Abstract Background Atopy, the overall tendency to become sensitized to an allergen, is heritable but seldom ascribed to mutations within specific genes. Atopic individuals develop abnormally elevated IgE responses to immunization with potential allergens. To gain insight into the genetic causes of atopy, we carried out a forward genetic screen for atopy in mice. Methods We screened mice carrying homozygous and heterozygous N‐ethyl‐N‐nitrosourea (ENU)‐induced germline mutations for aberrant...
Tue Aug 18, 2020 19:51
Publication date: Available online 19 August 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Mengdi Lu, Augusto A. Litonjua, George T. O’Connor, Robert S. Zeiger, Leonard Bacharier, Michael Schatz, Vincent J. Carey, Scott T. Weiss, Hooman Mirzakhani
Wed Aug 19, 2020 12:39
Publication date: Available online 19 August 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Wei Wu
Wed Aug 19, 2020 12:39
ABSTRACT Background Fungal involvement in asthma is associated with severe disease. The full spectrum of fungal species in asthma is not well described and is derived largely from insensitive culture techniques. Objectives To use high‐throughput sequencing to describe the airway mycobiota in asthmatics with and without fungal‐sensitisation and healthy controls; to compare samples representing different airway compartments; to determine if the mycobiota was influenced by the fungal composition...
Tue Aug 18, 2020 22:00
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