Background Ligation of glucocorticoid‐induced tumor necrosis factor receptor (GITR) decreases regulatory T cell–mediated suppression and enhances T‐cell proliferation, effector function, and survival. MK‐1248 is a humanized immunoglobulin G4 anti‐GITR monoclonal antibody agonist. Methods In patients with advanced solid tumors, MK‐1248 (starting dose, 0.12 mg) was tested alone and with pembrolizumab (200 mg) according to a 3 + 3 dose escalation design (ClinicalTrials.gov identifier NCT02553499);...
Tue Aug 18, 2020 17:24
Background Progress in the treatment of juvenile cancers has led to remarkable improvements in survival. However, not all families have the resources to cope with the burden that such diseases require. This study was aimed at evaluating the association between parental education and cancer mortality in children, adolescents, and young adults. Methods This was a case‐cohort study based on 1889 cancer cases and 108,387 noncases sampled from the 2011 Italian census cohort of 10,964,837 individuals...
Tue Aug 18, 2020 17:21
Background For women with ovarian cancer (OC), the optimal screening strategy to identify Lynch syndrome (LS) has not been determined. In the current study, the authors compared the performance characteristics of various strategies combining mismatch repair (MMR) immunohistochemistry (IHC), microsatellite instability testing (MSI), and family history for the detection of LS. Methods Women with nonserous and/or nonmucinous ovarian cancer were recruited prospectively from 3 cancer centers in...
Tue Aug 18, 2020 17:20
Background Data on drug‐induced liver injury (DILI) and acute liver failure (ALF) in modern phase 1 oncology trials are limited, specifically with respect to the incidence and resolution of DILI and the safety of drug rechallenge. Methods This study reviewed all patients who were recruited to phase 1 oncology trials between 2013 and 2017 at Memorial Sloan Kettering Cancer Center. Clinicopathologic data were extracted to characterize DILI, and attribution was assessed on the basis of data prospectively...
Tue Aug 18, 2020 17:19
Background Novel therapies are urgently needed for pediatric patients with relapsed acute myeloid leukemia (AML). Methods To determine whether the histone deacetylase inhibitor panobinostat could be safely given in combination with intensive chemotherapy, a phase 1 trial was performed in which 17 pediatric patients with relapsed or refractory AML received panobinostat (10, 15, or 20 mg/m2) before and in combination with fludarabine and cytarabine. Results All dose levels were tolerated,...
Tue Aug 18, 2020 17:19
British Journal of Cancer, Published online: 20 August 2020; doi:10.1038/s41416-020-01032-yE2F7−EZH2 axis regulates PTEN/AKT/mTOR signalling and glioblastoma progression
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British Journal of Cancer, Published online: 20 August 2020; doi:10.1038/s41416-020-1019-zLet the question determine the methods: descriptive epidemiology done right
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Abstract Because of the complexity of cancer‐immune system interactions, combinations of biomarkers will be required for predicting individual patient responses to treatment and for monitoring combination strategies to overcome treatment resistance. To this end, the “immunogram” has been proposed as a comprehensive framework to capture all relevant immunological variables. Here, we developed a method to convert transcriptomic data into immunogram scores (IGS). This immunogram includes 10 molecular...
Tue Aug 18, 2020 22:34
Abstract Hepatocellular carcinoma (HCC) is one of the common malignancies worldwide. Accumulating evidence reported the internal connection of epithelial‐mesenchymal transition (EMT) and cancer stem cells (CSCs), as well as their significance in metastasis and post‐operative recurrence. In this study, we determined an interesting ubiquitin‐proteasome pathway associated pseudogene of AOC4, also known as UPAT, was downregulated in 39.78% (37/93) of patients with hepatitis B virus (HBV) ‐ related HCC,...
Tue Aug 18, 2020 22:29
Abstract Radiation resistance is a major cause of esophageal cancer relapse or metastasis. Transcriptional co‐activator with PDZ binding domain (TAZ) is a final effector of the Hippo signaling pathway and plays critical roles in several types of cancer, but how it participates in the progression and radiation resistance of esophageal cancer remains unclear. Here, we revealed that TAZ was the strongest prognostic factor among Hippo‐pathway members. TAZ overexpression predicted poor outcome and adverse...
