Abstract Background Thyroid carcinoma (THCA) is the most prevalent tumor in the endocrine system with an increasing incidence. Recent studies have underscored the function of microRNAs (miRNAs) in THCA. Nevertheless, knowledge regarding the effects of exosomal miRNAs in THCA is still limited. This report intended to probe the regulatory effects of exosomal miR-152 on THCA and the underlying mechanism. ...
Wed Sep 02, 2020 03:00
Abstract Background Binding of thyroglobulin (Tg) to heparin is involved in Tg transcytosis via megalin. Rat Tg (rTg) binds to heparin through an exposed carboxyl terminal region (RELPSRRLKRPLPVK, Arg2489-Lys2503) rich in positively charged residues. This region is not entirely conserved in human Tg (hTg) (Arg2489-Glu2503, REPPARALKRSLWVE), resulting in lower affinity binding. Here, we developed a score to predict to what extent secondary...
Wed Sep 02, 2020 03:00
Abstract Objective We compared demographic and clinic-pathological variables related to the number of surgeries for thyroid conditions or for cancer, morbidity, and fine needle aspiration (FNA) practices among Covid19 pandemic phases I, II, III and the same seasonal periods in 2019. Methods The prospective database of the Division of Thyroid Surgery,...
Wed Sep 02, 2020 03:00
Publication date: Available online 2 September 2020Source: Revue des Maladies RespiratoiresAuthor(s): O. Georges, K. Risso, V. Lemiale, F. Schlemmer
Wed Sep 02, 2020 15:02
Publication date: Available online 1 September 2020Source: Revue des Maladies RespiratoiresAuthor(s): M. Tran Luy, A.-L. Le Faou, G. Airagnes, F. Limosin
Wed Sep 02, 2020 15:02
Publication date: Available online 1 September 2020Source: Revue des Maladies RespiratoiresAuthor(s): M. Plion, J.-C. Dalphin, T. Soumagne
Wed Sep 02, 2020 15:02
Related Articles HPVomics: An integrated resource for the human papillomavirus epitome and therapeutics. Genomics. 2020 Aug 29;: Authors: Gupta AK, Kumar M Abstract Human papillomaviruses (HPVs) belongs to the Papillomaviridae family, which is divided into high-risk (HR), and low-risk (LR) HPVs based on their disease-causing competence. HR-HPVs 16 and 18 are known to cause distinct carcinomas like cervical and head and neck, whereas LR-HPVs...
Wed Sep 02, 2020 14:53
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundStandard dapsone and clofazimine-containing multidrug therapy (MDT) for leprosy is limited by drug tolerability, which poses treatment adherence barriers. Although ofloxacin-based regimens are promising alternatives, current efficacy and safety data are limited, particularly outside of endemic areas. We evaluated treatment outcomes in patients with leprosy receiving ofloxacin-containing MDT (OMDT) at our center.MethodsWe performed...
Tue Sep 01, 2020 14:03
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Biologic drugs are increasingly being prescribed for the treatment of psoriasis. Very little information is available in the literature regarding potential drug interactions with these medications. This paper serves as a guide for prescribers to be aware of possible interactions between biologic drugs approved for the treatment of psoriasis in North America and concomitant therapies.ObjectiveTo provide an overview of reported drug interactions...
Tue Sep 01, 2020 06:16
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundThe systemic effects and comorbidities of psoriasis include ocular disorders, such as uveitis. Patients with psoriatic arthritis in particular have been demonstrated to have an elevated risk for developing uveitis. Presently, the risk of uveitis in psoriasis has yet to be fully elucidated and this systematic review seeks to address this gap.ObjectiveTo examine the prevalence and incidence of uveitis in psoriasis patients compared...
Mon Aug 31, 2020 09:49
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Mon Aug 10, 2020 07:50
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Coronavirus disease (COVID-19), a respiratory disease caused by a novel coronavirus designated severe acute respiratory syndrome coronavirus 2, has rapidly spread worldwide and has been recognized as a pandemic by the World Health Organization. Patients with altered immunologic function are at higher risk of acquiring COVID-19. In patients with psoriasis, inhibition of select pro-inflammatory cytokines through the use of biologic agents has...
