Antibiotics, Vol. 9, Pages 570: Outpatient Antibiotic Dispensing for the Population with Government Health Insurance in Syria in 2018–2019 Antibiotics doi: 10.3390/antibiotics9090570 Authors: Aljadeeah Wirtz Nagel Little is known about antibiotic uses at the population level in Syria. The aim of our study is to present outpatient antibiotic dispensing (OAD) patterns and rates for patients with health insurance in the parts of Syria that are controlled by the Syrian government...
Wed Sep 02, 2020 03:00
Antibiotics, Vol. 9, Pages 569: Mycogenic Metal Nanoparticles for the Treatment of Mycobacterioses Antibiotics doi: 10.3390/antibiotics9090569 Authors: Marta Filipa Simões Cristiane Angélica Ottoni André Antunes Mycobacterial infections are a resurgent and increasingly relevant problem. Within these, tuberculosis (TB) is particularly worrying as it is one of the top ten causes of death in the world and is the infectious disease that causes the highest number of deaths. A further...
Wed Sep 02, 2020 03:00
Antibiotics, Vol. 9, Pages 568: Antifungal Resistance in Candida auris: Molecular Determinants Antibiotics doi: 10.3390/antibiotics9090568 Authors: María Guadalupe Frías-De-León Rigoberto Hernández-Castro Tania Vite-Garín Roberto Arenas Alexandro Bonifaz Laura Castañón-Olivares Gustavo Acosta-Altamirano Erick Martínez-Herrera Since Candida auris integrates strains resistant to multiple antifungals, research has been conducted focused on knowing which molecular mechanisms...
Wed Sep 02, 2020 03:00
Antibiotics, Vol. 9, Pages 567: Synergy of the Bacteriocin AS-48 and Antibiotics against Uropathogenic Enterococci Antibiotics doi: 10.3390/antibiotics9090567 Authors: Manuel Montalbán-López Rubén Cebrián Rosa Galera Lidia Mingorance Antonio M. Martín-Platero Eva Valdivia Manuel Martínez-Bueno Mercedes Maqueda The genus Enterococcus comprises a ubiquitous group of Gram-positive bacteria that can cause diverse health care-associated infections. Their genome plasticity...
Wed Sep 02, 2020 03:00
Antibiotics, Vol. 9, Pages 566: Activity of Temporin A and Short Lipopeptides Combined with Gentamicin against Biofilm Formed by Staphylococcus aureus and Pseudomonas aeruginosa Antibiotics doi: 10.3390/antibiotics9090566 Authors: Malgorzata Anna Paduszynska Katarzyna Ewa Greber Wojciech Paduszynski Wieslaw Sawicki Wojciech Kamysz The formation of biofilms on biomaterials causes biofilm-associated infections. Available treatments often fail to fight the microorganisms in...
Wed Sep 02, 2020 03:00
Antioxidants, Vol. 9, Pages 817: Transient and Stable Overexpression of Extracellular Superoxide Dismutase Is Positively Associated with the Myogenic Function of Human Skeletal Muscle-Derived Stem/Progenitor Cells Antioxidants doi: 10.3390/antiox9090817 Authors: Nowaczyk Malcher Zimna Łabędź Kubaszewski Fiedorowicz Wierzbiński Rozwadowska Kurpisz In the present study, the genetic modification of human skeletal muscle-derived stem/progenitor cells (SkMDS/PCs)...
Wed Sep 02, 2020 03:00
Antioxidants, Vol. 9, Pages 818: Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease Antioxidants doi: 10.3390/antiox9090818 Authors: D. Allan Butterfield Debra Boyd-Kimball Oxidative and nitrosative stress are widely recognized as critical factors in the pathogenesis and progression of Alzheimer disease (AD) and its earlier stage, amnestic mild cognitive impairment (MCI). A major source of free radicals that lead to oxidative and nitrosative damage is mitochondria....
Wed Sep 02, 2020 03:00
Antioxidants, Vol. 9, Pages 819: Anthocyanins: From the Field to the Antioxidants in the Body Antioxidants doi: 10.3390/antiox9090819 Authors: Vidmantas Bendokas Vidmantas Stanys Ingrida Mažeikienė Sonata Trumbeckaite Rasa Baniene Julius Liobikas Anthocyanins are biologically active water-soluble plant pigments that are responsible for blue, purple, and red colors in various plant parts—especially in fruits and blooms. Anthocyanins have attracted attention as...