Tue Aug 18, 2020 11:20
Inotuzumab ozogamicin (InO), an anti‐CD22 monoclonal antibody conjugated to calicheamicin, is approved in Europe and the United States for treatment of adults with relapsed or refractory acute lymphoblastic leukemia (ALL). Population analyses were performed to evaluate the relationship between InO exposure and efficacy and safety end points in patients with ALL. The probability of achieving complete remission/complete remission with incomplete hematologic recovery (CR/CRi) and minimal residual disease...
Tue Aug 18, 2020 21:36
The FDA Oncology Center of Excellence (OCE) commenced the Real-Time Oncology Review (RTOR) pilot project in February 2018 to facilitate earlier submission of topline results and datasets to support an earlier start to the FDA application review. RTOR was initially begun to support supplemental drug applications to add new indications, dosing regimens, or other clinical information to the prescribing information, but was later expanded to include original new drug applications and biological license...
Wed Aug 19, 2020 15:47
Publication date: October 2020Source: Critical Reviews in Oncology/Hematology, Volume 154Author(s): Christian Rolfo, Andrés F. Cardona, Massimo Cristofanilli, Luis Paz-Ares, Juan Jose Diaz Mochon, Ignacio Duran, Luis E. Raez, Alessandro Russo, Jose A. Lorente, Umberto Malapelle, Ignacio Gil-Bazo, Eloisa Jantus-Lewintre, Patrick Pauwels, Tony Mok, María José Serrano, on behalf of the ISLB
Wed Aug 19, 2020 17:29
Publication date: Available online 18 August 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): F. Savioli, J. Edwards, D. McMillan, S. Stallard, J. Doughty, L. Romics
Wed Aug 19, 2020 17:29
Publication date: September 2020Source: European Journal of Cancer, Volume 137Author(s): Diane Letourneur, François-Xavier Danlos, Aurélien Marabelle
Wed Aug 19, 2020 19:44
Publication date: Available online 19 August 2020Source: European Journal of Surgical OncologyAuthor(s): Xishan Hao
Wed Aug 19, 2020 17:59
Publication date: Available online 19 August 2020Source: European Journal of Surgical OncologyAuthor(s): Masakuni Noguchi, Masafumi Inokuchi, Miki Noguchi, Emi Morioka, Tomoko Kurita
Wed Aug 19, 2020 17:59
Publication date: Available online 19 August 2020Source: European Journal of Surgical OncologyAuthor(s): Katrina Knight, Muhammed Al-Wahid, Jia Xun Choong, Kevin Burton, Rhona Lindsay, Ruth F. McKee, John H. Anderson, Campbell SD. Roxburgh
Wed Aug 19, 2020 17:59
Publication date: Available online 19 August 2020Source: European Journal of Surgical OncologyAuthor(s): Kyohei Yugawa, Tomoharu Yoshizumi, Yohei Mano, Shinji Itoh, Noboru Harada, Toru Ikegami, Kenichi Kohashi, Yoshinao Oda, Masaki Mori
Wed Aug 19, 2020 17:59
Publication date: Available online 18 August 2020Source: European Journal of Surgical OncologyAuthor(s): Masahiro Watanabe, Takahiro Kinoshita, Shinji Morita, Masahiro Yura, Masanori Tokunaga, Sho Otsuki, Yukinori Yamagata, Akio Kaito, Takaki Yoshikawa, Hitoshi Katai
Wed Aug 19, 2020 17:59
Future Oncology, Ahead of Print.
Wed Aug 19, 2020 13:27
Future Oncology, Ahead of Print.
Wed Aug 19, 2020 08:45
Future Oncology, Ahead of Print.
Wed Aug 19, 2020 13:09
An amendment to this paper has been published and can be accessed via the original article.
Wed Aug 19, 2020 03:00
Abstract AKT‐mTORC1 (mammalian target of rapamycin complex 1) signaling pathway plays a critical role in tumorigenesis and can be targeted by rapamycin. However, the underlying mechanism of how long noncoding RNA (lncRNAs) regulate the AKT‐mTORC1 pathway remains unclear. EPIC1 (epigenetically‐induced lncRNA 1) is a Myc‐binding lncRNA, which has been previously demonstrated to be overexpressed in multiple cancer types. In a pathway analysis including 4962 cancer patients, we observed that lncRNA...