Thu Aug 06, 2020 15:17
Skin Damage Prevention Strategies During COVID-19: Assessing Their Effect on N95 Mask Seal Integrity
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Wed Aug 05, 2020 09:54
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Deoxycholic acid (BELKYRATM, Allergan, Markham, ON, Canada) is a minimally invasive injectable treatment approved by Health Canada for the nonsurgical reduction of submental fullness. Multiple phase III clinical trials have proven the efficacy and safety of deoxycholic acid. In the clinical trials, the most common adverse events (AEs) reported, such as injection site pain, numbness, swelling, bruising and induration, were transient and mild-to-moderate...
Wed Aug 05, 2020 08:33
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Immune checkpoint inhibitors have proven to be efficacious for a broad spectrum of solid organ malignancies. These monoclonal antibodies lead to cytotoxic T-cell activation and subsequent elimination of cancer cells. However, they can also lead to immune intolerance and immune-related adverse event (irAEs) that are new and specific to these therapies. Cutaneous irAEs are the most common, arising in up to 34% of patients on PD-1 inhibitors...
Tue Aug 04, 2020 08:41
Background: Speech-in-speech recognition scores tend to be more variable than the speech-in-noise recognition scores, both within and across listeners. This variability could be due to listener factors, such as individual differences in audibility or susceptibility to informational masking. It could also be due to stimulus variability, with some speech-in-speech samples posing more of a challenge than others. The purpose of this experiment was to test two hypotheses: (1) that stimulus variability...
Mon Aug 31, 2020 03:00
Publication date: Available online 2 September 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Adam Ostrzenski
Wed Sep 02, 2020 14:13
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background/Aim:Lymph node density is a parameter used to more accurately predict tumor recurrence and patient survival. However, its association with surgical outcome in pyriform sinus carcinoma remains unclear. The purpose of this study was to assess the prognostic value of lymph node density in advanced pyriform sinus carcinoma.Patients and Methods:A total of 87 patients with pyriform sinus carcinoma treated...
Wed Sep 02, 2020 12:29
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. As a malignant hematopoietic stem cell disease, leukemia remains life-threatening due to its increasing incidence rate and mortality rate. Therefore, its early diagnosis and treatment play a very important role. In the present work, we systematically reviewed the current applications and future directions of positron emission tomography (PET) in patients with leukemia, especially 18F-FDG PET/CT. As a useful imaging...
Wed Sep 02, 2020 12:09
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Cancer stem cells, a special subgroup of cancer cells, have self-renewal capabilities and multidirectional potential, which may be reprogrammed from the dedifferentiation of cancer cells, contributing to the failure of clinical treatments. Esophageal adenocarcinoma grows in an inflammatory environment stimulated by deoxycholic acid, an important component of gastroesophageal reflux content, contributing to the...
Tue Sep 01, 2020 13:01
Publication date: Available online 2 September 2020Source: Magnetic Resonance ImagingAuthor(s): Sébastien Levilly, Marco Castagna, Jérôme Idier, Félicien Bonnefoy, David Le Touzé, Perrine Paul-Gilloteaux, Saïd Moussaoui, Jean-Michel Serfaty
Wed Sep 02, 2020 13:55
Publication date: Available online 2 September 2020Source: Magnetic Resonance ImagingAuthor(s): Michael Z. Liu, Simukayi Mutasa, Peter Chang, Maham Siddique, Sachin Jambawalikar, Richard Ha
Wed Sep 02, 2020 13:55
Publication date: Available online 1 September 2020Source: Magnetic Resonance ImagingAuthor(s): Zhiyang Fu, Sagar Mandava, Mahesh B. Keerthivasan, Zhitao Li, Kevin Johnson, Diego R. Martin, Maria I. Altbach, Ali Bilgin
Wed Sep 02, 2020 13:55
Related Articles Effect of TRP-Stimulating Compounds to Reduce Swallowing Response Time in the Elderly: A Systematic Review. Dysphagia. 2020 Aug 31;: Authors: Kittipanya-Ngam P, Benjapornlert P, Rattanakanokchai S, Wattanapan P Abstract There is still controversy on evidence supporting compounds that stimulate the transient receptor potential cation channel (TRP) receptor, which can reduce the latency of swallowing reflex. This systematic review...
