Cyclin D1 in pediatric neuroblastic tumors
: A microarray analysis via Acta Histochemica Publication date: Available online 25 October 2015 *Source:*Acta Histochemica Author(s): Paolo Fagone, Ferdinando Nicoletti, Giada Maria Vecchio, Rosalba Parenti, Gaetano Magro Neuroblastoma is the most common extracranial solid childhood tumor, which is believed to originate from primitive neuroblasts giving rise to the sympathetic nervous system. It was previously shown that cyclin D1 (CCDN1) in pediatric neuroblastic tumors (neuroblastoma, ganglioneuroblastoma, and ganglioneuroma) recapitulates its expression during the development of p... περισσότερα »
Effects of adiposity on postural control and cognition
Effects of adiposity on postural control and cognition via ScienceDirect Publication: Gait & Posture Publication date: Available online 24 October 2015 *Source:*Gait & Posture Author(s): Hao Meng, Daniel P. O’Connor, Beom-Chan Lee, Charles S. Layne, Stacey L. Gorniak In the U.S., it is estimated that over one-third of adults are obese (body mass index (BMI)>30kg/m2). Previous studies suggest that obesity may be associated with deficits in cognitive performance and postural control. Increased BMI may challenge cognitive and postural performance in a variety of populations; however, most... περισσότερα »
Plantar cooling does not affect standing balance
: A systematic review and meta-analysis via ScienceDirect Publication: Gait & Posture Publication date: Available online 24 October 2015 *Source:*Gait & Posture Author(s): Matthew C. Hoch, Daniel M. Russell The purpose of this systematic review with meta-analysis was to critically appraise and synthesize the literature to determine if cooling the plantar surface of the foot is an effective method of inducing postural control alterations in healthy individuals. Specific variables that were evaluated within the meta-analysis included 1) the duration of the plantar cooling intervention, 2...περισσότερα »
Clinical importance of median mandibular flexure in oral rehabilitation
: a review by K. Sivaraman, A. Chopra, S. B. Venkatesh via Journal of Oral Rehabilitation Summary The mandible has a property to flex inwards around the mandibular symphysis with change in shape and decrease in mandibular arch width during opening and protrusion of the mandible. The mandibular deformation may range from a few micrometres to more than 1 mm. The movement occurs because of the contraction of lateral pterygoid muscles that pulls mandibular condyles medially and causes a sagittal movement of the posterior segments. This movement of mandible can have a profound influence o... περισσότερα »
Unilateral hyperhidrosis and hypothermia – symptoms of an intrathoracic tumour
Unilateral hyperhidrosis and hypothermia – symptoms of an intrathoracic tumour by B. Dyring-Andersen, S. Kamp, A. Madelung, C. Zachariae via British Journal of Dermatology A 34-year old man presented at the Department of Dermato-allergology, Herlev and Gentofte Hospital with unilateral hyperhidrosis localized to the right axilla through approximately 10 years without progression of symptoms. The patient often experienced that his right hand was colder than the left, especially during bouts of hyperhidrosis. The symptoms usually arose in stressful situations. The patient had no sensor...περισσότερα »
Chemotherapy : Infections Associated With Tunnelled Indwelling Pleural Catheters
Infections Associated With Tunnelled Indwelling Pleural Catheters in Patients Undergoing Chemotherapy by Mekhaiel, Essam; Kashyap, Rahul; Mullon, John J.; Maldonado, Fabien via Journal of Bronchology & Interventional Pulmonology - Most Popular Articles Background: Malignant pleural effusions are common complications of advanced malignancies and are associated with significant morbidity and reduced survival. Tunnelled indwelling pleural catheters (TIPCs) are implantable devices used for palliation of symptomatic malignant pleural effusions. Although complication rates are overall low, ...περισσότερα »
MicroRNA-101 polymorphisms and risk of head and neck squamous cell carcinoma
in a Chinese population via Tumor Biology AbstractMicroRNAs (miRNAs) play important roles in regulation of gene expressions and likely have involvement in cancer susceptibility and disease progression. MicroRNA-101 (miR-101) has been well established as a tumor suppressor, and aberrant expression of miR-101 levels has been previously reported in different malignancies including head and neck squamous cell carcinoma (HNSCC). However, the role of single nucleotide polymorphisms (SNPs) of miR-101 in the susceptibility to HNSCC remains unclear. In this study, we genotyped 11 selected SN... περισσότερα »
