Arsenite suppresses angiogenesis of vascular endothelial cells

 mediated by Platelet Derived Growth Factor Receptor-beta

X Wang, Y Mou, Z Yue, H Zhang, X Su, Y Wang, R Li… - Environmental Toxicology …, 2016

Abstract The present study aimed to investigate the effects of sodium arsenite (NaAsO 2) on
the angiogenesis of human umbilical vein endothelial cells (HUVECs) and the mechanism
involved. Firstly, a Matrigel-based in vitro angiogenesis assay demonstrated that arsenite ...

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Vertigo with sudden hearing loss

: audio-vestibular characteristics

JM Pogson, RL Taylor, AS Young, LA McGarvie… - Journal of Neurology

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Rhinosinusitis

Bacteriology of the Middle Meatus in Chronic Rhinosinusitis with and without Polyposis

S Stern, T Hadar, Y Nachalon, H Ben-Zvi, E Soudry… - ORL, 2016

Abstract There are only limited data in the literature, and none specifically from the Middle
East, on the pathogenic bacteria in chronic rhinosinusitis (CRS) as opposed to healthy nasal
cavities and their association with disease severity. The present study was conducted in ...

Presentation to Emergency Departments for Acute Rhinosinusitis Disparities in Symptoms by Race and Insurance Status

RW Bergmark, AR Sedaghat - Otolaryngology--Head and Neck Surgery, 2016

Objective Medicaid and self-pay insurance statuses and race are associated with
emergency department (ED) presentation for uncomplicated acute rhinosinusitis (ARS). We
investigated whether ARS symptomatology could explain this disproportionate ED use.

[HTML] The Effect of Endoscopic Sinus Surgery in Chronic Rhinosinusitis Patients With Concurrent Asthma

A Taheri, E Vahedi, T Homaei - Thrita, 2016

Background: Chronic rhinosinusitis (CRS) and asthma are among the most important health-
related conditions with evident socio-economic effects. The relationship between asthma
and CRS has been considered in medical references for centuries. Previous studies have ...

Sleep Disruption in Chronic Rhinosinusitis

M Zitun - 2016

Abstract: Rationale: Sleep disruption is a widely known problem among chronic
rhinosinusitis (CRS) patients. Previous studies have shown an increased rate of obstructive
sleep apnea (OSA) in CRS patients. However, there is very little known about the risk ...

[HTML] Posttraumatic rhinosinusitis in patients with cranio-facial injuries

AA MIRZAJANOVICH, BS ABDUJALILOVICH… - European science review, 2016

Post-traumatic sinusitis develops due to combined craniofacial injuries and is accompanied
by brain damage, skull, orbit. Post-traumatic inflammation of the frontal sinus is in the first
place among post-traumatic lesions of the paranasal sinuses, while the rarest post- ...

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Arsenic in Drinking Water

Speciation of Arsenic in Drinking Water by Dispersive Liquid-Liquid Microextraction, Graphite Furnace Atomic Absorption Spectrometry, and Orthogonal Array Design

Y Zhang, L Fang, L Wang - Analytical Letters, 2016

Abstract Orthogonal array design was employed to optimize arsenic speciation in drinking
water in contact with materials by dispersive liquid-liquid microextraction followed by
graphite furnace atomic absorption spectrometry. Arsenic speciation was achieved by the ...

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Auditory Processing of Complex Sounds : COCHLEA SIMULATION

COCHLEA SIMULATION

APRMOF PERIPHERAL, A PROCESSING - Auditory Processing of Complex Sounds, 2016

The operation of the model is illustrated in Fig. 1 with the aid of a periodic sound consisting
of 31 equalramplitude harmonics of 125 Hz. Successive harmonics are phase shifted by an
ever decreasing amount to produce a'monotonic-phase'wave (Fig. la) in which some of ...

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Angiotensin II type 1 receptor dependent GLP-1 and PYY secretion in mice and humans

Endocrinology, Early Release.


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These new articles for The Journal of Clinical Endocrinology & Metabolism are available online

These new articles for The Journal of Clinical Endocrinology & Metabolism are available online

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These new articles for Endocrinology are available online

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Reduced equations for the hydroelastic waves in the cochlea

: The spring model

L Peres Hari, J Rubinstein, P Sternberg - Quarterly of Applied Mathematics, 2016

Abstract: Hydroelastic waves in the cochlea are studied through modeling a passive basilar
membrane as an elastic spring. A rigorous reduction of the three-dimensional equations for
the fluid pressure and deflection of the basilar membrane to a one-

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Carcinoma cells

[HTML] Cell Signaling: Proteins, Pathways and Mechanisms: Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced …

BH Sørensen, D Nielsen, UA Thorsteinsdottir… - American Journal of …, 2016

Abstract The leucine-rich repeat containing 8A (LRRC8A) protein is an essential component
of the volume-sensitive organic anion channel (VSOAC), and using pharmacological anion
channel inhibitors (NS3728, DIDS) and LRRC8A siRNA we have investigated its role in ...

