Publication date: Available online 26 June 2017
Source:Trends in Immunology
Author(s): Chao Wang, Meromit Singer, Ana C. Anderson
Chronic viral infections and cancer often lead to the emergence of dysfunctional or 'exhausted' CD8+ T cells, and the restoration of their functions is currently the focus of therapeutic interventions. In this review, we detail recent advances in the annotation of the gene modules and the epigenetic landscape associated with T-cell dysfunction. Together with analysis of single-cell transcriptomes, these findings have enabled a deeper and more precise understanding of the transcriptional mechanisms that induce and maintain the dysfunctional state and highlight the heterogeneity of CD8+ T-cell phenotypes present in chronically inflamed tissue. We discuss the relevance of these findings for understanding the transcriptional and spatial regulation of dysfunctional T cells and for the design of therapeutics.
http://ift.tt/2tA7UXM
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Κυριακή 2 Ιουλίου 2017
Molecular Dissection of CD8+ T-Cell Dysfunction
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- Head and Neck Diseases
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- Host Genetics and Gut Microbiome: Challenges and P...
- Re-evaluating Strategies to Define the Immunoregul...
- Molecular Dissection of CD8+ T-Cell Dysfunction
- Consecutive occurrence of isotopic and isomorphic ...
- Superficial plantar angiomyxoma in a young man
- Consecutive occurrence of isotopic and isomorphic ...
- Superficial plantar angiomyxoma in a young man
- The dog days or dog days of summer are the hot, su...
- Brassica rapa hairy root extracts promote skin dep...
- Brassica rapa hairy root extracts promote skin dep...
- Measurement of Pharyngo-laryngeal Volume During Sw...
- Subcutaneous mycoses in Peru: a systematic review ...
- Burden and health-related quality of life of eatin...
- Issue Information
- CIK as therapeutic agents against tumors
- A Case of Atopic Myelitis with Cervical Cavernous ...
- A call to arms of specialty societies to review th...
- The atopic disorders and atopy … “strange diseases...
- Atopic dermatitis treatment: Current state of the ...
- Efficacy and safety of omalizumab in children and ...
- A 6-month safety and efficacy study of fluticasone...
- Asthma in older people hospitalized with influenza...
- Prevalence and triggers of anaphylactic events in ...
- Seasonal variation and monthly patterns of skin sy...
- Association of maternal depression and allergic di...
- A 10-year experience of a novel and safe modified ...
- Pearls and pitfalls: Autoimmune lymphoproliferativ...
- A 28-year-old woman with fever, rash, and pancytop...
- For the Patient: Prevalence and triggers of anaphy...
- Abstracts from the New England Society of Allergy ...
- A call to arms of specialty societies to review th...
- The atopic disorders and atopy … “strange diseases...
- Atopic dermatitis treatment: Current state of the ...
- Efficacy and safety of omalizumab in children and ...
- A 6-month safety and efficacy study of fluticasone...
- Asthma in older people hospitalized with influenza...
- Prevalence and triggers of anaphylactic events in ...
- Seasonal variation and monthly patterns of skin sy...
- Association of maternal depression and allergic di...
- A 10-year experience of a novel and safe modified ...
- Pearls and pitfalls: Autoimmune lymphoproliferativ...
- A 28-year-old woman with fever, rash, and pancytop...
- For the Patient: Prevalence and triggers of anaphy...
- Abstracts from the New England Society of Allergy ...
- Assessment of complete unilateral cleft lip and pa...
- Can Residents Be Trained and Safety Maintained?
- Multiple Non-Syndromic Bilaterally Erupted Para Pr...
- NCI UNC Project ESCC
- Eltrombopag for People With Fanconi Anemia
- NCI UNC Project ESCC
- Eltrombopag for People With Fanconi Anemia
- Contributors
- Contents
- Skin and Composite Grafting Techniques in Facial R...
- Defect of the Eyelids
- Flap Basics III
- Forthcoming Issues
- Flap Basics II
- Index
- Repair of Auricular Defects
- Facial Reconstruction Post-Mohs Surgery
- Reconstruction of Mohs Defects of the Lips and Chin
- Reconstruction of Cheek Defects Secondary to Mohs ...
- Copyright
- In Pursuit of Perfection: The Art of Facial Restor...
- Contributors
- Contents
- Skin and Composite Grafting Techniques in Facial R...
- Defect of the Eyelids
- Flap Basics III
- Forthcoming Issues
- Flap Basics II
- Index
- Repair of Auricular Defects
- Facial Reconstruction Post-Mohs Surgery
- Reconstruction of Mohs Defects of the Lips and Chin
- Reconstruction of Cheek Defects Secondary to Mohs ...
- Copyright
- In Pursuit of Perfection: The Art of Facial Restor...
- Personality predicts the vibrancy of colour imager...
- Emergency Department Flow Measures for Adult and P...
- Autophagy inhibition enabled efficient phototherma...
- Editorial board
- Macrophages with cellular backpacks for targeted d...
- Effects of allergen sensitization on response to t...
- Epinephrine use for anaphylaxis: Too seldom, too late
- Corrigendum to “Management Challenges in a Child w...
- Efficacy of oral immunotherapy with a rice-based e...
- Prodrugs in medicinal chemistry and enzyme prodrug...
- Serum Wisteria floribunda agglutinin-positive Mac-...
- Acceleration of skin wound healing by low-dose ind...
- High frequencies of a favorable IL-28B rs8099917 p...
- Evaluation of Sedation-Related Medication Errors i...
- Synthesis and biological evaluation of novel stero...
- Staged definitive repair after carotid blowout: a ...
- Joint Attention and Oromotor Abilities in Young Ch...
- Geospatial analysis of dissolved nutrients dataset...
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