miR-145 in stem cell characteristics of human laryngeal squamous cell carcinoma Hep-2 cells
The role of via Tumor Biology AbstractThe cancer stem-like cells (CSLCs) are tumorigenic cells promoting initiation, progression, and spread of the tumor. Accumulating evidences suggested the presence of CSLCs in distinct tumors including laryngeal squamous cell carcinoma (LSCC). MicroRNAs have been proposed as significant regulators of carcinogenesis, and several of them have been demonstrated to have direct roles in survival of CSLCs. In this study, we aimed to explore the role of miR-145, which is downregulated in LSCC, on cancer stem cell potency of laryngeal cancer cells. We in... περισσότερα »
The role of astrocytes in the progression of brain cancer
: complicating the picture of the tumor microenvironment via Tumor Biology AbstractGliomas and brain-metastatic tumors contribute to hundreds of thousands of deaths every year. Typical survival times for brain cancer patients, even with surgical, chemotherapy, and radiation treatment, remain very low despite advances in treatment. In brain cancers, astrocytes, which comprise approximately 50 % of the cells in the brain, become activated, resulting in a layer of reactive astrocytes surrounding the tumor. This process of reactive gliosis, which involves the secretion of growth factors ... περισσότερα »
Green tea polyphenol EGCG
suppresses osteosarcoma cell growth through upregulating miR-1 via Tumor Biology Abstract(−)-Epigallocatechin-3-gallate (EGCG), the most abundant and active polyphenol in green tea, has been demonstrated to have anticancer effects in a wide variety of human cancer. MicroRNAs (miRNAs) are a class of short noncoding RNAs and play important role in gene regulation and are critically involved in the pathogenesis and progression of human cancer. This study aims to investigate the effects of EGCG on osteosarcoma (OS) cells and elucidate the underlying mechanism. Cellular function assays r... περισσότερα »
miR-138 in the regulation of larynx carcinoma cell metastases
Role of via Tumor Biology AbstractThe cases of larynx carcinoma (LC) with poor prognosis largely result from the distal metastases of the primary tumor. Since microRNAs (miRNAs) play critical roles during cancer metastases, determination of the involved miRNAs in the regulation of the LC metastases may provide novel therapeutic targets for LC treatment. Here, we studied the LC specimens from the patients and found that the levels of miR-138 were significantly decreased and the levels of ZEB2, a critical factor that regulates cancer cell invasiveness, were significantly increased in ... περισσότερα »
Concurrent chemoradiotherapy versus radiotherapy alone in stage II nasopharyngeal carcinoma treated with IMRT
Long-term outcomes of concurrent chemoradiotherapy versus radiotherapy alone in stage II nasopharyngeal carcinoma treated with IMRT: a retrospective study via Tumor Biology AbstractThis study aimed to evaluate the efficacy of concurrent chemoradiotherapy (CCRT) for stage II nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT). A total of 249 patients were retrospectively reviewed. All patients were treated with IMRT. One hundred forty-three patients treated with CCRT and 106 patients treated with IMRT alone. With a median follow-up of 59.4... περισσότερα »
Recurrence of Skull Base Meningiomas
: The Role of Aggressive Removal in Surgical Treatment by da Silva, Carlos Eduardo via Journal of Neurological Surgery Part B: Skull Base J Neurol Surg B DOI: 10.1055/s-0035-1566251 Objectives The recurrence of meningiomas is a crucial aspect that must be considered during the planning of treatment strategy. The Simpson grade classification is the most relevant surgical aspect to predict the recurrence of meningiomas. We report on a series of patients with recurrent skull base meningiomas who were treated with the goal of radical removal. Design A retrospective study. Setting Hospital...περισσότερα »
Hearing screening of newborn infants with OAEs and automated ABR
