RIG-I ligand enhances the immunogenicity of recombinant H7HA protein.

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RIG-I ligand enhances the immunogenicity of recombinant H7HA protein.

Cell Immunol. 2016 Jun-Jul;304-305:55-8

Authors: Cao W, Liepkalns JS, Kamal RP, Reber AJ, Kim JH, Hofstetter AR, Amoah S, Stevens J, Ranjan P, Gangappa S, York IA, Sambhara S

Abstract
Avian H7N9 influenza virus infection with fatal outcomes continues to pose a pandemic threat and highly immunogenic vaccines are urgently needed. In this report we show that baculovirus-derived recombinant H7 hemagglutinin protein, when delivered with RIG-I ligand, induced enhanced antibody and T cell responses and conferred protection against lethal challenge with a homologous H7N9 virus. These findings indicate the potential utility of RIG-I ligands as vaccine adjuvants to increase the immunogenicity of recombinant H7 hemagglutinin.

PMID: 27106062 [PubMed - indexed for MEDLINE]

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