstract Sexual selection and conflict can act on genes with important metabolic functions, potentially shaping standing genetic variance in such genes, and thus evolutionary potential of populations. Here, using experimental evolution, we show how reproductive competition intensity and thermal environment affect selection on phosphogluconate dehydrogenase (6Pgdh ) – a metabolic gene involved in sexual selection and conflict in the bulb mite. The S allele of 6Pgdh increases male success in reproductive...
Sun Jul 12, 2020 17:18
Background To analyze and identify the circular RNAs (circRNAs) involved in promoting the osteogenic differentiation of human bone mesenchymal stem cells (hBMSCs) on titanium by surface mechanical attrition treatment (SMAT). Methods The experimental material was SMAT titanium and the control material was annealed titanium. Cell Counting Kits-8 (CCK-8) was used to detect the proliferation of hBMSCs, and alkaline phosphatase (ALP) activity and alizarin red staining were used to detect the...
Mon Jul 13, 2020 03:00
Potato (Solanum tuberosum L.) is the third most economically important crop in the world and has a high nutritional value. In this study, the in vitro culture response of four widely grown in Kazakhstan potato cultivars, Astanalyk, Monument Kunaev, Tokhtar, and Aksor, was investigated using stem and leaf explants. Published protocols were evaluated and optimized to develop a more efficient protocol for the regeneration of plants from local potato cultivars in tissue culture, which is a prerequisite...
Mon Jul 13, 2020 03:00
Maples (Acer) are among the most diverse and ecologically important tree genera of the north-temperate forests. They include species highly valued as ornamentals and as a source of timber and sugar products. Previous phylogenetic studies employing plastid markers have not provided sufficient resolution, particularly at deeper nodes, leaving the backbone of the maple plastid tree essentially unresolved. We provide the plastid genome sequences of 16 species of maples spanning the sectional diversity...
Mon Jul 13, 2020 03:00
The microcirculation plays a crucial role in the distribution of perfusion to organs. Studies have shown that microcirculatory dysfunction is an independent predictor of morbidity and mortality. Hence, assessment of liver perfusion offers valuable information on the (patho)physiological state of the liver. The current review explores techniques in perfusion imaging that can be used intraoperatively. Available modalities include dynamic contrast-enhanced ultrasound, handheld vital microscopes, indocyanine...
Mon Jul 13, 2020 08:08
Ten‐minute repetitive (30 seconds on 30 seconds off) cold oral stimulation was able to induce significant excitability changes in pharyngeal motor cortex measured by pharyngeal motor evoked potentials (PMEP) using transcranial magnetic stimulation. Abstract Background Thermal tactile oropharyngeal stimulation has been clinically used to facilitate swallowing initiation in dysphagic patients. We previously demonstrated that thermal stimulation applied to the oral cavity provokes an immediate...
Sun Jul 12, 2020 22:00
Abstract Background The G protein‐coupled bile acid (BA) receptor, GPBA (previously named TGR5), mediates BA gastrointestinal (GI) activities. Our aim was to elucidate the mucosal and motility responses to selective GPBA agonists compared with conjugated BA (eg, taurodeoxycholate, TDCA) in mouse and human colon. Methods Ion transport responses to GPBA agonists or BAs were measured in mucosal preparations with intact submucous innervation, from C57Bl/6, PYY−/−, or GPBA−/− mice and compared...
Sun Jul 12, 2020 17:09
Abstract In cortical circuitry synaptic communication across areas is based on two types of axon terminals, small and large, with modulatory and driving roles, respectively. In contrast, it is not known whether similar synaptic specializations exist for intra‐areal projections. Using anterograde tracing and three‐dimensional reconstruction by electron microscopy (3D‐EM) we asked if large boutons form synapses in the circuit of somatosensory cortical areas 3b and 1. In contrast to observations in...
Sun Jul 12, 2020 17:40
Abstract The human endometrium is an essential component in human reproduction that has the unique characteristic of undergoing cyclic regeneration during each menstrual cycle. Vigorous regeneration after shedding may be sustained by stem/progenitor cells, for which molecular markers have not been fully identified. Although clonality analysis using X chromosome inactivation patterns has shown that normal human endometrial glands are composed of a monoclonal cell population, whether clonal expansion...
Sun Jul 12, 2020 18:28
Abstract Approximately 30% of patients with early stage NSCLC relapse within 5 years after surgery. Therefore, it is necessary to identify a robust and reliable prognostic signature for early stage NSCLC. Immunohistochemistry data from 147 patients with stage I lung adenocarcinoma (stage I‐LUAD) were analyzed for the protein expression of base excision repair (BER), stimulator of interferon genes (STING) and tumor‐infiltrating lymphocytes (TILs) to explore the relationship between protein expression...
Sun Jul 12, 2020 18:14
The metabolic syndrome (MetS) is a cluster of risk factors for cognitive impairment. We aimed to investigate the association between MetS and risk of persistent cognitive impairment in patients with a transient ischemic attack (TIA) or mild ischemic stroke. This is a prospective and observational study in consecutive patients with first-ever TIA or mild stroke (National Institutes of Health Stroke Scale score ≤ 6). Patients underwent Montreal cognitive assessment (MoCA) at hospital admission and...
Fri Jul 10, 2020 03:00
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