Combined OAE and AABR Approach for Newborn Hearing Screening via Audiology Hearing screening of newborn infants with OAEs and automated ABR is not the end-all or final goal for any audiologist; it is the very beginning. We sometimes get hung up on different parts of this process, whether it is identification which includes the screening, the diagnosis, or the intervention. The ultimate goal is better outcomes for patients, and screening is the very first part of this. I do not minimize the role of screening; a good screening strategy sets you up for a more accurate diagnosis and also... περισσότερα »
Advanced Management of Enlarged Vestibular Aqueduct
Advanced Management of Complex Cases: Enlarged Vestibular Aqueduct via Audiology I wanted to begin with a brief anatomy refresher as we begin talking about measurements used to define EVA. Think about the ear canal, tympanic membrane, middle ear ossicles, and the bony labyrinth of the inner ear. In the inner ear, you have posterior and superior semicircular canals that join to form the common crus, or what is sometimes labeled as the common canal. This space also contains the vestibule, which houses the utricle and saccule of the membranous labyrinth, and then there is the cochlea. Th... περισσότερα »
Generalized urticarial reaction following denosumab administration : Monoclonal antibody desensitization
Monoclonal antibody desensitization in a patient with by D. Gutiérrez-Fernández via Allergy, Asthma & Clinical Immunology - Latest Articles Denosumab is a human monoclonal antibody indicated for the treatment of osteoporosis in postmenopausal women with a high risk of fractures. To our knowledge, no cases of desensitization to this drug have been described in the literature. We report the first case of generalized urticarial reaction and facial angioedema after therapy with denosumab. A subcutaneous desensitization protocol was successfully completed in this patient. Rapid desensiti...περισσότερα »
Tropomyosin, the major tropical oyster Crassostrea belcheri allergen
and effect of cooking on its allergenicity by Zailatul Yadzir via Allergy, Asthma & Clinical Immunology - Latest Articles Background: Many types of shellfish including oysters are sometime cooked before ingestion and it has been demonstrated that cooking may affect the allergenicity of food. Therefore, the aim of our present study is to identify major and minor allergens of tropical oyster (Crassostrea belcheri) and to investigate the effect of different cooking processing on the allergenicity of this oyster. Methods: Raw, boiled, fried and roasted extracts of oyster were prepared. ... περισσότερα »
Pre-surgical margin assessment of basal cell carcinoma by reflectance confocal microscopy
A new approach for by M. Venturini, G. Gualdi, A. Zanca, L. Lorenzi, G. Pellacani, P G. Calzavara-Pinton via British Journal of Dermatology Abstract Background Surgical excision represents the elective treatment for BCC. Several non invasive approaches have been proposed for in vivo determination of tumor margin, in order to achieve a radical removal. Objectives We proposed a new approach for lateral margin detection in BCCs through the combination of dermoscopy and Reflectance Confocal Microscopy (RCM). Methods Ten patients with lesions clinically suggestive of non-pigmented BCCs wit...περισσότερα »
LEO 43204 is a novel ingenol derivative in development for the treatment of actinic keratosis
A randomised, phase IIa exploratory trial to assess the safety and preliminary efficacy of LEO 43204 in patients with actinic keratosis by S. Sinnya, J.M. Tan, T.W. Prow, C. Primiero, E. McEniery, J. Selmer, M.L. Østerdal, H.P. Soyer via British Journal of Dermatology Abstract Background LEO 43204 is a novel ingenol derivative in development for the treatment of actinic keratosis. Objectives To compare safety and preliminary efficacy of three doses of LEO 43204 with ingenol mebutate in actinic keratoses (AKs). Methods Patients with at least three visible, discrete, non-keratotic AKs on ... περισσότερα »
Diagnosis of noise-induced hearing loss (NIHL) : Guidelines for quantification
Guidelines for quantification of noise-induced hearing loss in a medicolegal context by M.E. Lutman, R.R.A. Coles, J.T. Buffin via Clinical Otolaryngology Abstract Objectives Guidelines published in 2000 by the authors are widely used by medical and legal professionals in the UK for diagnosis of noise-induced hearing loss (NIHL) in a medicolegal context. However, they cannot be used for quantification of the noise-induced hearing loss, which is required in most cases. This requirement is addressed. Design A method is developed here to quantify NIHL, thereby overcoming this shortcoming...περισσότερα »
