Publication date: Available online 1 July 2017
Source:The Journal of Steroid Biochemistry and Molecular Biology
Author(s): Andrzej T. Slominski, Anna A Brozyna, Cezary Skobowiat, Michal A. Zmijewski, Tae-Kang Kim, Zorica Janjetovic, Allen S. Oak, Wojciech Jozwicki, Anton M. Jetten, Rebecca S. Mason, Craig Elmets, We Li, Robert M. Hoffman, Robert C. Tuckey
Melanoma represents a significant clinical problem affecting a large segment of the population with a relatively high incidence and mortality rate. Ultraviolet radiation (UVR) is an important etiological factor in malignant transformation of melanocytes and melanoma development. UVB, while being a full carcinogen in melanomagenesis, is also necessary for the cutaneous production of vitamin D3 (D3). Calcitriol (1,25(OH)2D3) and novel CYP11A1-derived hydroxyderivatives of D3 show anti-melanoma activities and protective properties against damage induced by UVB. The former activities include inhibitory effects on proliferation, plating efficiency and anchorage-independent growth of cultured human and rodent melanomas in vitro, as well as the in vivo inhibition of tumor growth by 20(OH)D3 after injection of human melanoma cells into immunodeficient mice. The literature indicates that low levels of 25(OH)D3 are associated with more advanced melanomas and reduced patient survivals, while single nucleotide polymorphisms of the vitamin D receptor or the D3 binding protein gene affect development or progression of melanoma, or disease outcome. An inverse correlation of VDR and CYP27B1 expression with melanoma progression has been found, with low or undetectable levels of these proteins being associated with poor disease outcomes. Unexpectedly, increased expression of CYP24A1 was associated with better melanoma prognosis. In addition, decreased expression of retinoic acid orphan receptors α and γ, which can also bind vitamin D3 hydroxyderivatives, showed positive association with melanoma progression and shorter disease-free and overall survival. Thus, inadequate levels of biologically active forms of D3 and disturbances in expression of the target receptors or D3 activating or inactivating enzymes, can affect melanomagenesis and disease progression. We therefore propose that inclusion of vitamin D into melanoma management should be beneficial for patients, at least as an adjuvant approach. The presence of multiple hydroxyderivatives of D3 in skin that show anti-melanoma activity in experimental models and which may act on alternative receptors, will be a future consideration when planning which forms of vitamin D to use for melanoma therapy.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
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00302841026182
00306932607174
alsfakia@gmail.com
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On the role of classical and novel forms of vitamin D in melanoma progression and management
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- Chinese versus English: Insights on Cognition duri...
- On the role of classical and novel forms of vitami...
- Vitamin D-deficiency and sex-specific dysregulatio...
- Small molecules to the rescue: Inhibition of cytok...
- Serum cytokine profile in pediatric Sweet’s syndro...
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- The Treatment of Myeloid Malignancies with Kinase ...
- Tyrosine Kinase Inhibitor Treatment for Newly Diag...
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- Muscle synergies reveal impaired trunk muscle coor...
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- Insomnia disorder in adolescence: diagnosis, impac...
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- Effects of residual hearing on cochlear implant ou...
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- Frameshift mutation and loss of expression of PLK2...
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- Sjogren's syndrome: New paradigms and areas for fu...
- Translocator protein (18 kDa): an update on its fu...
- Diffusion-weighted MRI in image-guided adaptive br...
- American Brachytherapy Society consensus report fo...
- Patient preferences for the attributes of a non-in...
- Functional melanoma-risk variant IRF4 rs12203592 a...
- Lack of Response to Intravenous Sodium Thiosulfate...
- Invasive dermatophyte infection with trichophyton ...
- Experiences of rosacea and its treatment: An inter...
- Hidradenitis Suppurativa and electrocardiographic ...
- A hyaluronic acid-based microneedle patch to treat...
- AGREE II assessments of recent acne treatment guid...
- European Heart SCORE may underestimates cardiovasc...
- Patient preferences for the attributes of a non-in...
- Functional melanoma-risk variant IRF4 rs12203592 a...
- Lack of Response to Intravenous Sodium Thiosulfate...
- Invasive dermatophyte infection with trichophyton ...
- Experiences of rosacea and its treatment: An inter...
- Hidradenitis Suppurativa and electrocardiographic ...
- A hyaluronic acid-based microneedle patch to treat...
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- Peak inspiratory flow as predictor for tracheotomy
- A pigmented lesion of the nasopharynx
- Oral shedding of human herpesviruses in renal tran...
- Effect of root canal preparation techniques on chl...
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