Publication date: Available online 1 July 2017
Source:Journal of Dermatological Science
Author(s): Yinjuan Wang, Céline Viennet, Sophie Robin, Jean-Yves Berthon, Li He, Philippe Humbert
Dermal fibroblasts are traditionally recognized as synthesizing, remodeling and depositing collagen and extracellular matrix, the structural framework for tissues, helping to bring thickness and firmness to the skin. However, the role of fibroblasts on skin pigmentation arouses concern recently. More is known about the interactions between epidermal melanocytes and keratinocytes.This review highlights the importance of fibroblast-derived melanogenic paracrine mediators in the regulation of melanocyte activities. Fibroblasts act on melanocytes directly and indirectly through neighboring cells by secreting a large number of cytokines (SCF), proteins (DKK1, sFRP, Sema7a, CCN, FAP-α) and growth factors (KGF, HGF, bFGF, NT-3, NRG-1, TGF-β) which bind to receptors and modulate intracellular signaling cascades (MAPK/ERK, cAMP/PKA, Wnt/β-catenin, PI3K/Akt) related to melanocyte functions. These factors influence the growth, the pigmentation of melanocytes via the expression of melanin-producing enzymes and melanosome transfer, as well as their dendricity, mobility and adhesive properties. Thus, fibroblasts are implicated in both skin physiological and pathological pigmentation. In order to investigate their contribution, various in vitro models have been developed, based on cellular senescence. UV exposure, a major factor implicated in pigmentary disorders, may affect the secretory crosstalk between dermal and epithelial cells.Therefore, identification of the interactions between fibroblasts and melanocytes could provide novel insights not only for the development of melanogenic agents in the clinical and cosmetic fields, but also for a better understanding of the melanocyte biology and melanogenesis regulation.
http://ift.tt/2tc9bln
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
-
▼
Ιουλίου
(7890)
-
▼
Ιουλ 01
(173)
- Meditation is associated with increased brain netw...
- Correction of metal-induced susceptibility artifac...
- Epinephrine use for anaphylaxis: Too seldom, too late
- Effects of allergen sensitization on response to t...
- Epinephrine use for anaphylaxis: Too seldom, too late
- Effects of allergen sensitization on response to t...
- Chinese versus English: Insights on Cognition duri...
- On the role of classical and novel forms of vitami...
- Vitamin D-deficiency and sex-specific dysregulatio...
- Small molecules to the rescue: Inhibition of cytok...
- Serum cytokine profile in pediatric Sweet’s syndro...
- Copyright
- Contributors
- Contents
- Forthcoming Issues
- Kinase Inhibitors in the Treatment of Myeloid Mali...
- The Treatment of Myeloid Malignancies with Kinase ...
- Tyrosine Kinase Inhibitor Treatment for Newly Diag...
- Mechanisms of Resistance to ABL Kinase Inhibition ...
- Tyrosine Kinase Inhibitors in the Treatment of Eos...
- Muscle synergies reveal impaired trunk muscle coor...
- Serum cytokine profile in pediatric Sweet’s syndro...
- Table of Contents
- Guidelines for Contributing Authors
- Editorial Board
- Trends in prescribing behavior of systemic agents ...
- Anatomic mapping and clinicopathologic analysis of...
- CD8+ mycosis fungoides: A low-grade lymphoprolifer...
- Discrepancy between the clinical and histopatholog...
- Multiple and repeated sampling increases the sensi...
- Evaluation of laser fluorescence in monitoring non...
- Urolithiasis secondary to primary obstructive mega...
- Speech–language pathology in paediatric palliative...
- Fluency adaptation in speakers with Parkinson dise...
- Urolithiasis secondary to primary obstructive mega...
- Suppressive effects of thermal-treated oyster shel...
- Insomnia disorder in adolescence: diagnosis, impac...
- Simultaneous effect of dissolved organic carbon, s...
- Hearing loss in children with growth hormone defic...
- Intracranial complications of CSOM in pediatric pa...
- Effects of residual hearing on cochlear implant ou...
- Resolution of bilateral sensorineural hearing loss...
- Exploring reasons for late identification of child...
- Modeling Learning in Surgical Practice
- Residents and Program Director Perspectives Often ...
- A New Synthetic Model for Microvascular Anastomosi...
- Identification of cytidine-5-triphosphate synthase...
- Down-regulated microRNA-375 expression as a predic...