Geotropic and apogeotropic persistent direction-changing positional nystagmus
Conversion between Jung Eun Shin, 2015-10-26 08:56:39 AM Volume 135, Issue 12, December 2015, pages 1238-1244 10.3109/00016489.2015.1070965 Jung Eun Shin Abstract *Conclusion:* Clinical features in the course of conversion differed between patients with SSNHL and cupulopathy, which indicates that the pathophysiology of persistent geotropic or apogeotropic DCPN and the mechanism of the change in nystagmus direction may differ between the two groups. *Objective:* The aim of this study is to investigate clinical characteristics of 10 patients with persistent DCPN who exhibited a conversi... περισσότερα »
Cochlear blood flow (CBF),Cochlea fluid pH,Hydrostatic positive pressure,vasodilator,and vasoconstrictor
Effects of perilymphatic pressure, sodium nitroprusside, and bupivacaine on cochlear fluid pH of guinea pigsMasaaki Suzuki, 2015-10-26 08:56:39 AM Volume 135, Issue 12, December 2015, pages 1219-1224 10.3109/00016489.2015.1077392 Masaaki Suzuki Abstract *Conclusions:* Hydrostatic positive pressure and vasoconstrictor acidified the cochlear fluids, whereas the vasodilator made the fluids alkaline. CBF might play a role in regulating cochlea fluid pH. *Objectives:* Cochlea fluid pH is highly dependent on the HCO3−/CO2 buffer system. Cochlear blood flow (CBF) supplies O2 and removes CO2....περισσότερα »
The physical treatment for BPPV
A tangible head model showing semicircular canals for demonstrating the physical treatment for BPPVMichiro Fujisaka, 2015-10-26 08:56:39 AM Volume 135, Issue 12, December 2015, pages 1212-1218 10.3109/00016489.2015.1064546 Michiro Fujisaka Abstract *Conclusions:* It was shown that practicing with a tangible head model with semicircular canals is a useful educational tool for learning the physical treatment for BPPV. *Objectives:*To assess the efficacy of using a tangible head model with semicircular canals to teach the physical treatment for BPPV. *Methods:* This study compared the num... περισσότερα »
Betahistine 48 mg daily during 3 months is an effective and safe option for the treatment of peripheral vertigo
Use of betahistine in the treatment of peripheral vertigoRubén Ramos Alcocer, 2015-10-26 08:56:39 AM Volume 135, Issue 12, December 2015, pages 1205-1211 10.3109/00016489.2015.1072873 Rubén Ramos Alcocer Abstract *Conclusion:* Clinical studies and meta-analyses demonstrated that betahistine is effective and safe in the treatment of Ménière’s disease, BPPV (benign paroxysmal positional vertigo), vestibular neuronitis, and other types of peripheral vertigo. *Objectives:* The goal of this paper is to review the pharmacological profile of betahistine and the evidence for its effectiveness... περισσότερα »
Influence mechanism of low-dose ionizing radiation on Escherichia coli DH5α population
based on plasma theory and system dynamics simulation via ScienceDirect Publication: Journal of Environmental Radioactivity Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 1 Author(s): Yi Sun, Dawei Hu, Liang Li, Zheng Jing, Chuanfeng Wei, Lantao Zhang, Yuming Fu, Hong Liu It remains a mystery why the growth rate of bacteria is higher in low-dose ionizing radiation (LDIR) environment than that in normal environment. In this study, a hypothesis composed of environmental selection and competitive exclusion was firstly proposed from observe...περισσότερα »
Tumor stage, tumor site and HPV dependent correlation of perfusion CT parameters and [18F]-FDG uptake
in head and neck squamous cell carcinoma via ScienceDirect Publication: Radiotherapy and Oncology Publication date: October 2015 *Source:*Radiotherapy and Oncology, Volume 117, Issue 1 Author(s): Marta Nesteruk, Stephanie Lang, Patrick Veit-Haibach, Gabriela Studer, Sonja Stieb, Stefan Glatz, Hossein Hemmatazad, Kristian Ikenberg, Gerhard Huber, Martin Pruschy, Matthias Guckenberger, Stephan Klöck, Oliver Riesterer Background and purposeThis study investigated whether tumor perfusion, FDG uptake and their correlation depend on tumor stage, site and HPV in head and neck cancer.Material... περισσότερα »
Cranial irradiation for primary central nervous system and skull base tumors