Wed Sep 02, 2020 13:47
Related Articles How COVID-19 Patients Were Moved to Speak: A Rehabilitation Interdisciplinary Case Series. HSS J. 2020 Aug 26;:1-8 Authors: Mooney B, Lawrence C, Johnson EG, Slaboden A, Ball K Abstract Background: Up to 36% of patients admitted to the ICU for COVID-19 require tracheostomy. While the literature recommends the use of multidisciplinary teams in the management of patients with tracheostomy for other diseases, little is known on...
Wed Sep 02, 2020 13:47
Publication date: Available online 2 September 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Sandra C.P. Jansen, Lambertus P.J. van Nistelrooij, Marc R.M. Scheltinga, Ellen V. Rouwet, Joep A.W. Teijink, Anco C. Vahl
Wed Sep 02, 2020 13:36
Publication date: Available online 1 September 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Iris Naudin, Nellie Della-Schiava
Wed Sep 02, 2020 13:36
Publication date: Available online 1 September 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Aurélien Hostalrich, Jean Porterie, Jean Segal, Benoit Lebas, Lauranne Matray, Thimothée Abaziou, Jean-Baptiste Ricco, Xavier Chaufour
Wed Sep 02, 2020 13:36
Related Articles The Oral Microbiota May Have Influence on Oral Cancer. Front Cell Infect Microbiol. 2019;9:476 Authors: Zhang L, Liu Y, Zheng HJ, Zhang CP Abstract The oral microbiota plays an important role in the human microbiome and human health, and imbalances between microbes and their hosts can lead to oral and systemic diseases and chronic inflammation, which is usually caused by bacteria and contributes to cancer. There may be a relationship...
Wed Sep 02, 2020 13:25
Related Articles How Should We Determine the Value of CAR T-Cell Therapy? AMA J Ethics. 2019 10 01;21(10):E844-851 Authors: Silbert S, Yanik GA, Shuman AG Abstract In 2017, the US Food and Drug Administration approved the first chimeric antigen receptor (CAR) T-cell therapies for patients with relapsed or refractory B-cell leukemia and selected B-cell lymphomas. This novel form of cellular immunotherapy creates a "living drug" that effectively...
Wed Sep 02, 2020 13:25
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Abhinav Karan, Kabeer Ali, Kirin Rambaran, Pedro Del Corral, Sateesh Sakhamuri, Surujpal Teelucksingh
Wed Sep 02, 2020 13:24
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): George D. Vavougios
Wed Sep 02, 2020 13:24
Signia announced the start of the Styletto X Challenge, a hearing aid giveaway program that will run from Aug 31 until the end of 2020. Participants can enter to win one of 10 pairs of Signia's Styletto X hearwear™, which features improved audibility for speech in noise and advanced features created in response to Covid-19."Signia's premium hearing aids like Styletto X do more than just improve how people hear; they empower wearers to live life to the fullest by connecting with those around them,"...
Mon Aug 31, 2020 19:59
Publication date: Available online 2 September 2020Source: American Journal of Infection ControlAuthor(s): Danielle J Durant
Wed Sep 02, 2020 13:03
Publication date: October 2020Source: Journal of Human Evolution, Volume 147Author(s): Matteo Romandini, Gregorio Oxilia, Eugenio Bortolini, Stéphane Peyrégne, Davide Delpiano, Alessia Nava, Daniele Panetta, Giovanni Di Domenico, Petra Martini, Simona Arrighi, Federica Badino, Carla Figus, Federico Lugli, Giulia Marciani, Sara Silvestrini, Jessica C. Menghi Sartorio, Gabriele Terlato, Jean-Jacques Hublin, Matthias Meyer, Luca Bondioli
Wed Sep 02, 2020 13:02
Publication date: 15 January 2021Source: Talanta, Volume 222Author(s): Fuentes-Vélez Susana, Fagoonee Sharmila, Sanginario Alessandro, Gallo Valentina, Riganti Chiara, Pizzi Marco, Altruda Fiorella, Demarchi Danilo
Wed Sep 02, 2020 13:00
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