Related Articles An observational study of drug utilization and associated outcomes among adult patients diagnosed with BRAF-mutant advanced melanoma treated with first-line anti-PD-1 monotherapies or BRAF/MEK inhibitors in a community-based oncology setting. Cancer Med. 2020 Sep 01;: Authors: Cowey CL, Boyd M, Aguilar KM, Beeks A, Krepler C, Scherrer E Abstract INTRODUCTION: Anti-PD-1 monotherapies (aPD-1) and BRAF/MEK inhibitors (BRAF/MEKi)...
Wed Sep 02, 2020 14:41
Related Articles Improving Root Cause Analysis of Patient Safety Events in Radiology. Radiographics. 2020 Sep-Oct;40(5):1434-1440 Authors: Rosier AS, Tibor LC, Turner MA, Phillips CJ, Kurup AN Abstract Patient safety events occur in health care, and root cause analysis (RCA) meetings held after these incidents often reveal valuable insights into systemic barriers between optimal processes or stated policies and actual practice, providing critical...
Wed Sep 02, 2020 14:41
Related Articles Micropapillary pattern of stage IIIA-N2 lung adenocarcinoma is a prognostic factor after adjuvant chemoradiotherapy. Future Oncol. 2020 Sep 01;: Authors: Zeng J, Cui X, Cheng L, Chen Y, Du X, Sheng L Abstract Aim: This study aims to investigate the significance of a micropapillary pattern in stage IIIA-N2 lung adenocarcinoma after adjuvant chemoradiotherapy. Patients & methods: A total of 257 patients with stage IIIA-N2...
Wed Sep 02, 2020 14:41
Related Articles The clinical significance of routine risk categorization in metastatic renal cell carcinoma and its impact on treatment decision-making: a systematic review. Future Oncol. 2020 Sep 01;: Authors: Bazarbashi S, Alsharm A, Azam F, Ashry HE, Zekri J Abstract Aim: To analyze responses to first-line metastatic renal cell carcinoma (mRCC) treatment stratified by risk criteria. Patients & methods: Clinical trials and observational...
Wed Sep 02, 2020 14:41
Related Articles Network meta-analysis of first-line therapy for advanced EGFR mutation positive non-small-cell lung cancer: updated overall survival. Future Oncol. 2020 Sep 01;: Authors: Farris MS, Larkin-Kaiser KA, Scory T, Boyne D, Wilner KD, Pastel M, Cappelleri JC, Ivanova JI Abstract Aim: To update overall survival (OS) results from a previous network meta-analysis comparing the relative clinical efficacy of epidermal growth factor receptor-targeted...
Wed Sep 02, 2020 14:41
Related Articles Multivariate gene expression-based survival predictor model in esophageal adenocarcinoma. Thorac Cancer. 2020 Sep 01;: Authors: Zhao M, Wang J, Yuan M, Ma Z, Bao Y, Hui Z Abstract BACKGROUND: Despite the recent development of molecular-targeted treatment and immunotherapy, survival of patients with esophageal adenocarcinoma (EAC) with poor prognosis is still poor due to lack of an effective biomarker. In this study, we aimed...
Wed Sep 02, 2020 14:41
Related Articles Alectinib following brigatinib: an efficient sequence for the treatment of advanced anaplastic lymphoma kinase-positive lung cancer patients. Anticancer Drugs. 2020 Aug 27;: Authors: Hochmair MJ, Prosch H, Krenbek D, Weinlinger C, Fabikan H, Valipour A Abstract Anaplastic lymphoma kinase (ALK)-translocations are present in up to 5% of non-small cell lung cancer (NSCLC), most of them being adenocarcinomas. Even though the availability...
Wed Sep 02, 2020 14:41
Related Articles Global and regional incidence, mortality and disability-adjusted life-years for Epstein-Barr virus-attributable malignancies, 1990-2017. BMJ Open. 2020 Aug 30;10(8):e037505 Authors: Khan G, Fitzmaurice C, Naghavi M, Ahmed LA Abstract OBJECTIVE: To determine the global and regional burden of Epstein-Barr virus (EBV)-attributed malignancies. DESIGN: An international comparative study based on the Global Burden of Disease...