Fertility in childhood cancer survivors following via ScienceDirect Publication: Radiotherapy and Oncology Publication date: Available online 20 October 2015 *Source:*Radiotherapy and Oncology Author(s): Tamara Z. Vern-Gross, Julie A. Bradley, Ronny L. Rotondo, Daniel J. Indelicato Recent advances in pediatric cancer treatment have improved disease control and survival outcomes for childhood cancers survivors, including those treated for primary central nervous system and skull base malignancies. Future research in this population will focus on identifying risk factors for infertility... περισσότερα »
The interfractional position variation of esophageal tumors is more pronounced in the cranial–caudal direction and in the proximal stomach
Marker-based quantification of interfractional tumor position variation and the use of markers for setup verification in radiation therapy for esophageal cancer via ScienceDirect Publication: Radiotherapy and Oncology *Source:*Radiotherapy and Oncology Author(s): Peng Jin, Astrid van der Horst, Rianne de Jong, Jeanin E. van Hooft, Martijn Kamphuis, Niek van Wieringen, Melanie Machiels, Arjan Bel, Maarten C.C.M. Hulshof, Tanja Alderliesten PurposeThe aim of this study was to quantify interfractional esophageal tumor position variation using markers and investigate the use of markers ... περισσότερα »
Effectiveness of an 18F-FDG-PET based strategy to optimize the diagnostic trajectory of suspected recurrent laryngeal carcinoma after radiotherapy
: The RELAPS multicenter randomized trial via ScienceDirect Publication: Radiotherapy and Oncology *Source:*Radiotherapy and Oncology Author(s): Remco de Bree, Lisa van der Putten, Harm van Tinteren, Jan Wedman, Wim J.G. Oyen, Luuk M. Janssen, Michiel W.M. van den Brekel, Emile F.I. Comans, Jan Pruim, Robert P. Takes, Monique G.G. Hobbelink, Renato Valdés Olmos, Bernard F.A.M. van der Laan, Maarten Boers, Otto S. Hoekstra, C. René Leemans PurposeThe purpose of this study is to evaluate the efficacy of 18F-FDG-PET as first-line diagnostic investigation, prior to performing a direct l... περισσότερα »
HNC : Validation of the total dysphagia risk score (TDRS)
in head and neck cancer patients in a conventional and a partially accelerated radiotherapy scheme via ScienceDirect Publication: Radiotherapy and Oncology *Source:*Radiotherapy and Oncology Author(s): Daan Nevens, Sarah Deschuymer, Johannes A. Langendijk, Jean-François Daisne, Fréderic Duprez, Wilfried De Neve, Sandra Nuyts Background and purposeA risk model, the total dysphagia risk score (TDRS), was developed to predict which patients are most at risk to develop grade ⩾2 dysphagia at 6months following radiotherapy (RT) for head and neck cancer. The purpose of this study was to val... περισσότερα »
Measuring radiotherapy setup errors at multiple neck levels in NPC
nasopharyngeal cancer (NPC): A case for differential PTV expansion via ScienceDirect Publication: Radiotherapy and Oncology Publication date: Available online 22 October 2015 *Source:*Radiotherapy and Oncology Author(s): Timothy Cheo, Yvonne Loh, Desiree Chen, Khai Mun Lee, Ivan Tham Background and purposeWe aim to quantify the magnitude of the systematic and random setup errors at three different anatomical levels of the neck in Nasopharyngeal Carcinoma (NPC) when clivus matching is used, and recommend appropriate PTV margins for each level.Material and methodsThirty-six patients under... περισσότερα »
Refusal of postoperative radiotherapy
and its association with survival in head and neck cancer via ScienceDirect Publication: Radiotherapy and Oncology Publication date: Available online 24 October 2015 *Source:*Radiotherapy and Oncology Author(s): Zachary G. Schwam, Zain Husain, Benjamin L. Judson Background and purposeAdministering postoperative radiotherapy (PORT) is associated with improved survival and slower disease progression in select head and neck cancer patients. Predictive factors for PORT refusal have not been described in this population.Materials and methodsRetrospective analysis of 6127 head and neck cance... περισσότερα »
Elevated CSF bilirubin among those with and without an intracranial vascular cause of SAH (avSAH)
