Publication date: Available online 2 July 2017
Source:Journal of Autoimmunity
Author(s): M. Introna
Cytokine Induced Killer (CIK) cells are ex vivo expanded and activated T lymphocytes obtained by sequential incubation of Peripheral Blood Mononuclear cells (PBMNC) with Interferon γ (IFNG), anti CD3 monoclonal antibody OKT3 and IL2.These cells, while retaining few characteristics of the Effector memory T cells subpopulation, acquired during culture CD56 expression, as well as non specific, Natural Killer like, anti tumoral cytotoxicity.CIK cells from human are equivalent to expanded NKT cells in mouse.More interestingly, CIK cells show a potent intratumoral homing in several experimental models, followed by anti tumoral clinical activity in mice and humans.In spite of extensive in vivo permanence and proliferation, CIK cells do not show cytotoxicity against normal targets and, particularly important, do not show Graft versus host disease when tested in allogeneic combinations (donor versus host) even in the haploidentical matching.For the easiness of the laboratory preparations, the availability of clinical grade reagents, the production of Good Manufacturing Practice compliant methods, CIK cells have been extensively used for the treatment of cancer patients, in both hematologic and solid tumors, in both autologous and allogeneic combinations.Several clinical protocol will be here discussed and summarised to show the feasibility of these passive transfer approaches, and also their very limited toxicity. Finally, preliminary indications on clinical efficacy, particularly in hematologic malignancies and against minimal residual disease, will be shown and discussed, as well as the future perspectives to optimize this adoptive passive cell immunotherapy strategy by gene transfer technology or bispecific monoclonal antibodies addition.
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CIK as therapeutic agents against tumors
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- Re-evaluating Strategies to Define the Immunoregul...
- Molecular Dissection of CD8+ T-Cell Dysfunction
- Consecutive occurrence of isotopic and isomorphic ...
- Superficial plantar angiomyxoma in a young man
- Consecutive occurrence of isotopic and isomorphic ...
- Superficial plantar angiomyxoma in a young man
- The dog days or dog days of summer are the hot, su...
- Brassica rapa hairy root extracts promote skin dep...
- Brassica rapa hairy root extracts promote skin dep...
- Measurement of Pharyngo-laryngeal Volume During Sw...
- Subcutaneous mycoses in Peru: a systematic review ...
- Burden and health-related quality of life of eatin...
- Issue Information
- CIK as therapeutic agents against tumors
- A Case of Atopic Myelitis with Cervical Cavernous ...
- A call to arms of specialty societies to review th...
- The atopic disorders and atopy … “strange diseases...
- Atopic dermatitis treatment: Current state of the ...
- Efficacy and safety of omalizumab in children and ...
- A 6-month safety and efficacy study of fluticasone...
- Asthma in older people hospitalized with influenza...
- Prevalence and triggers of anaphylactic events in ...
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- A call to arms of specialty societies to review th...
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- Atopic dermatitis treatment: Current state of the ...
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- A 6-month safety and efficacy study of fluticasone...
- Asthma in older people hospitalized with influenza...
- Prevalence and triggers of anaphylactic events in ...
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- Association of maternal depression and allergic di...
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- A 28-year-old woman with fever, rash, and pancytop...
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- Abstracts from the New England Society of Allergy ...
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- Multiple Non-Syndromic Bilaterally Erupted Para Pr...
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- Defect of the Eyelids
- Flap Basics III
- Forthcoming Issues
- Flap Basics II
- Index
- Repair of Auricular Defects
- Facial Reconstruction Post-Mohs Surgery
- Reconstruction of Mohs Defects of the Lips and Chin
- Reconstruction of Cheek Defects Secondary to Mohs ...
- Copyright
- In Pursuit of Perfection: The Art of Facial Restor...
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- Contents
- Skin and Composite Grafting Techniques in Facial R...
- Defect of the Eyelids
- Flap Basics III
- Forthcoming Issues
- Flap Basics II
- Index
- Repair of Auricular Defects
- Facial Reconstruction Post-Mohs Surgery
- Reconstruction of Mohs Defects of the Lips and Chin
- Reconstruction of Cheek Defects Secondary to Mohs ...
- Copyright
- In Pursuit of Perfection: The Art of Facial Restor...
- Personality predicts the vibrancy of colour imager...
- Emergency Department Flow Measures for Adult and P...
- Autophagy inhibition enabled efficient phototherma...
- Editorial board
- Macrophages with cellular backpacks for targeted d...
- Effects of allergen sensitization on response to t...
- Epinephrine use for anaphylaxis: Too seldom, too late
- Corrigendum to “Management Challenges in a Child w...
- Efficacy of oral immunotherapy with a rice-based e...
- Prodrugs in medicinal chemistry and enzyme prodrug...
- Serum Wisteria floribunda agglutinin-positive Mac-...
- Acceleration of skin wound healing by low-dose ind...
- High frequencies of a favorable IL-28B rs8099917 p...
- Evaluation of Sedation-Related Medication Errors i...
- Synthesis and biological evaluation of novel stero...
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