Publication date: Available online 1 July 2017
Source:Molecular and Cellular Endocrinology
Author(s): Isadora P. Cavalcante, Miriam Nishi, Maria Claudia N. Zerbini, Madson Q. Almeida, Vania B. Brondani, Maria Lucia Botelho, Fabio Y. Tanno, Victor Srougi, José Luis Chambo, Berenice B. Mendonça, Jerôme Bertherat, Claudimara Ferini Pacicco Lotfi, Maria Candida B.V. Fragoso
The participation of aberrant receptors and intra-adrenal ACTH in hyperplastic tissue are considered mechanisms that regulate hypercortisolism in PMAH. Additionally, germline ARMC5 mutations have been described as the most frequent genetic abnormality found in patients diagnosed with PMAH. Previous functional studies analyzed ARMC5 role using H295R cells. Therefore, we investigated the role of ARMC5 in cell cultures obtained from PMAH nodules containing steroidogenic cells, aberrant receptors and intra-adrenal ACTH. ARMC5 silencing in non-mutated PMAH cell cultures decreased steroidogenesis-related genes and increased CCNE1 mRNA expression and proliferative capacity without affecting cell viability. Additionally, ARMC5 overexpression induced cell death in PMAH mutated cell cultures, thereby decreasing cell viability. We confirmed the role of ARMC5 as an important pro-apoptotic protein involved in PMAH-related steroidogenesis. We also report for the first time the involvement of ARMC5 in controlling proliferation and regulating cell cycle in PMAH cell cultures; these effects need to be explored further.
http://ift.tt/2sdnHYv
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- Epinephrine use for anaphylaxis: Too seldom, too late
- Effects of allergen sensitization on response to t...
- Epinephrine use for anaphylaxis: Too seldom, too late
- Effects of allergen sensitization on response to t...
- Chinese versus English: Insights on Cognition duri...
- On the role of classical and novel forms of vitami...
- Vitamin D-deficiency and sex-specific dysregulatio...
- Small molecules to the rescue: Inhibition of cytok...
- Serum cytokine profile in pediatric Sweet’s syndro...
- Copyright
- Contributors
- Contents
- Forthcoming Issues
- Kinase Inhibitors in the Treatment of Myeloid Mali...
- The Treatment of Myeloid Malignancies with Kinase ...
- Tyrosine Kinase Inhibitor Treatment for Newly Diag...
- Mechanisms of Resistance to ABL Kinase Inhibition ...
- Tyrosine Kinase Inhibitors in the Treatment of Eos...
- Muscle synergies reveal impaired trunk muscle coor...
- Serum cytokine profile in pediatric Sweet’s syndro...
- Table of Contents
- Guidelines for Contributing Authors
- Editorial Board
- Trends in prescribing behavior of systemic agents ...
- Anatomic mapping and clinicopathologic analysis of...
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- Discrepancy between the clinical and histopatholog...
- Multiple and repeated sampling increases the sensi...
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- Speech–language pathology in paediatric palliative...
- Fluency adaptation in speakers with Parkinson dise...
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- Suppressive effects of thermal-treated oyster shel...
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- Simultaneous effect of dissolved organic carbon, s...
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- Intracranial complications of CSOM in pediatric pa...
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- Residents and Program Director Perspectives Often ...
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- Translocator protein (18 kDa): an update on its fu...
- Diffusion-weighted MRI in image-guided adaptive br...
- American Brachytherapy Society consensus report fo...
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- Lack of Response to Intravenous Sodium Thiosulfate...
- Invasive dermatophyte infection with trichophyton ...
- Experiences of rosacea and its treatment: An inter...
- Hidradenitis Suppurativa and electrocardiographic ...
- A hyaluronic acid-based microneedle patch to treat...
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- European Heart SCORE may underestimates cardiovasc...
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- Invasive dermatophyte infection with trichophyton ...
- Experiences of rosacea and its treatment: An inter...
- Hidradenitis Suppurativa and electrocardiographic ...
- A hyaluronic acid-based microneedle patch to treat...
- AGREE II assessments of recent acne treatment guid...
- European Heart SCORE may underestimates cardiovasc...
- Peak inspiratory flow as predictor for tracheotomy
- A pigmented lesion of the nasopharynx
- Oral shedding of human herpesviruses in renal tran...
- Effect of root canal preparation techniques on chl...
- Editors / Publication Information
- Cultural Competency Training in Emergency Medicine
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- Development, Construct Validity, and Reliability o...
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