Clinical and diagnostic findings in patients with elevated cerebrospinal bilirubin by McCarron, M. O., Lynch, M., McCarron, P., McCluskey, G., McKee, J., McVerry, F., O'Kane, M. J. via Postgraduate Medical Journal Online First IntroductionCerebrospinal fluid (CSF) spectroscopy can identify subarachnoid haemorrhage (SAH) when CT is negative in patients presenting with acute severe headache. The primary objective of this study was to evaluate the clinical use and usefulness of CSF spectrophotometry. Secondary objectives were to identify other causes of elevated CSF bilirubin, to analys... περισσότερα »
Cerebral venous thrombosis: comparing characteristics of infective and non-infective aetiologies
: a 12-year retrospective study by Korathanakhun, P., Petpichetchian, W., Sathirapanya, P., Geater, S. L. via Postgraduate Medical Journal Online First BackgroundMost cases of cerebral venous thrombosis (CVT) have non-infective causes. Infective CVT, though less common, often results in a catastrophic outcome. The distinctive clinical characteristics of infection-associated CVT (IACVT) and non-infection-associated CVT (NIACVT) would facilitate early detection and proper management. ObjectiveTo compare the characteristics of IACVT and NIACVT. MethodsAll patients with CVT admitted to Son... περισσότερα »
Aspergillus flavus, produces the toxic and carcinogenic, polyketide synthase (PKS)-derived family of secondary metabolites termed aflatoxins
Functional characterization of a veA-dependent polyketide synthase gene in Aspergillus flavus necessary for the synthesis of asparasone, a sclerotium-specific pigment by Cary, Jeffrey W via Ghent University Academic Bibliography The filamentous fungus, Aspergillus flavus, produces the toxic and carcinogenic, polyketide synthase (PKS)-derived family of secondary metabolites termed aflatoxins. While analysis of the A. flavus genome has identified many other PKSs capable of producing secondary metabolites, to date, only a few other metabolites have been identified. In the process of stu...περισσότερα »
Association of vitamin D receptor gene polymorphisms and vitamin D levels with asthma and atopy
in Cypriot adolescents: a case–control study updated on Sun Oct 25, 2015 16:37 by Anna Papadopoulou via Multidisciplinary Respiratory Medicine - Latest Articles Background: Polymorphisms in the vitamin D receptor (VDR) gene have been studied in immune-related disorders either as independent contributors or in combination with vitamin D concentration. Vitamin D and VDR have been independently linked to asthma susceptibility. We investigated whether VDR variants were associated independently or in relation to vitamin D levels with asthma in Cypriot adolescents. Methods: We studied 190 ... περισσότερα »
ICD-9-CM: 386.10 - Vertigo, Peripheral, Unspecified 386.11 - Benign Paroxysmal Positional Vertigo; Benign Paroxysmal Positional Nystagmus 386.19 - Vertigo, Peripheral, Other and Unspecified; Aural Vertigo; Otogenic Vertigo 386.2 - Vertigo of Central Origin; Central Positional Nystagmus; Malignant Positional Nystagmus 438.85 - Late effects of cerebrovascular disease; Vertigo 780.4 - Dizziness and Giddiness; Light-headedness; Vertigo NOS
Vertigo Medical Codes *ICD-9-CM:*386.10 -Vertigo, Peripheral, Unspecified386.11 -Benign Paroxysmal Positional Vertigo; Benign Paroxysmal Positional Nystagmus386.19 -Vertigo, Peripheral, Other and Unspecified; Aural Vertigo; Otogenic Vertigo386.2 -Vertigo of Central Origin; Central Positional Nystagmus; Malignant Positional Nystagmus438.85 -Late effects of cerebrovascular disease; Vertigo780.4 -Dizziness and Giddiness; Light-headedness; Vertigo NOS Overview Though sometimes inaccurately called "dizziness," vertigo occurs because of a disturbance in the system for balance in the body (v... περισσότερα »
Intravenous fluid to hydrate the patient and to correct hypoglycemia or electrolyte imbalance
Alcohol Intoxication DSM-5 303.00(F10.129), (F10.229), (F10.9292) Author: Heather Sheaffer, MA, LCSW ------------------------------ [image: Alcohol Intoxication DSM-5 303.00(F10.129), (F10.229), (F10.9292)] *DSM-5 Category Substance Related and Addictive Disorders*Introduction Alcohol intoxication is the direct result of alcohol consumption. The DSM-5 explains that alcohol intoxication is characterized by clinically significant behavioral or psychological changes that occur after drinking alcohol. Common symptoms include slurred speech, poor balance, dizziness, headache and nausea. Alco... περισσότερα »
Positional alcohol nystagmus (PAN) : Blood Alcohol Concentration (BAC), and becomes noticeable at around 400 mg/dL (.40% BAC).