Wed Sep 02, 2020 14:41
Related Articles Romantic partner involvement during oncology consultations: A narrative review of qualitative and quantitative studies. Patient Educ Couns. 2020 Aug 19;: Authors: Stewart SJ, Roberts L, Brindle L Abstract OBJECTIVE: To review the currently available research into romantic partner involvement during oncology consultations. METHODS: Studies were identified via database searches plus hand-searching. A narrative review...
Wed Sep 02, 2020 14:41
Related Articles The use of radiographic imaging technologies by general dentists in Ontario, Canada. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Aug 14;: Authors: Gillies RC, Quiñonez C, Wood RE, Lam EWN Abstract OBJECTIVE: The aim of this study was to determine the prevalence of 2-dimensional and 3-dimensional digital imaging technologies, the methods used by general dentists to limit patient exposure to ionizing radiation, and the...
Wed Sep 02, 2020 13:44
Related Articles Nobiletin selectively inhibits oral cancer cell growth by promoting apoptosis and DNA damage in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Jul 04;: Authors: Yang J, Yang Y, Wang L, Jin Q, Pan M Abstract OBJECTIVES: The aim of this study was to investigate whether nobiletin (NOB) can inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells by promoting apoptosis, oxidative stress (reactive oxygen...
Wed Sep 02, 2020 13:44
Related Articles Intraneural perineurioma of the mandible: case series of a rare entity. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Jul 21;: Authors: Ko E, McNamara K, Ditty D, Alawi F PMID: 32868253 [PubMed - as supplied by publisher]
Wed Sep 02, 2020 13:44
Related Articles Wandering Spleen Volvulus: A Case Report and Literature Review of This Diagnostic Challenge. Am J Case Rep. 2020 Sep 01;21:e925301 Authors: Koliakos E, Papazarkadas X, Sleiman MJ, Rotas I, Christodoulou M Abstract BACKGROUND Wandering spleen is a rare condition in which the spleen lacks the usual peritoneal attachments, resulting in increased intra-abdominal mobility. Complications can occur due to the torsion of the splenic...
Wed Sep 02, 2020 15:39
Related Articles Alogliptin attenuates cyclophosphamide-induced nephrotoxicity: a novel therapeutic approach through modulating MAP3K/JNK/SMAD3 signaling cascade. Drug Chem Toxicol. 2020 Sep 01;:1-10 Authors: Salama RM, Nasr MM, Abdelhakeem JI, Roshdy OK, ElGamal MA Abstract Cyclophosphamide (CP) is widely used as a chemotherapy against various types of cancers. However, CP is accompanied with multiple organ toxicity due to production of reactive...
Wed Sep 02, 2020 14:45
Related Articles Adrenal schwannoma in a female patient; A rare benign neoplasm: Case report and literature review. Int J Surg Case Rep. 2020 Jul 26;74:173-176 Authors: Jafif Cojab M, Flores Armenta J, Jorge DL, Sanchez Hernandez R, Cervantes Gutierrez O, Brener Chaoul M, Moedano Rico K, Cuevas Bustos R, Perez Tristan FA, Acuña Macouzet A, Gonzalez Woge M, Zamora Duarte LM, Cervantes Millan G, Melendez Sanchez JM, Garcia Mendez AK Abstract INTRODUCTION:...
Wed Sep 02, 2020 15:08
Related Articles Immune checkpoint inhibitor efficacy and safety in older non-small cell lung cancer patients. Jpn J Clin Oncol. 2020 Sep 01;: Authors: Kubo T, Watanabe H, Ninomiya K, Kudo K, Minami D, Murakami E, Ochi N, Ninomiya T, Harada D, Yasugi M, Ichihara E, Ohashi K, Rai K, Fujiwara K, Hotta K, Tabata M, Maeda Y, Kiura K Abstract OBJECTIVES: Immune checkpoint inhibitors offer longer survival than chemotherapy in several clinical trials...