Transplant drugs affect the expression of phase II and antioxidant enzymes in humancarcinoma cells HepG2 but not in primary cultures of human hepatocytes: In vitro …

R Vrzal, P Illes, Z Dvorak - Pharmacological Reports, 2016

Background We carried out a test whether or not transplant drugs such as cyclosporine A,
Rapamycin (Sirolimus), Tacrolimus, Everolimus and Mycophenolate mofetil affects the
expression of phase II enzymes comprising of UDP-glucuronosyltransferases (UGTs) and ...

[HTML] Proteasome Inhibition Contributed to the Cytotoxicity of Arenobufagin after Its Binding with Na, K-ATPase in Human Cervical Carcinoma HeLa Cells

Q Yue, H Zhen, M Huang, X Zheng, L Feng, B Jiang… - PloS one, 2016

Although the possibility of developing cardiac steroids/cardiac glycosides as novel cancer
therapeutic agents has been recognized, the mechanism of their anticancer activity is still not
clear enough. Toad venom extract containing bufadienolides, which belong to cardiac steroids ...

Growth arrest of lung carcinoma cells (A549) by polyacrylate-anchored peroxovanadate by activating Rac1-NADPH oxidase signalling axis

N Chatterjee, T Anwar, NS Islam, T Ramasarma… - Molecular and Cellular …

Abstract Hydrogen peroxide is often required in sublethal, millimolar concentrations to show
its oxidant effects on cells in culture as it is easily destroyed by cellular catalase. Previously,
we had shown that diperoxovanadate, a physiologically stable peroxovanadium ...

Autocrine MCP-1/CCR2 signaling stimulates proliferation and migration of renalcarcinoma cells

C Küper, FX Beck, W Neuhofer - Oncology Letters

Abstract. The chemokine monocyte chemoattractant protein‑1 [MCP‑1; also known as
chemokine (C‑C motif) ligand 2] is an important mediator of monocyte recruitment during
inflammatory processes. Pathologically high expression levels of MCP‑1 by tumor cells ...

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Laser

Laser fluorescence detection of subgingival calculus using the DIAGNOdent Classic versus periodontal probing

F Shakibaie, LJ Walsh - Lasers in Medical Science, 2016

... In the pres- ent study, to provide a more realistic challenge for calculus detection which
approximates the clinical environment ... Lasers Med Sci 29:519–524 18. Lussi A, Megert B,
Longbottom C, Reich E, Francescut P (2001) Clinical performance of a laser fluorescence device ...

Dermatologic surgery emergencies: Complications caused by systemic reactions, high-energy systems, and trauma

K Minkis, A Whittington, M Alam - Journal of the American Academy of Dermatology, 2016

... Northwestern University, Chicago, Illinois; c Department of Otolaryngology, Feinberg School ...
anaphylaxis; arrhythmia; complication; dermatologic emergency; fire; hematoma; laser injury;
lidocaine toxicity ... emergency that can result from dermatologic surgery, lasers, and cosmetic ...

Telephonic voice intelligibility after laryngeal cancer treatment: is therapeutic approach significant?

E Crosetti, M Fantini, G Arrigoni, L Salonia… - European Archives of Oto- …, 2016

... medical doctors (two of them were ENT residents and one was an ENT specialist) and ... [39] studied
VRQOL in T1 glottic cancer comparing irradiation and laser endoscopic excision ... ORL J
Otorhinolaryngol Relat Spec 68:253–258 6. Laccourreye H, Laccourreye O, Weinstein G ...

[PDF] MISTAKES IN THE DIAGNOSIS AND TREATMENT OF PRIMARY ANGLE-CLOSURE GLAUCOMA: CASE REPORT

V Maric, V Markovic, M Bozic, I Marjanovic - SANAMED, 2016

... ics, acyclovir, anti-glaucoma medications (timolol, dorzolamide, brimonidine and latanoprost)
and oral acetazolamide. ... If PAS are pres- ent, PAC is diagnosed. ... Laser iridotomy is a defin-
itive treatment to relieve pupillary block in PAC and PACG (19, 20). ...

[PDF] When alarm bells ring: emergency tinnitus

G Altissimi, M Salviati, R Turchetta, MP Orlando… - Eur Rev Med Pharmacol Sci, 2016

... Associ- azione Otorinolaringologi Ospedalieri Italiani (AOOI) [Italian Association of Hospital ENT],
even though ... G. Altissimi, M. Salviati, R. Turchetta, MP Orlando, A. Greco, M. De Vincentiis ...Laser
CO2 treatment can be an interesting alternative to conventional surgery, al- lowing ...

How effective is the Invisalign® system in expansion movement with Ex30′ aligners?

B Solano-Mendoza, B Sonnemberg, E Solano-Reina… - Clinical Oral Investigations, 2016

... Clin Oral Invest ... not possible to make absolute comparisons between the pres- ent research and
previous studies due to notable differences in the sample sizes examined and in the aims of these
studies [2–4]. The aims of this study were to determine whether it was possible to ...

[PDF] Will Customize Appliances Replace Standard Orthodontic Treatment?