Tue Aug 18, 2020 20:20
Abstract Long noncoding RNAs (lncRNAs) can act as oncogene and tumor suppressor genes in many types of cancers including breast cancer (BC). Our previous study has indicated microRNA (miR)‐125a‐5p was downregulated and function as a tumor suppressor in BC. However, its upstream regulation mechanism is still unclear. In this study, we used bioinformatics algorithms, RNA pulldown assay, and dual‐luciferase reports assay to predict and confirm lncRNA CERS6‐AS1 interacted with miR‐125a‐5p. Then we found...
Tue Aug 18, 2020 12:27
Abstract Introduction Glioblastoma (GBM) has a survival rate of around 2 years with aggressive current standard of care. While other tumors have responded favorably to trials combining immunotherapy and chemotherapy, GBM remains uniformly deadly with minimal increases in overall survival. GBM differ from others due to being isolated behind the blood brain barrier, increased heterogeneity and mutational burden, and immunosuppression...
Wed Aug 19, 2020 03:00
Abstract Purpose There is large variability in reported incidence rates of primary brain/CNS tumors across the world, with mostly higher rates in higher-income countries. The aim was to compare malignant and benign brain/CNS tumor incidence between Zurich (Switzerland), a high-income country, and Georgia, a lower middle-income country. Methods For...
Wed Aug 19, 2020 03:00
Abstract Objective Psychosocial distress among cancer patients leads to poor health outcomes and lower satisfaction. However, little is known about psychosocial distress among disadvantaged populations. We examined the prevalence, predictors, and follow‐up experience of psychosocial distress among cancer patients within a diverse, urban, and multi‐lingual safety‐net setting. Methods We conducted a retrospective cohort study of cancer patients undergoing psychosocial distress screening at...
Tue Aug 18, 2020 18:20
Abstract Objective Various psychosocial support services for cancer patients are available in Japan; however, their utilization rate is low. The present study aimed to examine factors contributing to help‐seeking behavior in the use of psychosocial support services among cancer outpatients at three stages: Precontemplation (without adjustment disorder or major depression), Precontemplation (with adjustment disorder or major depression), and Contemplation. Methods We conducted a web‐based...
Tue Aug 18, 2020 18:19
Accurate, non-invasive delineation of areas of highest suspicion for biologically significant prostate cancer (PCa) is necessary for proper risk stratification and further treatment planning. Focal therapies and focal radiation boosting techniques are becoming an attractive option due to their improved morbidity profiles, while guided biopsy is showing promise towards improved sensitivity of lesion identification as opposed to systematic trans-rectal ultrasound guided biopsy [1,2]. Limitations in...
Wed Aug 19, 2020 03:00
Telomeres safeguard the genome by suppressing illicit DNA damage responses at chromosome termini. In order to compensate for incomplete DNA replication at telomeres, most continually dividing cells, including many cancers, express the telomerase ribonucleoprotein (RNP) complex. Telomerase maintains telomere length by catalyzing de novo synthesis of short DNA repeats using an internal telomerase RNA (TR) template. TRs from diverse species harbor structurally conserved domains that contribute to RNP...
Wed Aug 19, 2020 15:03
Publication date: October 2020Source: Cancer Epidemiology, Volume 68Author(s): J. Smith Torres-Roman, Virgilio Gomez-Rubio, Lara Sanchez-Trujillo, Eva Delgado-Rosas, Francisco Puche-Vergara, Jose Miguel Sanz-Anquela, Miguel Angel Ortega
Wed Aug 19, 2020 15:10
Publication date: Available online 18 August 2020Source: Seminars in OncologyAuthor(s): Marie-Daphné t'Kint de Roodenbeke, Noam Pondé, Laurence Buisseret, Martine Piccart
Wed Aug 19, 2020 20:33
Publication date: Available online 18 August 2020Source: Seminars in OncologyAuthor(s): Philip Bredin, Janice Walshe, Neelima Denduluri
Wed Aug 19, 2020 20:33
Abstract Purpose To assess acute cardiac toxicity caused by intraoperative radiotherapy (IORT) with low-energy x‑rays for early breast cancer. Methods We prospectively analyzed pre- and postoperative troponin I and NT-proBNP in 94 women who underwent breast-conserving surgery between 2013 and 2017 at the Department of Gynecology and Obstetrics of the...
Wed Aug 19, 2020 03:00
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