Wed Sep 02, 2020 13:33
Related Articles A phase II study of palliative radiotherapy combined with zoledronic acid hydrate for metastatic bone tumour from renal cell carcinoma. Jpn J Clin Oncol. 2020 Sep 01;: Authors: Harada H, Shikama N, Wada H, Uchida N, Nozaki M, Hayakawa K, Yamada K, Nagakura H, Ogawa H, Miyazawa K, Katagiri H, Nakamura N Abstract PURPOSE: Palliative radiotherapy is the standard of care for bone metastases. However, skeletal-related events, defined...
Wed Sep 02, 2020 13:33
Related Articles The current clinical use of adjuvant analgesics for refractory cancer pain in Japan: a nationwide cross-sectional survey. Jpn J Clin Oncol. 2020 Aug 31;: Authors: Tagami K, Matsuoka H, Ariyoshi K, Oyamada S, Hiratsuka Y, Kizawa Y, Koyama A, Inoue A Abstract BACKGROUND: Although adjuvant analgesics are used to treat opioid-refractory cancer pain, there is insufficient evidence to support this practice and limited data to guide...
Wed Sep 02, 2020 13:33
Related Articles Otolaryngology Residency Interviews in a Socially Distanced World: Strategies to Recruit and Assess Applicants. Otolaryngol Head Neck Surg. 2020 Sep 01;:194599820957961 Authors: Chou DW, Pletcher SD, Bruss D, Sung CK, Diaz RC, Liang J, Durr ML Abstract Due to concerns surrounding travel during the COVID-19 pandemic, the 2020-2021 otolaryngology residency application cycle will be conducted virtually for the first time....
Wed Sep 02, 2020 13:15
Related Articles Recruitment and Networking With Social Media for the Otolaryngology Match in the COVID-19 Pandemic. Otolaryngol Head Neck Surg. 2020 Sep 01;:194599820957952 Authors: Mecham JC, Menapace DC, Bowe SN, Carlson ML Abstract COVID-19 has created new challenges and opportunities regarding the way in which programs and applicants will interact in the 2020-2021 otolaryngology residency match cycle. Social media and other virtual...
Wed Sep 02, 2020 13:15
Related Articles Tracheotomy in a High-Volume Center During the COVID-19 Pandemic: Evaluating the Surgeon's Risk. Otolaryngol Head Neck Surg. 2020 Sep 01;:194599820955174 Authors: Thal AG, Schiff BA, Ahmed Y, Cao A, Mo A, Mehta V, Smith RV, Cohen HW, Ow TJ Abstract OBJECTIVE: Performing tracheotomy in patients with COVID-19 carries a risk of transmission to the surgical team due to potential viral particle aerosolization. Few studies have...
Wed Sep 02, 2020 13:15
Related Articles The Sinonasal Outcome Test-22 or European Position Paper: Which Is More Indicative of Imaging Results? Otolaryngol Head Neck Surg. 2020 Sep 01;:194599820953834 Authors: Zhou AS, Prince AA, Maxfield AZ, Corrales CE, Shin JJ Abstract OBJECTIVE: The 22-item Sinonasal Outcome Test (SNOT-22) is a trusted measure of symptom severity in chronic rhinosinusitis. The European Position Paper on Rhinosinusitis (EPOS) provides widely...
Wed Sep 02, 2020 13:15
Related Articles Establishing an Office-Based Framework for Resuming Otolaryngology Care in Academic Practice During the COVID-19 Pandemic. Otolaryngol Head Neck Surg. 2020 Sep 01;:194599820955178 Authors: Pearlman AN, Tabaee A, Sclafani AP, Sulica L, Selesnick SH, Kutler DI, Montano JJ, Levinger JI, Suurna MV, Modi VK, Stewart MG Abstract OBJECTIVE: The COVID-19 health crisis abruptly disrupted the practice of otolaryngology. This article...
Wed Sep 02, 2020 13:15
Related Articles CARES Act Provider Relief Fund Aid to Otolaryngologists in Small Practices. Otolaryngol Head Neck Surg. 2020 Sep 01;:194599820955183 Authors: Xiao R, Rathi VK Abstract The COVID-19 pandemic has placed unprecedented financial strain on otolaryngologists. Otolaryngologists employed by small practices may be particularly vulnerable to the effects of ongoing losses because these organizations often have limited financial reserves....
Wed Sep 02, 2020 13:15
Related Articles Chemosensory Dysfunction in COVID-19: Prevalences, Recovery Rates, and Clinical Associations on a Large Brazilian Sample. Otolaryngol Head Neck Surg. 2020 Sep 01;:194599820954825 Authors: Brandão Neto D, Fornazieri MA, Dib C, Di Francesco RC, Doty RL, Voegels RL, Pinna FR Abstract OBJECTIVE: Our study aimed to measure the percentage of reported olfactory or taste losses and their severity, recovery time, and association...
Wed Sep 02, 2020 13:15
Related Articles Shared Decision Making for Surgical Care in the Era of COVID-19. Otolaryngol Head Neck Surg. 2020 Sep 01;:194599820954138 Authors: Forner D, Noel CW, Densmore R, Goldstein DP, Corsten M, Pieterse AH, Shuman AG, Hong P, Rac VE Abstract The global pandemic caused by severe acute respiratory syndrome coronavirus 2 has upended surgical practice. In an effort to preserve resources, mitigate risk, and maintain health system capacity,...
Wed Sep 02, 2020 13:15
Related Articles Senescent hepatic stellate cells caused by deoxycholic acid modulates malignant behavior of hepatocellular carcinoma. J Cancer Res Clin Oncol. 2020 Sep 01;: Authors: Nguyen PT, Kanno K, Pham QT, Kikuchi Y, Kakimoto M, Kobayashi T, Otani Y, Kishikawa N, Miyauchi M, Arihiro K, Ito M, Tazuma S Abstract PURPOSE: Deoxycholic acid (DCA), a secondary bile acid, is reportedly increased in the serum of patients with nonalcoholic...
Wed Sep 02, 2020 13:52
Related Articles RACK1 affects the progress of G2/M by regulating Aurora-A. Cell Cycle. 2019 09;18(18):2228-2238 Authors: Shen S, Feng H, Le Y, Ni J, Yu L, Wu J, Bai M Abstract Aurora-A is a serine/threonine kinase, which is overexpressed in multiple human cancers and plays a key role in tumorigenesis and tumor development. In this study, we found that the receptor of activated C-kinase1 (RACK1), an important regulator of biological functions,...
Wed Sep 02, 2020 13:52
Related Articles The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors. Cell Cycle. 2019 09;18(18):2307-2322 Authors: Bahjat M, de Wilde G, van Dam T, Maas C, Bloedjes T, Bende RJ, van Noesel CJM, Luijks DM, Eldering E, Kersten MJ, Guikema JEJ Abstract The BCR-ABL1 fusion gene is the driver oncogene in chronic myeloid leukemia (CML) and Philadelphia-chromosome positive (Ph+)...
Wed Sep 02, 2020 13:52
Related Articles Effects of highly purified cannabidiol (CBD) on fMRI of working memory in treatment-resistant epilepsy. Epilepsy Behav. 2020 Aug 29;112:107358 Authors: Gaston TE, Allendorfer JB, Nair S, Bebin EM, Grayson LP, Martin RC, Szaflarski JP, UAB CBD Program Abstract OBJECTIVE: We aimed to determine changes in working memory and functional connectivity via functional magnetic resonance imaging (fMRI)-modified Sternberg task after treatment...
Wed Sep 02, 2020 14:47
Related Articles Cerebrovascular Disease in Children Perinatally Infected With Human Immunodeficiency Virus in Zambia. Pediatr Neurol. 2020 Aug 05;112:14-21 Authors: Schneider CL, Mohajeri-Moghaddam S, Mbewe EG, Kabundula PP, Dean O, Buda A, Potchen MJ, Mwanza-Kabaghe S, Saylor D, Adams HR, Birbeck GL, Bearden DR Abstract BACKGROUND: High rates of cerebrovascular disease (CVD) have previously been described in pediatric human immunodeficiency...
