The histological and histomorphometric changes in the mandible after radiotherapy: An animal model

Osteoradionecrosis (ORN) of the mandible is a severe complication after radiotherapy (RT) and develops in approximately 2%-22% of head and neck cancer patients and most often in the mandible (Teng and Futran, 2005). The most accepted definition for ORN is that 'irradiated bone becomes devitalized and is exposed through the overlying skin or mucosa, without tumor recurrence, and does not heal within 3 months' (Lyons and Ghazali, 2008). The current non-surgical treatment options for ORN, such as hyperbaric oxygen therapy and medical treatment, are based on controversial theories and on a limited number of studies (Delanian et al., 2005; Shaw and Dhanda, 2011).

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