Positional alcohol nystagmus From Wikipedia, the free encyclopedia *Positional alcohol nystagmus* (PAN) is nystagmus (visible jerkiness in eye movement) produced when the head is placed in a sideways position. PAN occurs when the specific gravity of the membrane space of the semicircular canals in the ear differs from the specific gravity of the fluid in the canals because of the presence of alcohol. - 1 PAN I - 2 PAN II - 3 Relationship Between PAN and the Effects of Intoxication - 4 PAN versus testing for HGN in intoxicated individuals - 5 See also - 6 References P... περισσότερα »
Dizziness
Dizziness is a general, non-specific term to indicate a sense of disorientation. Vertigo is a type of dizziness and refers to a false sensation that oneself or the surroundings are moving or spinning (usually accompanied by nausea and loss of balance) that is a result of a mismatch between vestibular, visual, and somatosensory systems.[1] Causes of vertigo are often differentiated into: - Central (cerebral cortex, cerebellum, brainstem) - eg, cerebrovascular disease, migraine, multiple sclerosis, acoustic neuroma, diplopia, alcohol intoxication. - Peripheral (vestibular... περισσότερα »
Vestibular neuritis (often called labyrinthitis) and ischemic stroke in the brainstem or cerebellum
Does my dizzy patient have a stroke? A systematic review of bedside diagnosis in acute vestibular syndrome • The most common causes of acute vestibular syndrome are vestibular neuritis (often called labyrinthitis) and ischemic stroke in the brainstem or cerebellum. • Vertebrobasilar ischemic stroke may closely mimic peripheral vestibular disorders, with obvious focal neurologic signs absent in more than half of people presenting with acute vestibular syndrome due to stroke. • Computed tomography has poor sensitivity in acute stroke, and diffusion-weighted magnetic resonance imaging... περισσότερα »
Is it a Stroke or Benign Dizziness?
A Simple Bedside Test Can Tell A bedside electronic device that measures eye movements can successfully determine whether the cause of severe, continuous, disabling dizziness is a stroke or something benign, according to results of a small study led by Johns Hopkins Medicine researchers. "Using this device can directly predict who has had a stroke and who has not," says David Newman-Toker, M.D., Ph.D., an associate professor of neurology and otolaryngology at the Johns Hopkins University School of Medicine and leader of the study described in the journal*Stroke*. "We’re spending hu...περισσότερα »
Dizziness due to TIA and Stroke
Dizziness due to TIA and Stroke Timothy C. Hain, MD Transient ischemic attacks or TIA's are brief episodes of neurological disturbance caused by reduced blood supply to an area of the brain. Strokes are longer lasting neurological disturbance, associated with permanent damage to the brain. This document discusses TIA's and strokes associated with dizziness, also known as *Vertebrobasilar TIA's and Strokes. *These strokes are from blockages of one or more of the arteries shown on the the picture to the right (Posterior Inferior Cerebellar Artery or PICA, vertebral arteries, anterio... περισσότερα »
