Background Acinic cell carcinoma (AcCC) is diagnostically challenging on fine‐needle aspiration because it can mimic several other neoplasms or even normal acinar tissue. Immunopositivity for DOG1, especially circumferential membranous staining, can support the diagnosis of AcCC but is not entirely specific, and it is prone to technical and interpretive challenges on small specimens. NR4A3 (nuclear receptor subfamily 4 group A member 3) translocation and nuclear NR4A3 overexpression were recently...
Tue Aug 18, 2020 17:20
Background The International System for Reporting Serous Fluid Cytopathology was recently proposed as a tiered structure to provide consistent reporting terminology for serous effusions. Because of the variation in reporting practices for indeterminate serous effusions, namely, the atypia of undetermined significance (AUS) and suspicious for malignancy (SFM) groups, the authors retrospectively reviewed cases in these 2 categories at their institution and determined the associated risk of malignancy...
Tue Aug 18, 2020 17:19
Abstract Research within the anatomical sciences often relies on human cadaveric tissues. Without the good will of these donors who allow us to use their bodies to push forward our anatomical knowledge, most human anatomical research would come to a standstill. However, many research papers omit an acknowledgement to the donor cadavers or, as no current standardized versions exist, use language that is extremely varied. To remedy this problem, 19 editors‐in‐chiefs from 16 anatomical journals joined...
Tue Aug 18, 2020 12:09
Zusammenfassung Zahlreiche unterschiedliche Substanzen wie Medikamente, Heilkräuter, Nahrungsergänzungsmittel können einen toxischen Leberparenchymschaden induzieren im Sinne einer klinisch relevanten Komplikation. Die Drug-Induced Liver Injury (DILI), welche auf einem direkt toxischen oder idiosynkratischen Mechanismus beruht, kann ein breites Spektrum klinischer Erscheinungen zeigen mit isolierten Leberwerterhöhungen bis zum akuten Leberversagen. Die Kategorisierung des Schadens...
Wed Aug 19, 2020 03:00
Abstract Background Renal cell carcinoma (RCC) constitutes 3% of all cancers, with a higher incidence in patients with age between 60 and 70 years. RCC frequently present as a metastatic tumor at diagnosis, and bones represent one of the most frequent sites. Many cases, mainly in young patients, includes the Xp11 translocation RCC. The cytological diagnosis of Xp11 translocation RCC in adult population it is rarely performed, likely for the morphological overlap with other adult renal cell carcinoma...
Tue Aug 18, 2020 17:44
Abstract Objectives Adenoid cystic carcinoma (ACCA) is an uncommon primary malignancy of salivary glands and rarely nonsalivary tissue. This study aims to evaluate the diagnostic accuracy of ACCA on fine needle aspiration (FNA) material and the associated challenges. Methods A search on electronic pathology database from 2006 to 2016 at The Johns Hopkins Hospital found 83 cytology specimens diagnosed as ACCA, 49 with histology follow‐up. Results Fifty‐two females and 31 males were...
Tue Aug 18, 2020 17:42
Abstract The traditional approach to the diagnosis of primary adenohypophyseal cell proliferations uses hormone immunohistochemistry to classify pituitary neuroendocrine tumors (PitNETs). The routine application of immunolocalization of pituitary transcription factors (SF1, PIT1, TPIT, ERα, and recently GATA3) along with adenohypophyseal hormones has taught us critical lessons that are discussed in this communication. We point out that appropriate patient care requires accurate...
Wed Aug 19, 2020 03:00
Abstract Neuroendocrine neoplasms (NENs) have traditionally been identified via expression of proteins associated to the regulation of secretory vesicles and granules. We report the clinical usage of the “second-generation” proteins ISL LIM homeobox 1 (ISL1), INSM transcriptional repressor 1 (INSM1), and secretagogin (SECG) as immunohistochemical markers of neuroendocrine differentiation since their introduction in clinical routine and compare the results with the established...
Wed Aug 19, 2020 03:00
Here, we employ two methods of reconstructing locomotor agility from the semicircular canals (SCCs) of fossil rodents: radius of curvature dimensions and SCC orthogonality. Radius of curvature dimensions provide compelling evidence that arboreality was likely an ancestral trait for the Sciuroidea clade and that early aplodontids were more arboreal than their burrowing descendants. Abstract Reconstructing locomotor behaviour for fossil animals is typically done with postcranial elements. However,...
Wed Aug 19, 2020 11:20
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