KH Breuning - Iranian Journal of Orthodontics, 2016

... the world shows, that these digital dental models could replace plaster casts (3). Laser scanners
or ... and discussed with the patient; 6, communi- cation with the dentist and the oral surgeon in ...for
age at start of treatment and initial PAR, were not significantly differ- ent between the ...

[HTML] Treatment of Acne Keloidalis Nuchae: A Systematic Review of the Literature

EL Maranda, BJ Simmons, AH Nguyen, VM Lim… - Dermatology and Therapy

... Keywords: Acne keloidalis nuchae; Hair disorders; Lasers; Systematic review; Therapy; Treatment
INTRODUCTION ... Recent advances in light and laser therapies offer an alternative treatment option
for AKN. ... (top./ oral) Little improvem ent during active football season. Resolved ...

Dermatologic surgery emergencies: Complications caused by occlusion and blood pressure

K Minkis, A Whittington, M Alam - Journal of the American Academy of Dermatology, 2016

... School of Medicine, Northwestern University, Chicago, Illinois; c Department of Otolaryngology,
Feinberg School of ... the potential emergencies that can result from dermatologic surgery, lasers,
and cosmetic ... in the heart have also been seen after endovenous laser ablation, and ...

[PDF] POSTGRADUATE INSTITUTE OF MEDICINE

B CERTIFICATION - 2016

... If the trainee is successful at this 2 nd oral examination, the date of Board Certification should
be backdated as done routinely. ... Neuro Ophthalmology Review Manual – Bagandas 11.
Ophthalmic Lasers – Lesperance 12. Modern Ophthalmology 3 volumes 13. ...

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Neural correlates of older adults’ self-overestimation of stepping-over ability

Abstract

A growing body of literature indicates that cognitively intact older adults tend to overestimate their physical functioning (e.g., step-over ability), which may lead to fall risk. However, the neural correlates underlying this phenomenon are still unclear. We therefore investigated the neural basis of older adults' self-overestimation of stepping-over ability. A total of 108 well-functioning community dwelling older adults (mean age = 73.9 years) performed step-over tests (SOT) in two ways: self-estimation of step-over ability and an actual step-over task. During the self-estimation task, participants observed a horizontal bar at a distance of 7 m and estimated the maximum height (EH) of successful SOT trials. The actual SOT was then performed to determine the actual maximum height (AH) of successful trials. Participants also underwent positron emission tomography with ¹⁸F-fluorodeoxyglucose at rest to assess cerebral neural activity. The SOT showed that 22.2 % of participants overestimated their step-over ability. A regression analysis adjusted for potential covariates showed that increased self-estimation error (difference between EH and AH) was correlated with lower glucose metabolism in the bilateral orbitofrontal cortex (OFC) and left frontal pole. Only the significant correlation between self-estimation error and OFC activity persisted after correcting for multiple comparisons. For well-functioning healthy older adults, overlooking one's own functional decline may be influenced by reduced metabolic activity in the anterior prefrontal cortex, particularly in the OFC. Our findings also suggest that functional decline in the OFC prevents older adults from updating the qualitative/quantitative values of their impaired physical abilities.

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DTI metrics can be used as biomarkers to determine the therapeutic effect of stem cells in acute peripheral nerve injury

Purpose

To determine the role of diffusion tensor imaging (DTI) metrics as biomarkers for the therapeutic effects of mesenchymal stem cells (MSCs) in acute peripheral nerve injury.

Materials and Methods

Forty-four adult rats received subepineurial microinjection of MSCs (n = 22) or phosphate buffered saline (PBS, n = 22) 1 week after the sciatic nerve trunk crush injury. Sequential fat-suppressed T2-weighted imaging, T2 measurement, DTI and sciatic nerve functional assessment were performed at a 3.0 Tesla MR unit over an 8-week follow-up, with histological assessments performed at regular intervals. The sciatic nerve function index, T2 value, and DTI metrics, including fractional anisotropy (FA), axial diffusivity, radial diffusivity (RD), and mean diffusivity values of the distal stumps of crushed nerves were measured and compared between the two groups.

Results

Nerves treated with MSCs showed better functional recovery and exhibited more pronounced nerve regeneration compared with nerves treated with PBS. T2 values in nerves treated with MSCs or PBS showed a similar change pattern (P = 0.174), while FA and RD values in nerves treated with MSCs showed more rapid return (one week earlier) to baseline level than nerves treated with PBS (P = 0.045; 0.035). Nerves treated with MSCs had higher FA and lower RD values than nerves treated with PBS during the period from 2 to 3 weeks after surgery (P ≤ 0.0001, 0.004; P = 0.004, 0.006).

Conclusion

FA and RD values derived from DTI might be used as sensitive biomarkers for detecting the therapeutic effect of stem cells in acute peripheral nerve crush injuries. J. Magn. Reson. Imaging 2016.

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Stimulus rate and noise on speech-evoked auditory brainstem responses

[PDF] Effects of 

R Al Osman

Objective: to evaluate the effects of two auditory stressors, fast stimulus rate and/or addition of
white noise, on auditory processing of speech in normal hearing subjects. Design: Speech-evoked
auditory brainstem responses (ABR) were collected using a 300 ms formant-synthesized ...

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Columnar cells

Trilocular Palm Fruits from the Deccan Intertrappean Beds of India

SR Manchester, SD Bonde, DS Nipunage, R Srivatava… - International Journal of …, 2016

... strands. Endocarp stony, wall 0.8– 1.2 mm thick, composed mostly of polygonal cells
with an inner uniseriate locule lining of columnar cells. Septa 0.54 mm thick, composed
of about 15–20 layers of thick-walled polygonal cells. ...

Benign Müllerian Glandular Inclusions in Men Undergoing Pelvic Lymph Node Dissection

AJ Gallan, T Antic - Human Pathology, 2016

... None of the patients were receiving hormonal therapy. All 3 cases showed benign
glands with ciliated cuboidal to columnar cells and rare secretory cells,
morphologically comparable with endosalpingiosis in women. These ...

Morphophysiology and ultrastructure of the male reproductive accessory glands of the bats Carollia perspicillata, Glossophaga soricina and Phyllostomus discolor ( …

FF Martins, MR Beguelini, CCI Puga… - Acta Histochemica, 2016

The male reproductive accessory glands (RAGs) are important organs that contribute to the
secretion of different substances that composed the ejaculate. Despite.

Apocrine Hidrocystoma: A Rare Case Report

BP Belaldavar, V Suranagi, M Kalakuntla, B Raj… - Indian Journal of …, 2016

... examination. The eccrine hidrocys- toma cyst wall is usually composed of two layers
of cuboidal cells, whereas the apocrine type usually has a lining layer of high columnar
cells beneath which are elongated myoepithelial cells. ...

[HTML] A Case of Kartagener Syndrome With Pulmonary Hypertension

B Ghewade, S Cladius, S Chaudhari, A Bhake - Journal of Medical Cases, 2016

... Nasal scrape cytology for demonstration of cilia (Fig. 5) showed multiple groups of columnar
cells which were ciliated. Also seen are cell groups which were cuboidal along with few
inflammatory cells with degeneration and scanty hemorrhagic material and mucin. ...

Fabrication of antireflective polymer films with subwavelength structures using Roll to Roll Nanoimprint Lithography

CH Chuang, DM Lu, PH Wang, WY Lee - … Symposium on Design, Test, Integration and …, 2016

... in Fig. 4. The structure of the AAO can be described as a closely packed array of
columnar cells where each cell contains an elongated cylindrical nanopore that
is normal to the underlying aluminum surface. It was observed ...

A philosophy of rivers: Equilibrium states, channel evolution, teleomatic change and least action principle

GC Nanson, HQ Huang - Geomorphology, 2016

Until recently no universal agreement as to a philosophical or scientific methodological
framework has been proposed to guide the study of fluvial geomorphology.

[PDF] Endoscopic resection of a pedunculated Brunner's gland hamartoma of the duodenum

M Iwamuro

... The cystic structure present in the head of the polyp was lined with columnar cells without atypia,
indicating that the cysts consisted of dilated ducts of the Brunner's glands (Fig. 5E, F). ... lobules,
stromal cells, and marked cystic dilatation lined by columnar cells (Fig. 5A, B, ...

[PDF] Mandibular Ameloblastoma with Lung Metastasis 10 Years after Resection

JA Romualdez

... The cell block showed "stellate reticulum-like cells in clusters with peripheral palisadingcolumnar
cells, some exhibiting reverse polarization." (Figure 3) Final histopathology results were signed
out as "cytomorphologic findings consistent with metastatic ameloblastoma." Plain ...

Optimizing amniotic membrane tissue banking protocols for ophthalmic use

D Hettiarachchi, VHW Dissanayake… - Cell and Tissue Banking

... Morphology of human amniotic epithelial cells (hAECs). Freshly isolated hAECs at
passage 0 were observed to become adherent to the treated T25 culture flasks within
2 days of culture and appeared as flat, cuboidal to columnar cells. ...

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Neuroscience

[PDF] 2015: A New Impact Factor for ACS Chemical Neuroscience and New Topline Data for Global Pharmaceutical Products

CW Lindsley - 2016

The 2015 Thompson Reuters Journal Citation Reports was just released, and ACS Chemical
Neuroscience held its position. Our 2015 Impact Factor (IF) was 4.348, comparable in 2014
(IF = 4.362), while our 5 year IF increased to 4.51.1,2 In 2015, we reached a new high in ...

Psychosocial Resiliency is Associated with Lower Emotional Distress among Dyads of Patients and their Informal Caregivers in the Neuroscience Intensive Care Unit

KM Shaffer, E Riklin, JM Jacobs, J Rosand… - Journal of Critical Care, 2016

Purpose To examine the associations of patients' and their informal caregivers' psychosocial
resiliency factors with their own and their partners' emotion domains (distress, anxiety,
depression, anger) following admission to the Neuroscience Intensive Care Unit (Neuro- ...

Trajectories of research in translation studies: an update with a case study in theneuroscience of translation

M Tymoczko - Asia Pacific Translation and Intercultural Studies, 2016

Abstract The paper is a review of the major trajectories of research in translation studies
during the decade 2005–2015 and an updated projection of research trajectories for the
decade 2016–2025. It concludes with a brief case study illustrating the many possibilities ...

Understanding the role of sensory processing in occupation: An updated discourse with cognitive neuroscience

KL Williams - Journal of Occupational Science, 2016

ABSTRACT The association between sensory processing and occupation remains an
understudied concept in occupational science, although the sensory system plays an
integral role in connection and interaction between the individual and his or her ...

A primer on encoding models in sensory neuroscience

MAJ van Gerven - Journal of Mathematical Psychology, 2016

Abstract A principal goal in sensory neuroscience is to understand how properties of our
environment are reflected in neural activity patterns. Recent advances in computational
modeling provide increasingly accurate predictions of how neural populations across the ...

[HTML] Cognitive Neuroscience and Causal Inference: Implications for Psychiatry

N Dijkstra, L de Bruin - Frontiers in Psychiatry, 2016

In this paper we investigate to what extent it is justified to draw conclusions about causal
relations between brain states and mental states from cognitive neuroscience studies. We
first explain the views of two prominent proponents of the interventionist account of ...

[PDF] Changing Minds: Discussions in neuroscience, psychology and education

K Reid

Background Children think mathematically long before they start school. Before children
start learning mathematics at school, they show informal understanding of many numeracy
concepts (Song & Ginsburg, 1987; Sophian, Harley, & Manos Martin, 1995). This is ...

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A study of stress hyperglycemia and its relationship with the neurological outcome in patients presenting with acute ischemic stroke

2016-07-23T04-22-34Z
Source: International Journal of Advances in Medicine
Siva Ranganathan Green, Lokesh S., Tony Kadavanu Mathew, Jayasingh K., Ragupathy S..
Background: Cerebrovascular accident (CVA) continues to be the most common neurological disease in the developed and developing countries. It also stands as the 3rd more common cause of death after cardiovascular disease and cancer. Stroke related burden keeps rising among the patients, their relatives and treating consultants. The neurological outcome depends on various modifiable and non-modifiable risk factors. Among the modifiable risk factors, admission (stress) hyperglycemia has a deleterious effect on the neurological outcome. It is well known by various studies that diabetic patients have more severe outcome and neurological disability after acute stroke than the non-diabetic patients. Now stress hyperglycemia is also becoming a second serious marker to affect the neurological outcome of these stroke patients. The aim was to study the blood sugar level and it`s correlation with the neurological outcome among the acute ischemic stroke patients on admission and at third month of follow-up. Methods: It is a prospective and comparative study done in a tertiary care hospital. Adult patients (> 40 years) presenting with acute ischemic stroke were neurologically stratified based on National Institutes of Health Stroke Scale (NIHSS) and admission blood sugars were noted. They were subdivided into 3 groups. Group 1 consisting of 31 normoglycemic patients, group 2 consisting of 32 stress hyperglycemic patients and group 3 consisting of 40 Type 2 diabetes mellitus (T2DM) patients. They were again reassessed after 3 months with FBS, PPBS and neurological recovery by NHISS. Chi- square test / fischer exact test was used to compare between 3 groups. A p-value of


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Immunotherapy

Innovation in Bladder Cancer Immunotherapy.

HB Grossman, DL Lamm, AM Kamat, S Keefe… - Journal of Immunotherapy, 2016

Abstract Bladder cancer is understudied despite its high prevalence and its remarkable
response to immunotherapy. Indeed, funding for studies to explore mechanisms of tumor
immunity and novel new therapeutics is disproportionately lower for bladder cancer in ...

Immunotherapy in non-small cell lung cancer: the clinical impact of immune response and targeting

G Mountzios, H Linardou, P Kosmidis - Annals of Translational Medicine, 2016

Abstract Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related
death worldwide. In recent years, through a better understanding of the interactions between
the immune system and tumor cells (TC), immunotherapy has emerged as a promising ...

Prospecting TCRs for immunotherapy

Z Fehervari - Nature Immunology, 2016

The elimination of tumors through vaccination or the adoptive transfer of tumor-specific T
cells is an attractive option but is technically challenging because of difficulties in raising
robust and appropriate immune responses. In Science, Schumacher and colleagues study ...

[HTML] Cancer immunotherapy trials: leading a paradigm shift in drug development

LA Emens, LH Butterfield, FS Hodi, FM Marincola… - Journal for ImmunoTherapy …, 2016

Background Cancer immunotherapy has a long history in the clinic. William Coley was an
orthopedic surgeon in the late 1800's who noted marked tumor regression in a patient with
severe erysipelas. Based on this observation, he hypothesized that stimulating the ...

[HTML] Purity of transferred CD8+ T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1

HA Watson, G Dolton, J Ohme, K Ladell, M Vigar… - Immunology and Cell …, 2016

Abstract Adoptive transfer of tumor-specific cytotoxic T cells is a promising advance in
cancer therapy. Similarly, checkpoint inhibition has shown striking clinical results in some
patients. Here we combine adoptive cell transfer with ablation of the checkpoint protein ...

CIMT 2016: Mechanisms of efficacy in cancer immunotherapy-Report on the 14th Annual Meeting of the Association for Cancer Immunotherapy

LM Kranz, M Birtel, L Hilscher, C Grunwitz… - Human Vaccines & …, 2016

Cancer immunotherapy at its golden age is now included as a standard of care treatment for
cancer. Its well-established preclinical era has been flourishing in the recent decade with
many patients benefiting from the therapeutic efficacy of cancer immunotherapy through ...

Melanoma immunotherapy dominates the field

P Diamantopoulos, H Gogas - Annals of Translational Medicine, 2016

Abstract The incidence of melanoma is increasing worldwide and despite early detection
and intervention, the number of patients dying from metastatic disease continues to rise. The
prognosis of advanced melanoma remains poor, with median survival between 6 and 9 ...

Human γδ T cells: From a neglected lymphocyte population to cellularimmunotherapy: A personal reflection of 30years of γδ T cell research

D Kabelitz - Clinical Immunology, 2016

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Cellular immunotherapy for malignant gliomas

Y Lin, H Okada - Expert Opinion on Biological Therapy, 2016

Abstract Introduction: Cancer immunotherapy has made much progress in recent years.
Clinical trials evaluating a variety of immunotherapeutic approaches are underway in
patients with malignant gliomas. Thanks to recent advancements in cell engineering ...

[HTML] A short CD3/CD28 costimulation combined with IL-21 enhance the generation of human memory stem T cells for adoptive immunotherapy

C Alvarez-Fernández, L Escribà-Garcia, S Vidal… - Journal of Translational …, 2016

Background Immunotherapy based on the adoptive transfer of gene modified T cells is an
emerging approach for the induction of tumor-specific immune responses. Memory stem T
cells, due to their enhanced antitumor and self-renewal capacity, have become potential ...

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Squamous Cell Carcinoma

Aberrant Expression of the Tight Junction Molecules Claudin-1 and Zonula Occludens-1 Mediates Cell Growth and Invasion in Oral Squamous Cell Carcinoma

H Babkair, M Yamazaki, MS Uddin, S Maruyama, T Abé… - Human Pathology, 2016

We reported that altered cell contact mediated by E-cadherin is an initial event in the
pathogenesis of oral epithelial malignancies. To assess other effects of cell adhesion, we
examined the expression levels of tight junction (TJ) molecules in oral carcinoma in-situ ( ...

PICSAR: Long Noncoding RNA in Cutaneous Squamous Cell Carcinoma

Y Luo, SL Morgan, KC Wang - Journal of Investigative Dermatology, 2016

It is increasingly evident that long noncoding RNAs may play the roles of both oncogenes
and tumor suppressors during cancer development. A new study from Piipponen et al.
provides evidence that a long noncoding RNA, PICSAR, promotes cutaneous squamous ...

Cigarette use, comorbidities, and prognosis in a prospective head and necksquamous cell carcinoma population

LA Peterson, EL Bellile, GT Wolf, S Virani, AG Shuman… - Head & Neck, 2016

Background To better understand the associations between a history of tobacco use and
survival outcomes, cigarette use was prospectively surveyed in 687 previously untreated
patients with cancer of the oral cavity (n= 271), oropharynx (n= 257), larynx (n= 135), or ...

Targeting DDR2 in Head and Neck Squamous Cell Carcinoma with Dasatinib

A von Mässenhausen, C Sanders, J Brägelmann… - International Journal of …, 2016

Abstract Squamous cell carcinoma of the head and neck (HNSCC) is the tenth most
common tumor entity in men worldwide. Nevertheless therapeutic options are mostly limited
to surgery and radio-chemotherapy resulting in 5-year survival rates of around 50%. ...

[HTML] Low prevalence of HPV-driven head and neck squamous cell carcinoma in North-East Italy

L Baboci, D Holzinger, P Boscolo-Rizzo, G Tirelli… - Papillomavirus Research, 2016

Objectives To investigate the frequency of Human papillomavirus (HPV)-driven head and
neck squamous cell carcinoma (HNSCC) among patients living in North-East Italy, by
assessing HPV-DNA positivity in all tumors and additional markers whenever possible.

… of a Prognostic Tool for Prediction of Cancer-Specific Mortality after Complete Loco-Regional Pathological Staging for Squamous Cell Carcinoma of the Penis

SS Chang - The Journal of Urology, 2016

The authors examine and formulate a nomogram for patients with squamous cell carcinoma 
of the penis to predict cancer specific mortality based on clinical and histopathological
features. To this end, several modifications were made to the current T stage and N stage. ...

Local control of 151 head and neck cutaneous squamous cell carcinoma after radiotherapy: a retrospective study on efficacy and prognostic factors

JB Terra, MB Gaster, GB Halmos, JL Roodenburg… - Clinical Otolaryngology, 2016

Abstract Cutaneous squamous cell carcinoma (cSCC) is the second most common skin
cancer in the Caucasian population and its incidence is increasing worldwide. 1
Conventional surgical excision is recommended as the first choice of treatment for most ...

MicroRNA profiling of cisplatinresistant oral squamous cell carcinoma cell lines enriched withcancer-stem-cell-like and epithelial-mesenchymal transition-type features

R Dey Ghosh, S Ghuwalewala, P Das, S Mandloi… - Scientific Reports, 2016

Oral cancer is of major public health problem in India. Current investigation was aimed to
identify the specific deregulated miRNAs which are responsible for development of
resistance phenotype through regulating their resistance related target gene expression in ...

Erratum to: Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte colony-stimulating factor: a case report and …

N Kaneko, S Kawano, R Matsubara, Y Goto, T Jinno… - World Journal of Surgical …, 2016

After publication of the original article [1] it was brought to our attention that the funding
information was not correctly reflected in the article. The original Funding information
contains an incorrect number. The original sentence reads as: This work was supported ...

[HTML] Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma

HS Chahal, Y Lin, KJ Ransohoff, DA Hinds, W Wu… - Nature Communications, 2016

Cutaneous squamous cell carcinoma represents the second most common cutaneous
malignancy, affecting 7–11% of Caucasians in the United States. The genetic determinants
of susceptibility to cutaneous squamous cell carcinoma remain largely unknown. Here we ...

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Society of Anesthesia and Sleep Medicine Guidelines on Preoperative Screening and Assessment of Adult Patients With Obstructive Sleep Apnea

The purpose of the Society of Anesthesia and Sleep Medicine guideline on preoperative screening and assessment of adult patients with obstructive sleep apnea (OSA) is to present recommendations based on the available clinical evidence on the topic where possible. As very few well-performed randomized studies in this field of perioperative care are available, most of the recommendations were developed by experts in the field through consensus processes involving utilization of evidence grading to indicate the level of evidence upon which recommendations were based. This guideline may not be appropriate for all clinical situations and all patients. The decision whether to follow these recommendations must be made by a responsible physician on an individual basis. Protocols should be developed by individual institutions taking into account the patients' conditions, extent of interventions and available resources. This practice guideline is not intended to define standards of care or represent absolute requirements for patient care. The adherence to these guidelines cannot in any way guarantee successful outcomes and is rather meant to help individuals and institutions formulate plans to better deal with the challenges posed by perioperative patients with OSA. These recommendations reflect the current state of knowledge and its interpretation by a group of experts in the field at the time of publication. While these guidelines will be periodically updated, new information that becomes available between updates should be taken into account. Deviations in practice from guidelines may be justifiable and such deviations should not be interpreted as a basis for claims of negligence.

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Human otocariasis

[PDF] : Demographic and clinical outcomes of patients withear-canal ticks and a review of literature

T Cakabay, O Gokdogan, M Kocyigit - Journal of Otology, 2016

ABSTRACT Introduction: Otoacariasis is a rare infestation of the ear canal, which affects the
quality of life especially in rural areas. Different types of ticks and mites may cause
otoacariasis. Although treatment of otoacariasis is simple, diseases transmitted through ...

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Hearing

A Case of Hearing Loss after Bilateral Putaminal Hemorrhage: A Diffusion-tensor Imaging Study

T Koyama, K Domen - Progress in Rehabilitation Medicine, 2016

ABSTRACT Background: Magnetic resonance diffusion-tensor imaging (DTI) is a tool forthe
assessment of neural fiber integrity. We applied DTI in a patient with hearing lossthat
developed after bilateral putaminal hemorrhage. Case: A 59-year-oldwoman was referred ...

Pedestrian evacuation in view and hearing limited condition: The impact of communication and memory

S Xue, B Jia, R Jiang, J Shan - Physics Letters A, 2016

Abstract This paper studies pedestrian evacuation in view and hearing limited condition
based on the social force approach. It is assumed that there are two types of pedestrians:
Informed individuals know the exit location whereas uninformed individuals do not. The ...

An Appraisal of the Advancement of Emerging Technologies in Hearing Aids

MZ ur Rehman, SIA Shah, SO Gilani, M Jamil, F Amin - Indian Journal of Science and …, 2016

Background/Objectives: To shed light on the history of development of hearing aid, along
with the various pros and cons of each developed technological solution. Methods/Statistical
Analysis: A historical survey has been conducted, which highlights some of the more ...

Small-Group Phonological Awareness Training for Pre-Kindergarten Children withHearing Loss Who Wear Cochlear Implants and/or Hearing Aids

KL Werfel, M Douglas, L Ackal - Deafness & Education International, 2016

This case report details a year-long phonological awareness (PA) intervention for pre-
kindergarten children with hearing loss (CHL) who use listening and spoken language. All
children wore cochlear implants and/or hearing aids. Intervention occurred for 15 min/day, ...

[PDF] Analysis on the Value of Inner Music Hearing for Cultivation of Piano Learning

SU Shu - Cross-Cultural Communication, 2016

Abstract Piano performance, which is an auditory art, delivers fantastic melody into one's
brain through his ears. Then, the music appreciators can resonate emotionally and achieve
a mutual correspondence with their aesthetic ideas. Therefore, one not only needs to ...

[PDF] The prevalence of sensorineural hearing loss in patients with Kawasaki disease after treatment

K Toomaj, P Akbariasbagh, AK Yazdi, Y Aghighi… - Auditory and Vestibular …, 2016

Abstract Background and Aim: Kawasaki disease (KD) is an acute childhood febrile illness
with worldwide incidence and the highest incidence occurs in Asian children, with coronary
arteritis being the main complication. Sensorineural hearing loss (SNHL) has also been ...

Department of Speech-Language-Hearing University of Kansas, Lawrence, KS 66045

LL Feth, LJ Stover - Auditory Processing of Complex Sounds, 2016

Complex sounds exhibit fluctuations of amplitude and frequency. This paper reviews a
model of auditory processing of simultaneous amplitude and frequency modulations derived
from studies of Voelckerfs elementary modulated signals. A digital computer simulation of ...

[HTML] Advances in Molecular Genetics and the Molecular Biology of Deafness

S Nishio, I Schrauwen, H Moteki, H Azaiez - BioMed Research International, 2016

... Congenital sensorineural hearing loss is the most common sensory disorder, with
approximately 1 in every 1000 newborns in developed countries suffering from
severe-to-profound hearing loss. At least half of those cases are ...

An investigation of tinnitus using behavioural and functional imaging measures

J Davies - 2016

... is no universal cure. This thesis utilises data derived from an open-label,
non-randomised clinical trial whose original aim was to evaluate the effect of hearing
aids for hearing-impaired individuals with tinnitus. To achieve this ...

[HTML] Assessing auditory evoked potentials of wild harbor porpoises (Phocoena phocoena)

A Ruser, M Dähne, A van Neer, K Lucke… - The Journal of the …, 2016

Testing the hearing abilities of marine mammals under water is a challenging task. ... A method
to measure harbor porpoise hearing thresholds in situ in outdoor conditions using auditory
steady state responses of the brainstem was developed and tested. ...

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Phototherapies

Health economic analyses of psoriasis management: a systematic literature search

M Gutknecht, M Krensel, M Augustin - Archives of Dermatological Research, 2016

... UVB (USD5100) and PUVA (USD5700) had similar costs/ treatment success. Acitretin
monotherapy (USD17,300) was less costly compared to the biological therapies but
more costly than methotrexate or the phototherapies Hankin et al. ...

A systematic review on methods used to evaluate patient preferences in psoriasis treatments

M Gutknecht, ML Schaarschmidt, O Herrlein… - Journal of the European …, 2016

... Opmeer et al., 2007[48], Netherlands, Patients with moderate-to-severe plaque psoriasis
preferred oral therapies to phototherapies: a preference assessment based on clinical scenarios
with trade-off questions, 29, Trade-off questions, Treatment attributes. ...

Luminescent Ions in Advanced Composite Materials for Multifunctional Applications

G Bai, MK Tsang, J Hao - Advanced Functional Materials, 2016

Our site uses cookies to improve your experience. You can find out more about our
use of cookies in About Cookies, including instructions on how to turn off cookies
if you wish to do so. By continuing to browse this site you agree ...

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Screening based on incidence of severe retinopathy of prematurity in a tertiary care center in India: are Indian infants different?

2016-07-23T03-57-49Z
Source: International Journal of Contemporary Pediatrics
Umamaheswari Balakrishnan, Shafi Jan Mohammad Shaik, Nivetha Manian*, Muthayya Muthukumar, Mary Thomas, Prakash Amboiram, Binu Ninan, Ashok Chandrasekaran, Saravanan Ramaswamy.
Background: Incidence of retinopathy of prematurity (ROP) and screening criteria among the preterm infants varies widely. The incidence of ROP and severe ROP in different Birth Weight (BW) and Gestational Age (GA) groups were studied. The aim of the study was to review the existing screening criteria for ROP based on the highest birth weight and or gestational age of infants who developed severe ROP. Methods: This is a retrospective descriptive study of neonates with GA of ≤ 34 weeks and/or BW of ≤ 1750 gm screened for ROP by experienced ophthalmologist from January, 2011 to December, 2015. End point was either complete vascularisation or need for laser therapy as per ETROP guidelines. Severe ROP was defined as ROP needing treatment. Highest BW and or GA of infants who developed severe ROP were taken as cut off points for revising the existing screening criteria for ROP. Results: Among 1366 infants included in this study, 252 (18.4%) and 86 (6.2%) developed ROP and severe ROP, respectively. Mean GA was 29.2±1.4 weeks and 28.7±2.3 among infants with ROP and severe ROP, respectively. Stratified analysis showed a significant increase in the incidence of ROP with decreasing BW and GA (p


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