- Frameshift mutation and loss of expression of PLK2...
- Prevalence of Protein C Receptor (PROCR) is Associ...
- Morphology based scoring of Chromosomal instabilit...
- The role of ARMC5 in human cell cultures from nodu...
- Ecotoxicity of 1,3-dichloropropene, metam sodium, ...
- Improved SNR for combined TMS-fMRI: A support devi...
- Improving gentamicin B and gentamicin C1a producti...
- Influence of environmental factors on absorption c...
- Spinal muscular atrophy carriers with two SMN1 copies
- β-elemene regulates endoplasmic reticulum stress t...
- Pooled Analysis of Clinical Outcome of Patients wi...
- Sjogren's syndrome: New paradigms and areas for fu...
- Sjogren's syndrome: New paradigms and areas for fu...
- Translocator protein (18 kDa): an update on its fu...
- Diffusion-weighted MRI in image-guided adaptive br...
- American Brachytherapy Society consensus report fo...
- Patient preferences for the attributes of a non-in...
- Functional melanoma-risk variant IRF4 rs12203592 a...
- Lack of Response to Intravenous Sodium Thiosulfate...
- Invasive dermatophyte infection with trichophyton ...
- Experiences of rosacea and its treatment: An inter...
- Hidradenitis Suppurativa and electrocardiographic ...
- A hyaluronic acid-based microneedle patch to treat...
- AGREE II assessments of recent acne treatment guid...
- European Heart SCORE may underestimates cardiovasc...
- Patient preferences for the attributes of a non-in...
- Functional melanoma-risk variant IRF4 rs12203592 a...
- Lack of Response to Intravenous Sodium Thiosulfate...
- Invasive dermatophyte infection with trichophyton ...
- Experiences of rosacea and its treatment: An inter...
- Hidradenitis Suppurativa and electrocardiographic ...
- A hyaluronic acid-based microneedle patch to treat...
- AGREE II assessments of recent acne treatment guid...
- European Heart SCORE may underestimates cardiovasc...
- Peak inspiratory flow as predictor for tracheotomy
- A pigmented lesion of the nasopharynx
- Oral shedding of human herpesviruses in renal tran...
- Effect of root canal preparation techniques on chl...
- Editors / Publication Information
- Cultural Competency Training in Emergency Medicine
- Verb Naming Fluency in Hypokinetic and Hyperkineti...
- Room Service Improves Nutritional Intake and Incre...
- Development, Construct Validity, and Reliability o...
- Precise role of dermal fibroblasts on melanocyte p...
- CCL3/MIP1α represents a biomarker but not a mandat...
- Polysaccharide matrices used in 3D in vitro cell c...
- L’infection à Zika virus : mise au point
- L’infection à Zika virus : mise au point
- When cancer patients suddenly have a positive preg...
- Review of phase III trial data on IL-23 Inhibitors...
- Selection of patients with left breast cancer for ...
- Theophylline increases saliva sonic hedgehog and i...
-
▼
Ιουλ 01
(173)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Σάββατο 1 Ιουλίου 2017
Precise role of dermal fibroblasts on melanocyte pigmentation
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
-
▼
Ιουλίου
(7890)
-
▼
Ιουλ 01
(173)
- Meditation is associated with increased brain netw...
- Correction of metal-induced susceptibility artifac...
- Epinephrine use for anaphylaxis: Too seldom, too late
- Effects of allergen sensitization on response to t...
- Epinephrine use for anaphylaxis: Too seldom, too late
- Effects of allergen sensitization on response to t...
- Chinese versus English: Insights on Cognition duri...
- On the role of classical and novel forms of vitami...
- Vitamin D-deficiency and sex-specific dysregulatio...
- Small molecules to the rescue: Inhibition of cytok...
- Serum cytokine profile in pediatric Sweet’s syndro...
- Copyright
- Contributors
- Contents
- Forthcoming Issues
- Kinase Inhibitors in the Treatment of Myeloid Mali...
- The Treatment of Myeloid Malignancies with Kinase ...
- Tyrosine Kinase Inhibitor Treatment for Newly Diag...
- Mechanisms of Resistance to ABL Kinase Inhibition ...
- Tyrosine Kinase Inhibitors in the Treatment of Eos...
- Muscle synergies reveal impaired trunk muscle coor...
- Serum cytokine profile in pediatric Sweet’s syndro...