Wed Sep 02, 2020 03:00
Antioxidants, Vol. 9, Pages 816: Aronia melanocarpa Fruit Bioactive Fraction Attenuates LPS-Induced Inflammatory Response in Human Bronchial Epithelial Cells Antioxidants doi: 10.3390/antiox9090816 Authors: Jang Lee Choi Yim To demonstrate the anti-inflammatory activity of Aronia melanocarpa fruit extract, human bronchial epithelial cells (BEAS-2B) were treated with lipopolysaccharide (LPS) and the effects of aronia bioactive fraction (ABF®), anthocyanin enriched...
Wed Sep 02, 2020 03:00
Atmosphere, Vol. 11, Pages 938: Sustainable Development of the Historic Centre of Naples: The Impact of Vehicular Traffic and Food Service Business on Air Quality Atmosphere doi: 10.3390/atmos11090938 Authors: Murena Monitoring campaigns were carried out to assess the impact of vehicular traffic and food service business on the air quality in the historic centre of Naples. These campaigns monitored fine particles (FPs) from 20 to 1000 nm, using a condensation particle counter (CPC)...
Wed Sep 02, 2020 03:00
Atmosphere, Vol. 11, Pages 939: Evaluation of Rainfall Forecasts by Three Mesoscale Models during the Mei-yu Season of 2008 in Taiwan. Part II: Development of An Object-Oriented Method Atmosphere doi: 10.3390/atmos11090939 Authors: Wang Paul Lee This study describes a recently developed object-oriented method suitable for Taiwan for the purpose to verify quantitative precipitation forecasts (QPFs) produced by mesoscale models as a complement to the traditional approaches in...
Wed Sep 02, 2020 03:00
Atmosphere, Vol. 11, Pages 937: Snow Impurities in the Central Pyrenees: From Their Geochemical and Mineralogical Composition towards Their Impacts on Snow Albedo Atmosphere doi: 10.3390/atmos11090937 Authors: Jorge Pey Jesús Revuelto Natalia Moreno Esteban Alonso-González Miguel Bartolomé Jesús Reyes Simon Gascoin Juan Ignacio López-Moreno The aim of this work is to understand aerosol transfers to the snowpack in the Spanish Pyrenees (Southern Europe) by determining...
Wed Sep 02, 2020 03:00
Bioengineering, Vol. 7, Pages 104: Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering Bioengineering doi: 10.3390/bioengineering7030104 Authors: Pasquale Marrazzo Cian O’Leary Although a large panel of natural antioxidants demonstrate a protective effect in preventing cellular oxidative stress, their low bioavailability limits therapeutic activity at the targeted injury site. The importance to deliver drug or cells into oxidative microenvironments...
Wed Sep 02, 2020 03:00
Biology, Vol. 9, Pages 265: 5-Fluorouracil Conversion Pathway Mutations in Gastric Cancer Biology doi: 10.3390/biology9090265 Authors: Alessio Biagioni Fabio Staderini Sara Peri Giampaolo Versienti Nicola Schiavone Fabio Cianchi Laura Papucci Lucia Magnelli To date, 5-Fluorouracil (5FU) is a major component of several chemotherapy regimens, thus its study is of fundamental importance to better understand all the causes that may lead to chemoresistance and treatment...
Wed Sep 02, 2020 03:00
Biology, Vol. 9, Pages 264: An Experimentally Defined Hypoxia Gene Signature in Glioblastoma and Its Modulation by Metformin Biology doi: 10.3390/biology9090264 Authors: Marta Calvo Tardón Eliana Marinari Denis Migliorini Viviane Bes Stoyan Tankov Emily Charrier Thomas A McKee Valérie Dutoit Pierre-Yves Dietrich Erika Cosset Paul R Walker Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor, characterized by a high degree of...
Wed Sep 02, 2020 03:00
Biomedicines, Vol. 8, Pages 325: Clinical Aspects and Current Therapeutic Approaches for FOP Biomedicines doi: 10.3390/biomedicines8090325 Authors: Hiroshi Kitoh Fibrodysplasia ossificans progressiva (FOP) is an extremely rare heritable disorder of connective tissues characterized by progressive heterotopic ossification in various skeletal sites. It is caused by gain-of-function mutations in the gene encoding activin A receptor type I (ACVR1)/activin-like kinase 2 (ALK2), a bone morphogenetic...
Wed Sep 02, 2020 03:00
Biomedicines, Vol. 8, Pages 324: The Role of Satellite Glial Cells, Astrocytes, and Microglia in Oxaliplatin-Induced Neuropathic Pain Biomedicines doi: 10.3390/biomedicines8090324 Authors: Ji Hwan Lee Woojin Kim Oxaliplatin is a third-generation platinum-based chemotherapeutic drug. Although its efficacy against colorectal cancer is well known, peripheral neuropathy that develops during and after infusion of the agents could decrease the quality of life of the patients. Various pathways...
Wed Sep 02, 2020 03:00
Biomimetics, Vol. 5, Pages 43: Fabrication and Characterization of Polylactic Acid Electrospun Scaffolds Modified with Multi-Walled Carbon Nanotubes and Hydroxyapatite Nanoparticles Biomimetics doi: 10.3390/biomimetics5030043 Authors: Athanasios Kotrotsos Prokopis Yiallouros Vassilis Kostopoulos The solution electrospinning process (SEP) is a cost-effective technique in which a wide range of polymeric materials can be electrospun. Electrospun materials can also be easily modified...
Wed Sep 02, 2020 03:00
Biomimetics, Vol. 5, Pages 42: Three-Dimensional Printed Antimicrobial Objects of Polylactic Acid (PLA)-Silver Nanoparticle Nanocomposite Filaments Produced by an In-Situ Reduction Reactive Melt Mixing Process Biomimetics doi: 10.3390/biomimetics5030042 Authors: Nectarios Vidakis Markos Petousis Emmanouel Velidakis Marco Liebscher Lazaros Tzounis In this study, an industrially scalable method is reported for the fabrication of polylactic acid (PLA)/silver nanoparticle (AgNP)...
Wed Sep 02, 2020 03:00
Biomolecules, Vol. 10, Pages 1268: Flavonoid Nanoparticles: A Promising Approach for Cancer Therapy Biomolecules doi: 10.3390/biom10091268 Authors: Malgorzata Dobrzynska Marta Napierala Ewa Florek Flavonoids, a ubiquitous group of naturally occurring polyphenolic compounds, have recently gained importance as anticancer agents. Unfortunately, due to low solubility, absorption, and rapid metabolism of dietary flavonoids, their anticancer potential is not sufficient. Nanocarriers...
Wed Sep 02, 2020 03:00
Biomolecules, Vol. 10, Pages 1266: Targeting MHC Regulation Using Polycyclic Polyprenylated Acylphloroglucinols Isolated from Garcinia bancana Biomolecules doi: 10.3390/biom10091266 Authors: Chloé Coste Nathalie Gérard Chau Phi Dinh Antoine Bruguière Caroline Rouger Sow Tein Leong Khalijah Awang Pascal Richomme Séverine Derbré Béatrice Charreau Modulation of major histocompatibility complex (MHC) expression using drugs has been proposed to control immunity....
Wed Sep 02, 2020 03:00
Biomolecules, Vol. 10, Pages 1267: The Antimicrobial Cathelicidin CRAMP Augments Platelet Activation during Psoriasis in Mice Biomolecules doi: 10.3390/biom10091267 Authors: Maryam F. Salamah Thomas M. Vallance Xenia Kodji Divyashree Ravishankar Harry F. Williams Susan D. Brain Sakthivel Vaiyapuri Platelet-associated complications including thrombosis, thrombocytopenia, and haemorrhage are commonly observed during various inflammatory diseases such as psoriasis. Although...
Wed Sep 02, 2020 03:00
Biomolecules, Vol. 10, Pages 1264: Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels Biomolecules doi: 10.3390/biom10091264 Authors: Qian Jiang Andrew M. Peterson Yuyang Chu Xiaolan Yao Xiang-ming Zha Xiang-Ping Chu Acid-sensing ion channel (ASIC) subunits 1a and 3 are highly expressed in central and peripheral sensory neurons, respectively. Endogenous biomolecule zinc plays a critical role in physiological...
Wed Sep 02, 2020 03:00
Biomolecules, Vol. 10, Pages 1265: 8-Deoxy-Rifamycin Derivatives from Amycolatopsis mediterranei S699 ΔrifT Strain Biomolecules doi: 10.3390/biom10091265 Authors: Feng Ye Yanrong Shi Shengliang Zhao Zhiying Li Haoxin Wang Chunhua Lu Yuemao Shen Proansamycin X, a hypothetical earliest macrocyclic precursor in the biosynthesis of rifamycin, had never been isolated and identified. According to bioinformatics analysis, it was proposed that RifT (a putative NADH-dependent...
Wed Sep 02, 2020 03:00
Biomolecules, Vol. 10, Pages 1263: Lipid Phosphate Phosphatases and Cancer Biomolecules doi: 10.3390/biom10091263 Authors: Xiaoyun Tang David N. Brindley Lipid phosphate phosphatases (LPPs) are a group of three enzymes (LPP1–3) that belong to a phospholipid phosphatase (PLPP) family. The LPPs dephosphorylate a wide spectrum of bioactive lipid phosphates, among which lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P) are two important extracellular signaling molecules....
Wed Sep 02, 2020 03:00
Brain Sciences, Vol. 10, Pages 603: Partial Similarity Reveals Dynamics in Brainstem-Midbrain Networks during Trigeminal Nociception Brain Sciences doi: 10.3390/brainsci10090603 Authors: Arne May Laura Helene Schulte Guido Nolte Jan Mehnert Imaging studies help us understand the important role of brainstem and midbrain regions in human trigeminal pain processing without solving the question of how these regions actually interact. In the current study, we describe this connectivity...
Wed Sep 02, 2020 03:00
Brain Sciences, Vol. 10, Pages 602: Study on Representation Invariances of CNNs and Human Visual Information Processing Based on Data Augmentation Brain Sciences doi: 10.3390/brainsci10090602 Authors: Yibo Cui Chi Zhang Kai Qiao Linyuan Wang Bin Yan Li Tong Representation invariance plays a significant role in the performance of deep convolutional neural networks (CNNs) and human visual information processing in various complicated image-based tasks. However, there has...
Wed Sep 02, 2020 03:00
Brain Sciences, Vol. 10, Pages 601: Investigating Gait, Movement, and Coordination in Children with Neurodevelopmental Disorders: Is There a Role for Motor Abnormalities in Atypical Neurodevelopment? Brain Sciences doi: 10.3390/brainsci10090601 Authors: Marco Colizzi Marco Luigi Ciceri Gianfranco Di Gennaro Beatrice Morari Alessandra Inglese Marialuisa Gandolfi Nicola Smania Leonardo Zoccante Motor abnormalities have been suggested to play a role in most neuropsychiatric...
Wed Sep 02, 2020 03:00
Cancers, Vol. 12, Pages 2490: Single-Cell NGS-Based Analysis of Copy Number Alterations Reveals New Insights in Circulating Tumor Cells Persistence in Early-Stage Breast Cancer Cancers doi: 10.3390/cancers12092490 Authors: Tania Rossi Giulia Gallerani Davide Angeli Claudia Cocchi Erika Bandini Pietro Fici Michele Gaudio Giovanni Martinelli Andrea Rocca Roberta Maltoni Francesco Fabbri Circulating tumor cells (CTCs) are a rare population of cells representing...
Wed Sep 02, 2020 03:00
Cancers, Vol. 12, Pages 2488: Circulating miRNA Increases the Diagnostic Accuracy of Chromogranin A in Metastatic Pancreatic Neuroendocrine Tumors Cancers doi: 10.3390/cancers12092488 Authors: Annamária Kövesdi Petra Anna Kurucz Gábor Nyírő Ottó Darvasi Attila Patócs Henriett Butz Chromogranin A (CgA) is the most widely accepted biomarker for neuroendocrine tumors (NET) but its diagnostic accuracy is dependent on tumor type and the use of proton-pump inhibitors (PPI)....
Wed Sep 02, 2020 03:00
Cancers, Vol. 12, Pages 2489: lncRNAs–mRNAs Co–Expression Network Underlying Childhood B–Cell Acute Lymphoblastic Leukaemia: A Pilot Study Cancers doi: 10.3390/cancers12092489 Authors: Ornella Affinito Katia Pane Giovanni Smaldone Francesca Maria Orlandella Peppino Mirabelli Giuliana Beneduce Rosanna Parasole Mimmo Ripaldi Marco Salvatore Monica Franzese Long non–coding RNAs (lncRNAs) are emerging as key gene regulators in the pathogenesis and development...
Wed Sep 02, 2020 03:00
Cancers, Vol. 12, Pages 2487: Patient-Reported Outcome Measures in Pancreatic Cancer Receiving Radiotherapy Cancers doi: 10.3390/cancers12092487 Authors: Ramez Kouzy Joseph Abi Jaoude Daniel Lin Nicholas D. Nguyen Molly B. El Alam Ethan B. Ludmir Cullen M. Taniguchi Pancreatic cancer and its treatment often dramatically impact patients’ quality of life (QoL). Given this, as well as increased focus on QoL measures in clinical oncology, there has been a rise in the number...
Wed Sep 02, 2020 03:00
Cancers, Vol. 12, Pages 2486: mTOR Modulates Intercellular Signals for Enlargement and Infiltration in Glioblastoma Multiforme Cancers doi: 10.3390/cancers12092486 Authors: Larisa Ryskalin Francesca Biagioni Paola Lenzi Alessandro Frati Francesco Fornai Recently, exosomal release has been related to the acquisition of a malignant phenotype in glioblastoma cancer stem cells (GSCs). Remarkably, intriguing reports demonstrate that GSC-derived extracellular vesicles (EVs) contribute...
Wed Sep 02, 2020 03:00
Cancers, Vol. 12, Pages 2485: Robotic-Assisted Colonoscopy Platform with a Magnetically-Actuated Soft-Tethered Capsule Cancers doi: 10.3390/cancers12092485 Authors: Mauro Verra Andrea Firrincieli Marcello Chiurazzi Andrea Mariani Giacomo Lo Secco Edoardo Forcignanò Anastasios Koulaouzidis Arianna Menciassi Paolo Dario Gastone Ciuti Alberto Arezzo Background and Aims: Colorectal cancer (CRC) is a major cause of morbidity and mortality worldwide. Despite offering...
Wed Sep 02, 2020 03:00
Cells, Vol. 9, Pages 2025: The Roles of Ubiquitin in Mediating Autophagy Cells doi: 10.3390/cells9092025 Authors: Zhangyuan Yin Hana Popelka Yuchen Lei Ying Yang Daniel J. Klionsky Ubiquitination, the post-translational modification essential for various intracellular processes, is implicated in multiple aspects of autophagy, the major lysosome/vacuole-dependent degradation pathway. The autophagy machinery adopted the structural architecture of ubiquitin and employs two ubiquitin-like...
Wed Sep 02, 2020 03:00
Cells, Vol. 9, Pages 2026: Chemical Genetics Approach Identifies Abnormal Inflorescence Meristem 1 as a Putative Target of a Novel Sulfonamide That Protects Catalase2-Deficient Arabidopsis against Photorespiratory Stress Cells doi: 10.3390/cells9092026 Authors: Tom van der Meer Arno Verlee Patrick Willems Francis Impens Kris Gevaert Christa Testerink Christian V. Stevens Frank Van Breusegem Pavel Kerchev Alterations of hydrogen peroxide (H2O2) levels have a profound...
Wed Sep 02, 2020 03:00
Cells, Vol. 9, Pages 2020: Heat Shock Protein 70 (HSP70) Induction: Chaperonotherapy for Neuroprotection after Brain Injury Cells doi: 10.3390/cells9092020 Authors: Jong Youl Kim Sumit Barua Mei Ying Huang Joohyun Park Midori A. Yenari Jong Eun Lee The 70 kDa heat shock protein (HSP70) is a stress-inducible protein that has been shown to protect the brain from various nervous system injuries. It allows cells to withstand potentially lethal insults through its chaperone...
Wed Sep 02, 2020 03:00
Cells, Vol. 9, Pages 2021: Novel Opportunities for Cathepsin S Inhibitors in Cancer Immunotherapy by Nanocarrier-Mediated Delivery Cells doi: 10.3390/cells9092021 Authors: Natalie Fuchs Mergim Meta Detlef Schuppan Lutz Nuhn Tanja Schirmeister Cathepsin S (CatS) is a secreted cysteine protease that cleaves certain extracellular matrix proteins, regulates antigen presentation in antigen-presenting cells (APC), and promotes M2-type macrophage and dendritic cell polarization....
Wed Sep 02, 2020 03:00
Cells, Vol. 9, Pages 2023: Intracellular Trafficking of HBV Particles Cells doi: 10.3390/cells9092023 Authors: Bingfu Jiang Eberhard Hildt The human hepatitis B virus (HBV), that is causative for more than 240 million cases of chronic liver inflammation (hepatitis), is an enveloped virus with a partially double-stranded DNA genome. After virion uptake by receptor-mediated endocytosis, the viral nucleocapsid is transported towards the nuclear pore complex. In the nuclear basket, the...
Wed Sep 02, 2020 03:00
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