Wed Sep 02, 2020 14:47
Related Articles Role of Innate Immune Receptor TLR4 and its endogenous ligands in epileptogenesis. Pharmacol Res. 2020 Aug 29;:105172 Authors: Paudel YN, Angelopoulou E, Akyuz E, Piperi C, Othman I, Shaikh MF Abstract Understanding the interplay between the innate immune system, neuroinflammation, and epilepsy might offer a novel perspective in the quest of exploring new treatment strategies. Due to the complex pathology underlying epileptogenesis,...
Wed Sep 02, 2020 14:47
Related Articles Bioequivalence of perampanel fine granules and tablets in healthy Japanese subjects. Int J Clin Pharmacol Ther. 2020 Sep 01;: Authors: Shiba S, Sekino H, Ishiba K, Yasuda S, Inoue S, Kotaka K, Reyderman L, Uchida N Abstract OBJECTIVE: Perampanel is an approved anti-seizure drug. A new formulation of perampanel fine granules (FG; 1% perampanel) has been developed for patients who are unable to take tablets. Bioequivalence between...
Wed Sep 02, 2020 14:47
Related Articles Brain calcification because of neurocysticercosis: a vast field to be explored. Curr Opin Infect Dis. 2020 Aug 29;: Authors: Bustos JA, Coyle CM Abstract PURPOSE OF REVIEW: Neurocysticercosis is the most common helminthic infection of the central nervous system caused by the larval stage of the pork tapeworm, Taenia solium. Endemic regions include Latin American countries, sub-Saharan Africa, and large regions of Asia, including...
Wed Sep 02, 2020 14:47
Related Articles Microglial mTOR is neuronal protective and anti-epileptogenic in the pilocarpine model of temporal lobe epilepsy. J Neurosci. 2020 Aug 31;: Authors: Zhao XF, Liao Y, Alam MM, Mathur R, Feustel P, Mazurkiewicz JE, Adamo MA, Zhu XC, Huang Y Abstract Excessive activation of mTOR signaling is epileptogenic in genetic epilepsy. However, the exact role of microglial mTOR in acquired epilepsy remains to be clarified. In the present...
Wed Sep 02, 2020 14:47
Related Articles Impact of CYP2C19 and CYP2C9 gene polymorphisms on sodium valproate plasma concentration in patients with epilepsy. Eur J Hosp Pharm. 2020 Aug 31;: Authors: Song C, Li X, Mao P, Song W, Liu L, Zhang Y Abstract BACKGROUND: Valproic acid (VPA) is a broad spectrum anticonvulsant drug, which could be partially metabolised by cytochrome P450 (CYP) 2C9 and 2C19 enzymes. This study was designed to investigate the relationship between...
Wed Sep 02, 2020 14:47
Related Articles Management and results of epilepsy surgery associated with acyclovir prophylaxis in four pediatric patients with drug-resistant epilepsy due to herpetic encephalitis and review of the literature. Eur J Paediatr Neurol. 2020 Aug 21;: Authors: Fohlen M, Taussig D, Ferrand-Sorbets S, Maurey H, Petrescu A, Chipaux M, Delalande O, Dorfmuller G Abstract PURPOSE: Herpes simplex virus encephalitis (HSE) is the most common cause of sporadic...
Wed Sep 02, 2020 14:47
Related Articles Targeting Ionotropic Glutamate Receptors In The Treatment Of Epilepsy. Curr Neuropharmacol. 2020 Aug 31;: Authors: Roberta C, Francesco F Abstract BACKGROUND: A dysfunction in glutamate neurotransmission is critical for seizure. Glutamate is the major excitatory drive in the cerebral cortex, where seizures occur. Glutamate acts via (i) ionotropic (iGlu) receptors, which are ligand-gated ion channels mediating fast excitatory...
Wed Sep 02, 2020 14:47
Related Articles Therapeutic Use of the Ketogenic Diet in Refractory Epilepsy: What We Know and What Still Needs to Be Learned. Nutrients. 2020 Aug 27;12(9): Authors: Zarnowska IM Abstract Ketogenic diet (KD) has been used to treat epilepsy for 100 years. It is a high-fat, low-carbohydrate, and sufficient-protein-for-growth diet that mimics the metabolic changes occurring during starvation. Except for classic KD, its modified counterparts, including...
Wed Sep 02, 2020 14:47
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