- Table of Contents
- Guidelines for Contributing Authors
- Editorial Board
- Trends in prescribing behavior of systemic agents ...
- Anatomic mapping and clinicopathologic analysis of...
- CD8+ mycosis fungoides: A low-grade lymphoprolifer...
- Discrepancy between the clinical and histopatholog...
- Multiple and repeated sampling increases the sensi...
- Evaluation of laser fluorescence in monitoring non...
- Urolithiasis secondary to primary obstructive mega...
- Speech–language pathology in paediatric palliative...
- Fluency adaptation in speakers with Parkinson dise...
- Urolithiasis secondary to primary obstructive mega...
- Suppressive effects of thermal-treated oyster shel...
- Insomnia disorder in adolescence: diagnosis, impac...
- Simultaneous effect of dissolved organic carbon, s...
- Hearing loss in children with growth hormone defic...
- Intracranial complications of CSOM in pediatric pa...
- Effects of residual hearing on cochlear implant ou...
- Resolution of bilateral sensorineural hearing loss...
- Exploring reasons for late identification of child...
- Modeling Learning in Surgical Practice
- Residents and Program Director Perspectives Often ...
- A New Synthetic Model for Microvascular Anastomosi...
- Identification of cytidine-5-triphosphate synthase...
- Down-regulated microRNA-375 expression as a predic...
- Frameshift mutation and loss of expression of PLK2...
- Prevalence of Protein C Receptor (PROCR) is Associ...
- Morphology based scoring of Chromosomal instabilit...
- The role of ARMC5 in human cell cultures from nodu...
- Ecotoxicity of 1,3-dichloropropene, metam sodium, ...
- Improved SNR for combined TMS-fMRI: A support devi...
- Improving gentamicin B and gentamicin C1a producti...
- Influence of environmental factors on absorption c...
- Spinal muscular atrophy carriers with two SMN1 copies
- β-elemene regulates endoplasmic reticulum stress t...
- Pooled Analysis of Clinical Outcome of Patients wi...
- Sjogren's syndrome: New paradigms and areas for fu...
- Sjogren's syndrome: New paradigms and areas for fu...
- Translocator protein (18 kDa): an update on its fu...
- Diffusion-weighted MRI in image-guided adaptive br...
- American Brachytherapy Society consensus report fo...
- Patient preferences for the attributes of a non-in...
- Functional melanoma-risk variant IRF4 rs12203592 a...
- Lack of Response to Intravenous Sodium Thiosulfate...
- Invasive dermatophyte infection with trichophyton ...
- Experiences of rosacea and its treatment: An inter...
- Hidradenitis Suppurativa and electrocardiographic ...
- A hyaluronic acid-based microneedle patch to treat...
- AGREE II assessments of recent acne treatment guid...
- European Heart SCORE may underestimates cardiovasc...
- Patient preferences for the attributes of a non-in...
- Functional melanoma-risk variant IRF4 rs12203592 a...
- Lack of Response to Intravenous Sodium Thiosulfate...
- Invasive dermatophyte infection with trichophyton ...
- Experiences of rosacea and its treatment: An inter...
- Hidradenitis Suppurativa and electrocardiographic ...
- A hyaluronic acid-based microneedle patch to treat...
- AGREE II assessments of recent acne treatment guid...
- European Heart SCORE may underestimates cardiovasc...
- Peak inspiratory flow as predictor for tracheotomy
- A pigmented lesion of the nasopharynx
- Oral shedding of human herpesviruses in renal tran...
- Effect of root canal preparation techniques on chl...
- Editors / Publication Information
- Cultural Competency Training in Emergency Medicine
- Verb Naming Fluency in Hypokinetic and Hyperkineti...
- Room Service Improves Nutritional Intake and Incre...
- Development, Construct Validity, and Reliability o...
- Precise role of dermal fibroblasts on melanocyte p...
- CCL3/MIP1α represents a biomarker but not a mandat...
- Polysaccharide matrices used in 3D in vitro cell c...
- L’infection à Zika virus : mise au point
- L’infection à Zika virus : mise au point
- When cancer patients suddenly have a positive preg...
- Review of phase III trial data on IL-23 Inhibitors...
- Selection of patients with left breast cancer for ...
- Theophylline increases saliva sonic hedgehog and i...
-
▼
Ιουλ 01
(173)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου